Page last updated: 2024-10-06

Arginine and Proline metabolism ( Arginine and Proline metabolism )

Proteins (42)

ProteinSynonymsTaxonomy
Arginine--tRNA ligase, cytoplasmicEC 6.1.1.19; Arginyl-tRNA synthetase; ArgRSHomo sapiens (human)
Aspartate aminotransferase, mitochondrialmAspAT; EC 2.6.1.1; EC 2.6.1.7; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; PlHomo sapiens (human)
4-trimethylaminobutyraldehyde dehydrogenaseTMABA-DH; TMABALDH; EC 1.2.1.47; Aldehyde dehydrogenase E3 isozyme; Aldehyde dehydrogenase family 9 member A1; 1.2.1.3; Gamma-aminobutyraldehyde dehydrogenase; 1.2.1.19; R-aminobutyraldehyde dehydrogenaseHomo sapiens (human)
Glutamate dehydrogenase 2, mitochondrialGDH 2; EC 1.4.1.3Homo sapiens (human)
Aldehyde dehydrogenase family 3 member A2EC 1.2.1.3; EC 1.2.1.94; Aldehyde dehydrogenase 10; Fatty aldehyde dehydrogenase; Microsomal aldehyde dehydrogenaseHomo sapiens (human)
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialP5C dehydrogenase; EC 1.2.1.88; Aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenaseHomo sapiens (human)
Amine oxidase [flavin-containing] AEC 1.4.3.4; Monoamine oxidase type A; MAO-AHomo sapiens (human)
Nitric oxide synthase, inducibleEC 1.14.13.39; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2Homo sapiens (human)
Prolyl 4-hydroxylase subunit alpha-14-PH alpha-1; EC 1.14.11.2; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1Homo sapiens (human)
S-adenosylmethionine decarboxylase proenzymeAdoMetDC; SAMDC; EC 4.1.1.50Homo sapiens (human)
Amine oxidase [flavin-containing] BEC 1.4.3.4; Monoamine oxidase type B; MAO-BHomo sapiens (human)
Nitric oxide synthase, brainEC 1.14.13.39; Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS; N-NOS; nNOS; Peptidyl-cysteine S-nitrosylase NOS1; bNOSHomo sapiens (human)
Pyrroline-5-carboxylate reductase 1, mitochondrialP5C reductase 1; P5CR 1; EC 1.5.1.2Homo sapiens (human)
Retinal dehydrogenase 1RALDH 1; RalDH1; EC 1.2.1.-; EC 1.2.1.36; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolicHomo sapiens (human)
Ornithine aminotransferase, mitochondrialEC 2.6.1.13; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferaseHomo sapiens (human)
Aldehyde dehydrogenase, mitochondrialEC 1.2.1.3; ALDH class 2; ALDH-E2; ALDHIHomo sapiens (human)
Creatine kinase M-typeEC 2.7.3.2; Creatine kinase M chain; Creatine phosphokinase M-type; CPK-M; M-CKHomo sapiens (human)
Ornithine decarboxylaseODC; EC 4.1.1.17Homo sapiens (human)
Creatine kinase B-typeEC 2.7.3.2; Brain creatine kinase; B-CK; Creatine kinase B chain; Creatine phosphokinase B-type; CPK-BHomo sapiens (human)
Spermidine synthaseSPDSY; EC 2.5.1.16; Putrescine aminopropyltransferaseHomo sapiens (human)
Aspartate aminotransferase, cytoplasmiccAspAT; EC 2.6.1.1; EC 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase AHomo sapiens (human)
Diamine acetyltransferase 1EC 2.3.1.57; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; Spermidine/spermine N(1)-acetyltransferase 1; SSAT; SSAT-1Homo sapiens (human)
Guanidinoacetate N-methyltransferaseEC 2.1.1.2Homo sapiens (human)
Retina-specific copper amine oxidaseRAO; EC 1.4.3.21; Amine oxidase [copper-containing]; Semicarbazide-sensitive amine oxidase; SSAOHomo sapiens (human)
Arginase-1EC 3.5.3.1; Liver-type arginase; Type I arginaseHomo sapiens (human)
Nitric oxide synthase, endothelialEC 1.14.13.39; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIIIHomo sapiens (human)
Arginase-2, mitochondrialEC 3.5.3.1; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginaseHomo sapiens (human)
Membrane primary amine oxidaseEC 1.4.3.21; Copper amine oxidase; HPAO; Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1Homo sapiens (human)
Ornithine transcarbamylase, mitochondrialOTCase; EC 2.1.3.3; Ornithine carbamoyltransferase, mitochondrialHomo sapiens (human)
Bifunctional glutamate/proline--tRNA ligaseBifunctional aminoacyl-tRNA synthetase; Cell proliferation-inducing gene 32 protein; Glutamatyl-prolyl-tRNA synthetaseHomo sapiens (human)
Spermine synthaseSPMSY; EC 2.5.1.22; Spermidine aminopropyltransferaseHomo sapiens (human)
Amiloride-sensitive amine oxidase [copper-containing]DAO; Diamine oxidase; EC 1.4.3.22; Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase; KAOHomo sapiens (human)
Aldehyde dehydrogenase X, mitochondrialEC 1.2.1.3; Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1Homo sapiens (human)
Prolyl 4-hydroxylase subunit alpha-24-PH alpha-2; EC 1.14.11.2; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2Homo sapiens (human)
Argininosuccinate synthaseEC 6.3.4.5; Citrulline--aspartate ligaseHomo sapiens (human)
Pyrroline-5-carboxylate reductase 3P5C reductase 3; P5CR 3; EC 1.5.1.2; Pyrroline-5-carboxylate reductase-like proteinHomo sapiens (human)
Creatine kinase U-type, mitochondrialEC 2.7.3.2; Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCKHomo sapiens (human)
Creatine kinase S-type, mitochondrialEC 2.7.3.2; Basic-type mitochondrial creatine kinase; Mib-CK; Sarcomeric mitochondrial creatine kinase; S-MtCKHomo sapiens (human)
Glutamate dehydrogenase 1, mitochondrialGDH 1; EC 1.4.1.3Homo sapiens (human)
Argininosuccinate lyaseASAL; EC 4.3.2.1; ArginosuccinaseHomo sapiens (human)
Alpha-aminoadipic semialdehyde dehydrogenaseAlpha-AASA dehydrogenase; EC 1.2.1.31; Aldehyde dehydrogenase family 7 member A1; 1.2.1.3; Antiquitin-1; Betaine aldehyde dehydrogenase; 1.2.1.8; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenaseHomo sapiens (human)
Glycine amidinotransferase, mitochondrialEC 2.1.4.1; L-arginine:glycine amidinotransferase; TransamidinaseHomo sapiens (human)

Compounds (48)

CompoundDescription
phosphoric acidconcise etchant is 37% H3PO4
diphosphoric acid
succinic acidA water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
ureaA compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
gamma-aminobutyric acidThe most common inhibitory neurotransmitter in the central nervous system.
Nitric OxideA free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
NADH
fumaric acidsee also record for ferrous fumarate; use FUMARATES for general fumaric acid esters
creatineAn amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
aspartic acidOne of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
ornithineAn amino acid produced in the urea cycle by the splitting off of urea from arginine.
arginineAn essential amino acid that is physiologically active in the L-form.
glycineA non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
phosphocreatineAn endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996)
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
spermidineA polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
spermineA biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
4-aminobutyraldehyde
prolineA non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
Argininosuccinic AcidThis amino acid is formed during the urea cycle from citrulline, aspartate and ATP. This reaction is catalyzed by argininosuccinic acid synthetase.
glutamic acid gamma-semialdehydestraight-chain form of delta(1)-pyrroline-5-carboxylate; RN given refers to cpd with unspecified isomeric designation
carbamyl phosphateThe monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).
5'-methylthioadenosinestructure
s-adenosyl-3-methylthiopropylaminedecarboxylated S-adenosylmethionine
delta-1-pyrroline-5-carboxylate(L)-isomer is the biologically active form; RN given refers to cpd without isomeric designation; structure
N(2)-succinylglutamate
alpha-ketoglutaric acid
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
2-keto-4-hydroxyglutarateRN given refers to parent cpd
glycocyamineRN given refers to parent cpd; structure
putrescineA toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.
n-acetylputrescine
N(2)-succinylornithine
s-adenosylhomocysteine5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
hydroxyprolineA hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
creolinfrom refined coal tar oils
coenzyme a
citrulline