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C20 prostanoid biosynthesis

Proteins (9)

ProteinSynonymsTaxonomy
Prostaglandin E synthaseEC 5.3.99.3; Glutathione peroxidase PTGES; 1.11.1.-; Glutathione transferase PTGES; 2.5.1.18; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 proteinHomo sapiens (human)
Prostaglandin G/H synthase 1EC 1.14.99.1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1Homo sapiens (human)
Prostaglandin G/H synthase 2EC 1.14.99.1; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2Homo sapiens (human)
Prostacyclin synthaseEC 5.3.99.4; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152; Prostaglandin I2 synthaseHomo sapiens (human)
Hematopoietic prostaglandin D synthaseH-PGDS; EC 5.3.99.2; GST class-sigma; Glutathione S-transferase; 2.5.1.18; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomeraseHomo sapiens (human)
Thromboxane-A synthase TXA synthase; TXS; EC 5.3.99.5; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152Homo sapiens (human)
Prostaglandin E synthase 2EC 5.3.99.3; Membrane-associated prostaglandin E synthase-2; mPGE synthase-2; Microsomal prostaglandin E synthase 2; mPGES-2; Prostaglandin-H(2) E-isomeraseHomo sapiens (human)
Prostaglandin E synthase 3EC 5.3.99.3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23Homo sapiens (human)
Prostaglandin-H2 D-isomeraseEC 5.3.99.2; Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; Lipocalin-type prostaglandin-D synthase; L-PGDS; Prostaglandin-D2 synthase; PGD2 synthase; PGDS; PGDS2Homo sapiens (human)

Compounds (7)

CompoundDescription
EpoprostenolA prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
DinoprostoneThe most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
DothiepinA tricyclic antidepressant with some tranquilizing action.
Thromboxane A2An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
Prostaglandin H2A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins.