Pathways > Carbamazepine Metabolism Pathway
Page last updated: 2024-10-06
Carbamazepine Metabolism Pathway
Proteins (7)
| Protein | Synonyms | Taxonomy |
|---|
| Cytochrome P450 3A4 | EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; Cytochrome | Homo sapiens (human) |
| Cytochrome P450 2C8 | EC 1.14.14.1; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase | Homo sapiens (human) |
| Cytochrome P450 2B6 | EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1 | Homo sapiens (human) |
| Cytochrome P450 3A5 | EC 1.14.14.1; CYPIIIA5; Cytochrome P450-PCN3 | Homo sapiens (human) |
| Cytochrome P450 2C19 | EC 1.14.14.1; (R)-limonene 6-monooxygenase; 1.14.14.53; (S)-limonene 6-monooxygenase; 1.14.14.51; (S)-limonene 7-monooxygenase; 1.14.14.52; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Fenbendazole monooxygenase (4'-hydroxylating); 1.14. | Homo sapiens (human) |
| Cytochrome P450 3A7 | EC 1.14.14.1; CYPIIIA7; Cytochrome P450-HFLA; P450HLp2 | Homo sapiens (human) |
| Epoxide hydrolase 1 | EC 3.3.2.9; Epoxide hydratase; Microsomal epoxide hydrolase; mEH | Homo sapiens (human) |
Compounds (14)
| Compound | Description |
|---|
| hydronium ion | |
| carbamazepine | A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties. |
| oxcarbazepine | A carbamazepine derivative that acts as a voltage-gated sodium channel blocker. It is used for the treatment of PARTIAL SEIZURES with or without secondary generalization. It is also an inducer of CYTOCHROME P-450 CYP3A4. |
| NADH | |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| 10-hydroxycarbamazepine | |
| 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide, (trans)-isomer | |
| 2-hydroxyiminostilbene | structure in first source |
| carbamazepine epoxide | metabolite of carbamazepine; RN given refers to unlabeled cpd |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| 2-hydroxycarbamazepine | metabolite of carbamazepine found in blood and urine |
| 2,3-dihydroxycarbamazepine | structure in first source |
| creolin | from refined coal tar oils |