Page last updated: 2024-10-06

Carbamazepine Metabolism Pathway

Proteins (7)

ProteinSynonymsTaxonomy
Cytochrome P450 3A4EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; CytochromeHomo sapiens (human)
Cytochrome P450 2C8EC 1.14.14.1; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylaseHomo sapiens (human)
Cytochrome P450 2B6EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1Homo sapiens (human)
Cytochrome P450 3A5EC 1.14.14.1; CYPIIIA5; Cytochrome P450-PCN3Homo sapiens (human)
Cytochrome P450 2C19EC 1.14.14.1; (R)-limonene 6-monooxygenase; 1.14.14.53; (S)-limonene 6-monooxygenase; 1.14.14.51; (S)-limonene 7-monooxygenase; 1.14.14.52; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Fenbendazole monooxygenase (4'-hydroxylating); 1.14.Homo sapiens (human)
Cytochrome P450 3A7EC 1.14.14.1; CYPIIIA7; Cytochrome P450-HFLA; P450HLp2Homo sapiens (human)
Epoxide hydrolase 1 EC 3.3.2.9; Epoxide hydratase; Microsomal epoxide hydrolase; mEHHomo sapiens (human)

Compounds (14)

CompoundDescription
hydronium ion
carbamazepineA dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
oxcarbazepineA carbamazepine derivative that acts as a voltage-gated sodium channel blocker. It is used for the treatment of PARTIAL SEIZURES with or without secondary generalization. It is also an inducer of CYTOCHROME P-450 CYP3A4.
NADH
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
10-hydroxycarbamazepine
10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide, (trans)-isomer
2-hydroxyiminostilbenestructure in first source
carbamazepine epoxidemetabolite of carbamazepine; RN given refers to unlabeled cpd
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
2-hydroxycarbamazepinemetabolite of carbamazepine found in blood and urine
2,3-dihydroxycarbamazepinestructure in first source
creolinfrom refined coal tar oils