Page last updated: 2024-10-06

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Proteins (23)

ProteinSynonymsTaxonomy
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPI3-kinase subunit delta; PI3K-delta; PI3Kdelta; PtdIns-3-kinase subunit delta; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta; p110deltaHomo sapiens (human)
Tyrosine-protein kinase SYKEC 2.7.10.2; Spleen tyrosine kinase; p72-SykHomo sapiens (human)
Tyrosine-protein kinase BTKEC 2.7.10.2; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinaseHomo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2EC 3.1.4.11; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2Homo sapiens (human)
B-cell receptor CD22B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14Homo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaHomo sapiens (human)
Short transient receptor potential channel 1TrpC1; Transient receptor protein 1; TRP-1Homo sapiens (human)
Stromal interaction molecule 1Homo sapiens (human)
S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2; AdoHcyase 2Homo sapiens (human)
Cytoplasmic protein NCK1NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alphaHomo sapiens (human)
Son of sevenless homolog 1SOS-1Homo sapiens (human)
Calmodulin-1Homo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 6EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1Homo sapiens (human)
Calcium release-activated calcium channel protein 1Protein orai-1; Transmembrane protein 142AHomo sapiens (human)
Protein orai-2CAP-binding protein complex-interacting protein 2; Transmembrane protein 142BHomo sapiens (human)
Proto-oncogene vavHomo sapiens (human)
SH3 domain-containing kinase-binding protein 1CD2-binding protein 3; CD2BP3; Cbl-interacting protein of 85 kDa; Human Src family kinase-binding protein 1; HSB-1Homo sapiens (human)
Phosphoinositide 3-kinase adapter protein 1B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1Homo sapiens (human)
B-cell antigen receptor complex-associated protein alpha chainIg-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated proteinHomo sapiens (human)
B-lymphocyte antigen CD19B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12Homo sapiens (human)
B-cell antigen receptor complex-associated protein beta chainB-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 proteinHomo sapiens (human)
B-cell linker proteinB-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; SLP-65Homo sapiens (human)
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidehDAPP1; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDaHomo sapiens (human)

Compounds (4)

CompoundDescription
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.