| Protein | Synonyms | Taxonomy |
|---|
| RAF proto-oncogene serine/threonine-protein kinase | EC 2.7.11.1; Proto-oncogene c-RAF; cRaf; Raf-1 | Homo sapiens (human) |
| Protein kinase C beta type | PKC-B; PKC-beta; EC 2.7.11.13 | Homo sapiens (human) |
| Tyrosine-protein kinase Lyn | EC 2.7.10.2; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn | Homo sapiens (human) |
| Protein kinase C alpha type | PKC-A; PKC-alpha; EC 2.7.11.13 | Homo sapiens (human) |
| Mitogen-activated protein kinase 3 | MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1 | Homo sapiens (human) |
| Tyrosine-protein kinase SYK | EC 2.7.10.2; Spleen tyrosine kinase; p72-Syk | Homo sapiens (human) |
| Dual specificity mitogen-activated protein kinase kinase 1 | MAP kinase kinase 1; MAPKK 1; MKK1; EC 2.7.12.2; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1 | Homo sapiens (human) |
| Tyrosine-protein kinase BTK | EC 2.7.10.2; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase | Homo sapiens (human) |
| Mitogen-activated protein kinase kinase kinase 1 | EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1 | Homo sapiens (human) |
| Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform | EC 3.1.3.16; CAM-PRP catalytic subunit; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform | Homo sapiens (human) |
| Nuclear factor of activated T-cells, cytoplasmic 1 | NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATc | Homo sapiens (human) |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1 | Homo sapiens (human) |
| Transcription factor AP-1 | Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 | Homo sapiens (human) |
| SHC-transforming protein 1 | SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1 | Homo sapiens (human) |
| Mitogen-activated protein kinase 8 | MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1 | Homo sapiens (human) |
| Growth factor receptor-bound protein 2 | Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2 | Homo sapiens (human) |
| Calmodulin-2 | | Homo sapiens (human) |
| Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit beta isoform; CNA beta | Homo sapiens (human) |
| Ras-related C3 botulinum toxin substrate 1 | EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1 | Homo sapiens (human) |
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform | Homo sapiens (human) |
| Son of sevenless homolog 1 | SOS-1 | Homo sapiens (human) |
| Nuclear factor of activated T-cells, cytoplasmic 2 | NF-ATc2; NFATc2; NFAT pre-existing subunit; NF-ATp; T-cell transcription factor NFAT1 | Homo sapiens (human) |
| GTPase HRas | EC 3.6.5.2; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras | Homo sapiens (human) |
| Calmodulin-1 | | Homo sapiens (human) |
| Calcium release-activated calcium channel protein 1 | Protein orai-1; Transmembrane protein 142A | Homo sapiens (human) |
| Proto-oncogene vav | | Homo sapiens (human) |
| Nuclear factor of activated T-cells, cytoplasmic 3 | NF-ATc3; NFATc3; NFATx; T-cell transcription factor NFAT4; NF-AT4; NF-AT4c | Homo sapiens (human) |
| Nuclear factor of activated T-cells, cytoplasmic 4 | NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3 | Homo sapiens (human) |
| Proto-oncogene c-Fos | Cellular oncogene fos; G0/G1 switch regulatory protein 7 | Homo sapiens (human) |
| ETS domain-containing protein Elk-1 | | Homo sapiens (human) |
| Calmodulin-3 | | Homo sapiens (human) |
| B-cell antigen receptor complex-associated protein alpha chain | Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein | Homo sapiens (human) |
| B-cell antigen receptor complex-associated protein beta chain | B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein | Homo sapiens (human) |
| B-cell linker protein | B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; SLP-65 | Homo sapiens (human) |
| Compound | Description |
|---|
| Orthophosphate | |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| inositol 1,4,5-trisphosphate | Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. |
| Phosphatidylinositol 4,5-Diphosphate | A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994) |