Page last updated: 2024-10-06

Arginine Metabolism

Proteins (28)

ProteinSynonymsTaxonomy
Acetylornithine/succinyldiaminopimelate aminotransferaseACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17Escherichia coli K-12
Carbamoyl-phosphate synthase small chainEC 6.3.5.5; Carbamoyl-phosphate synthetase glutamine chainEscherichia coli K-12
4-aminobutyrate aminotransferase GabTEC 2.6.1.19; 5-aminovalerate transaminase; 2.6.1.48; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBATEscherichia coli K-12
Succinate-semialdehyde dehydrogenase [NADP(+)] GabDSSDH; EC 1.2.1.79; Glutarate-semialdehyde dehydrogenase; 1.2.1.-Escherichia coli K-12
Putrescine aminotransferasePAT; PATase; EC 2.6.1.82; Cadaverine transaminase; Diamine transaminase; 2.6.1.29; Putrescine transaminase; Putrescine--2-oxoglutaric acid transaminase; Putrescine:2-OG aminotransferaseEscherichia coli K-12
4-aminobutyrate aminotransferase PuuEEC 2.6.1.19; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminaseEscherichia coli K-12
Gamma-aminobutyraldehyde dehydrogenaseABALDH; EC 1.2.1.19; 1-pyrroline dehydrogenase; 4-aminobutanal dehydrogenase; 5-aminopentanal dehydrogenase; 1.2.1.-Escherichia coli K-12
Succinate semialdehyde dehydrogenase [NAD(P)+] SadSSADH; SSDH; EC 1.2.1.16Escherichia coli K-12
Argininosuccinate synthaseEC 6.3.4.5; Citrulline--aspartate ligaseEscherichia coli K-12
AgmatinaseEC 3.5.3.11; Agmatine ureohydrolase; AUHEscherichia coli K-12
Biodegradative arginine decarboxylaseADC; EC 4.1.1.19Escherichia coli K-12
Acetylglutamate kinaseEC 2.7.2.8; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGKEscherichia coli K-12
Acetylornithine deacetylaseAO; Acetylornithinase; EC 3.5.1.16; N-acetylornithinase; NAOEscherichia coli K-12
N-succinylglutamate 5-semialdehyde dehydrogenaseEC 1.2.1.71; Succinylglutamic semialdehyde dehydrogenase; SGSDEscherichia coli K-12
Arginine N-succinyltransferaseAST; EC 2.3.1.109; AOSTEscherichia coli K-12
Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuDGamma-Glu-GABA hydrolase; EC 3.5.1.94Escherichia coli K-12
NADP/NAD-dependent aldehyde dehydrogenase PuuCALDH; EC 1.2.1.5; 3-hydroxypropionaldehyde dehydrogenase; Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Gamma-Glu-gamma-aminobutyraldehyde dehydrogenaseEscherichia coli K-12
Carbamoyl-phosphate synthase large chainEC 6.3.5.5; Carbamoyl-phosphate synthetase ammonia chainEscherichia coli K-12
Ornithine carbamoyltransferase subunit IOTCase-1; EC 2.1.3.3Escherichia coli K-12
Ornithine carbamoyltransferase subunit FOTCase-2; EC 2.1.3.3Escherichia coli K-12
N-acetyl-gamma-glutamyl-phosphate reductaseAGPR; EC 1.2.1.38; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenaseEscherichia coli K-12
Argininosuccinate lyaseASAL; EC 4.3.2.1; ArginosuccinaseEscherichia coli K-12
Gamma-glutamylputrescine oxidoreductaseGamma-Glu-Put oxidase; Gamma-glutamylputrescine oxidase; EC 1.4.3.-Escherichia coli K-12
Succinylglutamate desuccinylaseEC 3.5.1.96Escherichia coli K-12
N-succinylarginine dihydrolaseEC 3.5.3.23Escherichia coli K-12
Succinylornithine transaminaseSOAT; EC 2.6.1.81; Carbon starvation protein C; Succinylornithine aminotransferaseEscherichia coli K-12
Gamma-glutamylputrescine synthetase PuuAGamma-Glu-Put synthetase; EC 6.3.1.11; Glutamate--putrescine ligaseEscherichia coli K-12
Peroxisome proliferator-activated receptor gamma Homo sapiens (human)

Compounds (35)

CompoundDescription
hydronium ion
Orthophosphate
succinic acidA water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
ureaA compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
gamma-aminobutyric acidThe most common inhibitory neurotransmitter in the central nervous system.
acetic acidProduct of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
glutamineA non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
ornithineAn amino acid produced in the urea cycle by the splitting off of urea from arginine.
hydrogen carbonate
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Coenzyme A
succinic semialdehydestructure
4-aminobutyraldehyde
Argininosuccinic AcidThis amino acid is formed during the urea cycle from citrulline, aspartate and ATP. This reaction is catalyzed by argininosuccinic acid synthetase.
N-acetylglutamate, (DL)-isomer
N-acetyl-L-glutamic acid gamma-semialdehyde
agmatineDecarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.
carbamyl phosphateThe monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).
alpha-ketoglutaric acid
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
putrescineA toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.
N(2)-succinylornithine
gamma glutamyl GABAstructure given in first source
N(delta)-acetylornithineRN given refers to (L)-isomer
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
creolinfrom refined coal tar oils
pyrophosphate