Page last updated: 2024-10-06

BCR Signaling Pathway

Proteins (34)

ProteinSynonymsTaxonomy
RAF proto-oncogene serine/threonine-protein kinaseEC 2.7.11.1; Proto-oncogene c-RAF; cRaf; Raf-1Homo sapiens (human)
Protein kinase C beta typePKC-B; PKC-beta; EC 2.7.11.13Homo sapiens (human)
Tyrosine-protein kinase LynEC 2.7.10.2; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56LynHomo sapiens (human)
Protein kinase C alpha typePKC-A; PKC-alpha; EC 2.7.11.13Homo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Tyrosine-protein kinase SYKEC 2.7.10.2; Spleen tyrosine kinase; p72-SykHomo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 1MAP kinase kinase 1; MAPKK 1; MKK1; EC 2.7.12.2; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1Homo sapiens (human)
Tyrosine-protein kinase BTKEC 2.7.10.2; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinaseHomo sapiens (human)
Mitogen-activated protein kinase kinase kinase 1EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1Homo sapiens (human)
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformEC 3.1.3.16; CAM-PRP catalytic subunit; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoformHomo sapiens (human)
Nuclear factor of activated T-cells, cytoplasmic 1 NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATcHomo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
SHC-transforming protein 1SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1Homo sapiens (human)
Mitogen-activated protein kinase 8MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1Homo sapiens (human)
Growth factor receptor-bound protein 2Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2Homo sapiens (human)
Calmodulin-2Homo sapiens (human)
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoformEC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit beta isoform; CNA betaHomo sapiens (human)
Ras-related C3 botulinum toxin substrate 1EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1Homo sapiens (human)
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformEC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoformHomo sapiens (human)
Son of sevenless homolog 1SOS-1Homo sapiens (human)
Nuclear factor of activated T-cells, cytoplasmic 2 NF-ATc2; NFATc2; NFAT pre-existing subunit; NF-ATp; T-cell transcription factor NFAT1Homo sapiens (human)
GTPase HRasEC 3.6.5.2; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21rasHomo sapiens (human)
Calmodulin-1Homo sapiens (human)
Calcium release-activated calcium channel protein 1Protein orai-1; Transmembrane protein 142AHomo sapiens (human)
Proto-oncogene vavHomo sapiens (human)
Nuclear factor of activated T-cells, cytoplasmic 3NF-ATc3; NFATc3; NFATx; T-cell transcription factor NFAT4; NF-AT4; NF-AT4cHomo sapiens (human)
Nuclear factor of activated T-cells, cytoplasmic 4NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3Homo sapiens (human)
Proto-oncogene c-FosCellular oncogene fos; G0/G1 switch regulatory protein 7Homo sapiens (human)
ETS domain-containing protein Elk-1Homo sapiens (human)
Calmodulin-3Homo sapiens (human)
B-cell antigen receptor complex-associated protein alpha chainIg-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated proteinHomo sapiens (human)
B-cell antigen receptor complex-associated protein beta chainB-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 proteinHomo sapiens (human)
B-cell linker proteinB-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; SLP-65Homo sapiens (human)

Compounds (5)

CompoundDescription
Orthophosphate
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
inositol 1,4,5-trisphosphateIntracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
Phosphatidylinositol 4,5-DiphosphateA phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)