Page last updated: 2024-10-06

CMP-N-acetylneuraminate biosynthesis I (eukaryotes)

Proteins (7)

ProteinSynonymsTaxonomy
N-acylneuraminate-9-phosphataseEC 3.1.3.29; Haloacid dehalogenase-like hydrolase domain-containing protein 4; Neu5Ac-9-PaseHomo sapiens (human)
N-acylneuraminate cytidylyltransferaseEC 2.7.7.43; CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthaseMus musculus (house mouse)
N-acylneuraminate cytidylyltransferaseEC 2.7.7.43; CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthaseRattus norvegicus (Norway rat)
N-acylneuraminate-9-phosphataseEC 3.1.3.29; Haloacid dehalogenase-like hydrolase domain-containing protein 4; Neu5Ac-9-PaseRattus norvegicus (Norway rat)
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseUDP-GlcNAc-2-epimerase/ManAc kinaseRattus norvegicus (Norway rat)
Sialic acid synthaseN-acetylneuraminate-9-phosphate synthase; 2.5.1.57; N-acetylneuraminic acid phosphate synthaseMus musculus (house mouse)
Sialic acid synthaseN-acetylneuraminate synthase; 2.5.1.56; N-acetylneuraminate-9-phosphate synthase; 2.5.1.57; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthaseHomo sapiens (human)

Compounds (27)

CompoundDescription
diphosphoric acid
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
MercuryA silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Uridine TriphosphateUridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
NickelA trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
thymidine 5'-triphosphateRN given refers to parent cpd
mercaptoethanolA water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
dithiothreitolA reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
ammonium sulfateSulfuric acid diammonium salt. It is used in CHEMICAL FRACTIONATION of proteins.
vanadatesOxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.
Cytidine MonophosphateCytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
Cytidine TriphosphateCytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.
Cytidine DiphosphateCytidine 5'-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate.
2-acetamido-2-deoxy-mannose-6-phosphatestructure in first source