Page last updated: 2024-10-06

Cellular Senescence

Proteins (83)

ProteinSynonymsTaxonomy
NibrinCell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1Homo sapiens (human)
Polycomb complex protein BMI-1Polycomb group RING finger protein 4; RING finger protein 51Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 E1EC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme E1; 2.3.2.24; E2 ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Cyclin-dependent kinase 2EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinaseHomo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Transcription factor p65Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3Homo sapiens (human)
MAP kinase-activated protein kinase 5MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; EC 2.7.11.1; p38-regulated/activated protein kinase; PRAKHomo sapiens (human)
Fizzy-related protein homologFzr; CDC20-like protein 1; Cdh1/Hct1 homolog; hCDH1Homo sapiens (human)
Double-strand break repair protein MRE11EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog AHomo sapiens (human)
Protection of telomeres protein 1hPot1; POT1-like telomere end-binding proteinHomo sapiens (human)
Protein Mdm4Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
Signal transducer and activator of transcription 3Acute-phase response factorHomo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
Mitogen-activated protein kinase 7MAP kinase 7; MAPK 7; EC 2.7.11.24; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5Homo sapiens (human)
MAP kinase-activated protein kinase 3MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3; EC 2.7.11.1; Chromosome 3p kinase; 3pKHomo sapiens (human)
Histone-lysine N-methyltransferase EHMT2EC 2.1.1.-; Euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3; H3-K9-HMTase 3; Lysine N-methyltransferase 1C; Protein G9aHomo sapiens (human)
Mitogen-activated protein kinase kinase kinase 5EC 2.7.11.25; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5Homo sapiens (human)
Histone-lysine N-methyltransferase EHMT1EC 2.1.1.-; Euchromatic histone-lysine N-methyltransferase 1; Eu-HMTase1; G9a-like protein 1; GLP; GLP1; Histone H3-K9 methyltransferase 5; H3-K9-HMTase 5; Lysine N-methyltransferase 1DHomo sapiens (human)
Ubiquitin-conjugating enzyme E2 CEC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme C; 2.3.2.24; E2 ubiquitin-conjugating enzyme C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase CHomo sapiens (human)
Interferon betaIFN-beta; Fibroblast interferonHomo sapiens (human)
Telomeric repeat-binding factor 2TTAGGG repeat-binding factor 2; Telomeric DNA-binding proteinHomo sapiens (human)
Interleukin-8IL-8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating proteHomo sapiens (human)
Nuclear factor NF-kappa-B p105 subunitDNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Homo sapiens (human)
DNA-binding protein inhibitor ID-1Class B basic helix-loop-helix protein 24; bHLHb24; Inhibitor of DNA binding 1; Inhibitor of differentiation 1Homo sapiens (human)
Cyclin-dependent kinase inhibitor 2ACyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4AHomo sapiens (human)
Lysine-specific demethylase 6BEC 1.14.11.68; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6BHomo sapiens (human)
Polycomb protein EEDhEED; Embryonic ectoderm development protein; WD protein associating with integrin cytoplasmic tails 1; WAIT-1Homo sapiens (human)
Interleukin-6IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2Homo sapiens (human)
Retinoblastoma-associated protein p105-Rb; p110-RB1; pRb; Rb; pp110Homo sapiens (human)
ThioredoxinTrx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASPHomo sapiens (human)
Cyclin-dependent kinase inhibitor 1CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21Homo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 4MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKKHomo sapiens (human)
Histone H4Homo sapiens (human)
Histone-binding protein RBBP4Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48Homo sapiens (human)
Serine-protein kinase ATMEC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutatedHomo sapiens (human)
Histone-lysine N-methyltransferase EZH2EC 2.1.1.356; ENX-1; Enhancer of zeste homolog 2; Lysine N-methyltransferase 6Homo sapiens (human)
Histone-binding protein RBBP7Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7; Retinoblastoma-binding protein p46Homo sapiens (human)
Histone acetyltransferase KAT5EC 2.3.1.48; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting proteinHomo sapiens (human)
Transcription factor Sp1Homo sapiens (human)
CCAAT/enhancer-binding protein betaC/EBP beta; Liver activator protein; LAP; Liver-enriched inhibitory protein; LIP; Nuclear factor NF-IL6; Transcription factor 5; TCF-5Homo sapiens (human)
Proto-oncogene c-FosCellular oncogene fos; G0/G1 switch regulatory protein 7Homo sapiens (human)
Polycomb protein SUZ12Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homologHomo sapiens (human)
Histone chaperone ASF1AAnti-silencing function protein 1 homolog A; hAsf1; hAsf1a; CCG1-interacting factor A; CIA; hCIAHomo sapiens (human)
Telomeric repeat-binding factor 2-interacting protein 1TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog; RAP1 homolog; hRap1Homo sapiens (human)
Insulin-like growth factor-binding protein 7IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAFHomo sapiens (human)
Tumor suppressor ARFAlternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p14ARFHomo sapiens (human)
Anaphase-promoting complex subunit 4APC4; Cyclosome subunit 4Homo sapiens (human)
Cyclin-dependent kinase 4 inhibitor BMultiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4BHomo sapiens (human)
Ubiquitin-conjugating enzyme E2 D1EC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme D1; 2.3.2.24; E2 ubiquitin-conjugating enzyme D1; Stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugHomo sapiens (human)
Ubiquitin-conjugating enzyme E2 SEC 2.3.2.23; E2 ubiquitin-conjugating enzyme S; E2-EPF; Ubiquitin carrier protein S; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; Ubiquitin-protein ligase SHomo sapiens (human)
Anaphase-promoting complex subunit 2APC2; Cyclosome subunit 2Homo sapiens (human)
Anaphase-promoting complex subunit 1APC1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 proteinHomo sapiens (human)
Protein C-ets-2Homo sapiens (human)
Cell division cycle protein 27 homologAnaphase-promoting complex subunit 3; APC3; CDC27 homolog; CDC27Hs; H-NUCHomo sapiens (human)
DNA repair protein RAD50hRAD50; EC 3.6.-.-Homo sapiens (human)
E1A-binding protein p400EC 3.6.4.-; CAG repeat protein 32; Domino homolog; hDomino; Trinucleotide repeat-containing gene 12 protein; p400 kDa SWI2/SNF2-related proteinHomo sapiens (human)
Homeobox protein VENTXVENT homeobox homolog; VENT-like homeobox protein 2Homo sapiens (human)
Interleukin-1 alphaIL-1 alpha; Hematopoietin-1Homo sapiens (human)
Protein C-ets-1p54Homo sapiens (human)
High mobility group protein HMG-I/HMG-YHMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein RHomo sapiens (human)
Lamin-B1Homo sapiens (human)
ETS domain-containing transcription factor ERFEts2 repressor factor; PE-2Homo sapiens (human)
High mobility group protein HMGI-CHigh mobility group AT-hook protein 2Homo sapiens (human)
Protein HIRATUP1-like enhancer of split protein 1Homo sapiens (human)
Telomeric repeat-binding factor 1NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1Homo sapiens (human)
Anaphase-promoting complex subunit 15APC15Homo sapiens (human)
Cell division cycle protein 16 homologAnaphase-promoting complex subunit 6; APC6; CDC16 homolog; CDC16Hs; Cyclosome subunit 6Homo sapiens (human)
Histone H3.1tH3/t; H3t; H3/g; Histone H3.4Homo sapiens (human)
Anaphase-promoting complex subunit CDC26Anaphase-promoting complex subunit 12; APC12; Cell division cycle protein 26 homologHomo sapiens (human)
Adrenocortical dysplasia protein homologPOT1 and TIN2-interacting proteinHomo sapiens (human)
Anaphase-promoting complex subunit 16APC16; Cyclosome subunit 16Homo sapiens (human)
TERF1-interacting nuclear factor 2TRF1-interacting nuclear protein 2Homo sapiens (human)
Helicase MOV-10EC 3.6.4.13; Armitage homolog; Moloney leukemia virus 10 proteinHomo sapiens (human)
Ubinuclein-1HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear proteinHomo sapiens (human)
Anaphase-promoting complex subunit 11APC11; Cyclosome subunit 11; Hepatocellular carcinoma-associated RING finger proteinHomo sapiens (human)
Cell division cycle protein 23 homologAnaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8Homo sapiens (human)
Anaphase-promoting complex subunit 7APC7; Cyclosome subunit 7Homo sapiens (human)
Anaphase-promoting complex subunit 5APC5; Cyclosome subunit 5Homo sapiens (human)
Anaphase-promoting complex subunit 10APC10; Cyclosome subunit 10Homo sapiens (human)
Calcineurin-binding protein cabin-1Calcineurin inhibitor; CAINHomo sapiens (human)

Compounds (8)

CompoundDescription
Succinate
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
alpha-Ketoglutarate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.