Pathways > Androstenedione Metabolism
Page last updated: 2024-10-06

Androstenedione Metabolism

Proteins (18)

ProteinSynonymsTaxonomy
Protein disulfide-isomerase A4EC 5.3.4.1; Endoplasmic reticulum resident protein 70; ER protein 70; ERp70; Endoplasmic reticulum resident protein 72; ER protein 72; ERp-72; ERp72Homo sapiens (human)
Aldo-keto reductase family 1 member C4EC 1.1.1.-; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; 3-alpha-hydroxysteroid dehydrogenase type I; 3-alpha-HSD1; 1.1.1.357; 3alpha-hydroxysteroid 3-dehydrogenase; Chlordecone reductase; CDR; 1.1.1.225; Dihydrodiol dehydrogenase 4;Homo sapiens (human)
Corticosteroid 11-beta-dehydrogenase isozyme 1EC 1.1.1.146; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; Short chain dehydrogenase/reductase family 26C member 1Homo sapiens (human)
Protein disulfide-isomerase A2EC 5.3.4.1; Pancreas-specific protein disulfide isomerase; PDIpHomo sapiens (human)
AromataseEC 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthaseHomo sapiens (human)
Cytochrome P450 11B1, mitochondrialCYPXIB1; Cytochrome P-450c11; Cytochrome P450C11; Steroid 11-beta-hydroxylase, CYP11B1; 1.14.15.4Homo sapiens (human)
Peptidyl-prolyl cis-trans isomerase BPPIase B; EC 5.2.1.8; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLPHomo sapiens (human)
Endoplasmic reticulum chaperone BiPEC 3.6.4.10; 78 kDa glucose-regulated protein; GRP-78; Binding-immunoglobulin protein; BiP; Heat shock protein 70 family protein 5; HSP70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding proteinHomo sapiens (human)
3-oxo-5-alpha-steroid 4-dehydrogenase 1EC 1.3.1.22; SR type 1; Steroid 5-alpha-reductase 1; S5AR 1Homo sapiens (human)
UDP-glucuronosyltransferase 1A1 UGT1A1; EC 2.4.1.17; Bilirubin-specific UDPGT isozyme 1; hUG-BR1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UDP-glucuronosyltransferase 1A isoform 1Homo sapiens (human)
Testosterone 17-beta-dehydrogenase 3EC 1.1.1.64; 17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Estradiol 17-beta-dehydrogenase 2; 1.1.1.62; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17-beta-hydroxysteroid dehydrogenaseHomo sapiens (human)
Protein disulfide-isomerase A6EC 5.3.4.1; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7Homo sapiens (human)
Endoplasmic reticulum resident protein 29ERp29; Endoplasmic reticulum resident protein 28; ERp28; Endoplasmic reticulum resident protein 31; ERp31Homo sapiens (human)
Aldo-keto reductase family 1 member D1EC 1.3.1.3; 3-oxo-5-beta-steroid 4-dehydrogenase; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductaseHomo sapiens (human)
Stromal cell-derived factor 2-like protein 1SDF2-like protein 1; PWP1-interacting protein 8Homo sapiens (human)
DnaJ homolog subfamily B member 11APOBEC1-binding protein 2; ABBP-2; DnaJ protein homolog 9; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; Endoplasmic reticulum DNA J domain-containing protein 3; ER-resident protein ERdj3; ERdj3; ERj3p; HEDJ; Human DnaJ protein 9; hDj-9; PWP1-inteHomo sapiens (human)
HYOU1 proteinHomo sapiens (human)
Endoplasmin Homo sapiens (human)

Compounds (20)

CompoundDescription
hydronium ion
NADH
estroneAn aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
TestosteroneA potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
uridine diphosphate glucuronic acidA nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones.
19-hydroxy-4-androstene-3,17-dione
androstane-3,17-dione, (5beta)-isomer
etiocholanolone glucuronide
androsteroneA metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.
etiocholanoloneThe 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
androsterone glucuronideRN given refers to (3alpha,5alpha)-isomer
androstane-3,17-dione, (5alpha)-isomer
adrenosterone
creolinfrom refined coal tar oils
androstenedioneA delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
11-hydroxyandrostenedione, (11beta)-isomer
chemdatabank.com