Page last updated: 2024-10-06

Biomarkers for pyrimidine metabolism disorders

Proteins (14)

ProteinSynonymsTaxonomy
Thymidine kinase 2, mitochondrialEC 2.7.1.21; Mt-TKHomo sapiens (human)
Thymidylate synthaseTS; TSase; EC 2.1.1.45Homo sapiens (human)
Dihydropyrimidine dehydrogenase [NADP(+)]DHPDHase; DPD; EC 1.3.1.2; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenaseHomo sapiens (human)
Creatine kinase B-typeEC 2.7.3.2; Brain creatine kinase; B-CK; Creatine kinase B chain; Creatine phosphokinase B-type; CPK-BHomo sapiens (human)
Thymidine phosphorylaseTP; EC 2.4.2.4; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPaseHomo sapiens (human)
Ribonucleoside-diphosphate reductase large subunitEC 1.17.4.1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunitHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2EC 1.17.4.1; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunitHomo sapiens (human)
Beta-ureidopropionaseEC 3.5.1.6; BUP-1; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolaseHomo sapiens (human)
Dihydroorotate dehydrogenase (quinone), mitochondrialDHOdehase; EC 1.3.5.2; Dihydroorotate oxidaseHomo sapiens (human)
DihydropyrimidinaseDHP; DHPase; EC 3.5.2.2; Dihydropyrimidine amidohydrolase; HydantoinaseHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2 BEC 1.17.4.1; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2Homo sapiens (human)
5'(3')-deoxyribonucleotidase, cytosolic typeEC 3.1.3.-; Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1Homo sapiens (human)
tRNA pseudouridine synthase AEC 5.4.99.12; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase IHomo sapiens (human)
Cytosolic 5'-nucleotidase 3AEC 3.1.3.5; 7-methylguanosine phosphate-specific 5'-nucleotidase; 7-methylguanosine nucleotidase; 3.1.3.91; Cytosolic 5'-nucleotidase 3; Cytosolic 5'-nucleotidase III; cN-III; Pyrimidine 5'-nucleotidase 1; P5'N-1; P5N-1; PN-I; Uridine 5'-monophosphate hydHomo sapiens (human)

Compounds (24)

CompoundDescription
GlutathioneA tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
cysteineA thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
uridineA ribonucleoside in which RIBOSE is linked to URACIL.
Uridine TriphosphateUridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
phosphoribosyl pyrophosphateThe key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
thymineOne of four constituent bases of DNA.
uracilOne of four nucleotide bases in the nucleic acid RNA.
deoxyuridine2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.
Thymidine Monophosphate5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.
thymidineA nucleoside in which THYMINE is linked to DEOXYRIBOSE.
cytosineA pyrimidine base that is a fundamental unit of nucleic acids.
cytidineA pyrimidine nucleoside that is composed of the base CYTOSINE linked to the five-carbon sugar D-RIBOSE.
dihydrouracil
Cytidine MonophosphateCytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
Cytidine TriphosphateCytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.
Uridine Monophosphate5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
2'-deoxyuridylic acidRN given refers to parent cpd
Cytidine DiphosphateCytidine 5'-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate.
deoxyuridine triphosphate
orotidylic acidstructure
d-lactic acid
5-hydroxymethyluracilstructure
orotidineRN given refers to parent cpd; structure