Page last updated: 2024-10-06

Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine

Proteins (14)

ProteinSynonymsTaxonomy
Sepiapterin reductaseSPR; EC 1.1.1.153Homo sapiens (human)
Amine oxidase [flavin-containing] AEC 1.4.3.4; Monoamine oxidase type A; MAO-AHomo sapiens (human)
6-pyruvoyl tetrahydrobiopterin synthasePTP synthase; PTPS; EC 4.2.3.12Homo sapiens (human)
Dihydrofolate reductaseEC 1.5.1.3Homo sapiens (human)
Amine oxidase [flavin-containing] BEC 1.4.3.4; Monoamine oxidase type B; MAO-BHomo sapiens (human)
Tyrosine 3-monooxygenaseEC 1.14.16.2; Tyrosine 3-hydroxylase; THHomo sapiens (human)
Catechol O-methyltransferaseEC 2.1.1.6Homo sapiens (human)
Serotonin N-acetyltransferaseSerotonin acetylase; EC 2.3.1.87; Aralkylamine N-acetyltransferase; AA-NATHomo sapiens (human)
Phenylethanolamine N-methyltransferasePNMTase; EC 2.1.1.28; Noradrenaline N-methyltransferaseHomo sapiens (human)
Phenylalanine-4-hydroxylasePAH; EC 1.14.16.1; Phe-4-monooxygenaseHomo sapiens (human)
Dopamine beta-hydroxylaseEC 1.14.17.1; Dopamine beta-monooxygenaseHomo sapiens (human)
Dihydropteridine reductaseEC 1.5.1.34; HDHPR; Quinoid dihydropteridine reductase; Short chain dehydrogenase/reductase family 33C member 1Homo sapiens (human)
GTP cyclohydrolase 1EC 3.5.4.16; GTP cyclohydrolase I; GTP-CH-IHomo sapiens (human)
Acetylserotonin O-methyltransferaseEC 2.1.1.4; Hydroxyindole O-methyltransferase; HIOMTHomo sapiens (human)

Compounds (16)

CompoundDescription
EpinephrineThe active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
melatoninA biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
4a-carbinolamine tetrahydrobiopterinstructure given in first source
6-lactoyltetrahydropterinstructure given in first source
4a-hydroxytetrahydrobiopterinstructure given in first source
dyspropterinintermediate in biosynthetic pathway of tetrahydrobiopterin; structure given in first source
vanilmandelic acidA 3-O-methyl ether of 3,4-dihydroxymandelic acid. It is an end-stage metabolite of CATECHOLAMINES; EPINEPHRINE; and NOREPINEPHRINE.
hydroxyindoleacetic acid
SerotoninA biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
norepinephrine, (+,-)-isomer
phenylalanineAn essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
methoxyhydroxyphenylglycolSynthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover.
n-acetylserotonin
3-methoxytyrosine