Antimicrobial action and antimicrobial resistance in Mtb

Proteins (4)

Protein	Synonyms	Taxonomy
DNA-directed RNA polymerase subunit alpha	RNAP subunit alpha; EC 2.7.7.6; RNA polymerase subunit alpha; Transcriptase subunit alpha	Mycobacterium tuberculosis H37Rv
DNA-directed RNA polymerase subunit beta	RNAP subunit beta; EC 2.7.7.6; RNA polymerase subunit beta; Transcriptase subunit beta	Mycobacterium tuberculosis H37Rv
DNA-directed RNA polymerase subunit omega	RNAP omega subunit; EC 2.7.7.6; RNA polymerase omega subunit; Transcriptase subunit omega	Mycobacterium tuberculosis H37Rv
DNA-directed RNA polymerase subunit beta'	RNAP subunit beta'; EC 2.7.7.6; RNA polymerase subunit beta'; Transcriptase subunit beta'	Mycobacterium tuberculosis H37Rv

Compounds (1)

Compound	Description
rifampin	A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)

Compound

Description

rifampin

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)