Page last updated: 2024-10-06

B cell receptor signaling pathway ( B cell receptor signaling )

Proteins (34)

ProteinSynonymsTaxonomy
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPI3-kinase subunit beta; PI3K-beta; PI3Kbeta; PtdIns-3-kinase subunit beta; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110betaRattus norvegicus (Norway rat)
Inhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16; TCF-16Homo sapiens (human)
Transcription factor p65 Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3Mus musculus (house mouse)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2EC 3.1.4.11; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2Rattus norvegicus (Norway rat)
Inositol 1,4,5-trisphosphate receptor type 3IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptorRattus norvegicus (Norway rat)
Protein kinase C beta typePKC-B; PKC-beta; EC 2.7.11.13Rattus norvegicus (Norway rat)
Inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; EC 2.7.11.10; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB; 2.7.11.1Rattus norvegicus (Norway rat)
Ubiquitin-conjugating enzyme E2 variant 1UEV-1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1AHomo sapiens (human)
Tyrosine-protein kinase SYKEC 2.7.10.2; Spleen tyrosine kinase; p72SykRattus norvegicus (Norway rat)
Mitogen-activated protein kinase kinase kinase mom-4EC 2.7.11.25Caenorhabditis elegans
Nuclear factor NF-kappa-B p105 subunit DNA-binding factor KBF1; EBP-1; NF-kappa-B1 p84/NF-kappa-B1 p98; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Mus musculus (house mouse)
Ubiquitin-conjugating enzyme E2 NEC 2.3.2.23; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubiquitin carrier protein N; Ubiquitin-protein ligase NRattus norvegicus (Norway rat)
Proto-oncogene tyrosine-protein kinase LCK EC 2.7.10.2; Lymphocyte cell-specific protein-tyrosine kinase; p56-LCKRattus norvegicus (Norway rat)
GTPase NRasEC 3.6.5.2; Transforming protein N-RasXenopus laevis (African clawed frog)
Immunoglobulin kappa constantIg kappa chain C region; Ig kappa chain C region AG; Ig kappa chain C region CUM; Ig kappa chain C region EU; Ig kappa chain C region OU; Ig kappa chain C region ROY; Ig kappa chain C region TIHomo sapiens (human)
Immunoglobulin heavy constant deltaIg delta chain C region; Ig delta chain C region NIG-65; Ig delta chain C region WAHHomo sapiens (human)
B-cell antigen receptor complex-associated protein alpha chain Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated proteinMus musculus (house mouse)
B-cell antigen receptor complex-associated protein beta chain B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 proteinMus musculus (house mouse)
B-lymphocyte antigen CD19Differentiation antigen CD19Mus musculus (house mouse)
Proto-oncogene vav p95vavMus musculus (house mouse)
Mitogen-activated protein kinase ERK-AEC 2.7.11.24; Extracellular-regulated kinase A; Protein rolledDrosophila melanogaster (fruit fly)
TNF receptor-associated factor 6 EC 2.3.2.27; E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6Mus musculus (house mouse)
Raf homolog serine/threonine-protein kinaseEC 2.7.11.1; Abnormal cell lineage protein 45Caenorhabditis elegans
Dual specificity mitogen-activated protein kinase kinase mek-2MAP kinase kinase mek-2; EC 2.7.12.2Caenorhabditis elegans
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homologEC 3.4.22.-; ParacaspaseMus musculus (house mouse)
NF-kappa-B inhibitor alpha I-kappa-B-alpha; IkB-alpha; IkappaBalpha; RL/IF-1Rattus norvegicus (Norway rat)
Phosphatidylinositol 3-kinase regulatory subunit alpha PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaRattus norvegicus (Norway rat)
B-cell linker proteinB-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; SLP-65Homo sapiens (human)
Caspase recruitment domain-containing protein 11CARD-containing MAGUK protein 1; Carma 1Homo sapiens (human)
NF-kappa-B essential modulatorInhibitor of nuclear factor kappa B kinase subunit gamma; DmIKKgamma; NEMO homologDrosophila melanogaster (fruit fly)
Son of sevenless homologGuanine nucleotide exchange factor for RASCaenorhabditis elegans
B-cell lymphoma/leukemia 10B-cell CLL/lymphoma 10; Bcl-10; R-RCD1; RCDRattus norvegicus (Norway rat)
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidehDAPP1; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDaHomo sapiens (human)
Growth factor receptor-bound protein 2-BAdapter protein GRB2-B; SH2/SH3 adapter GRB2-BXenopus laevis (African clawed frog)

Compounds (4)

CompoundDescription
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
guanosine triphosphateGuanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.
inositol 1,4,5-trisphosphateIntracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.