Page last updated: 2024-10-06

Androgen receptor network in prostate cancer

Proteins (41)

ProteinSynonymsTaxonomy
Serine/threonine-protein kinase Chk1EC 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1Homo sapiens (human)
Interstitial collagenaseEC 3.4.24.7; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Cyclin-dependent kinase 1CDK1; EC 2.7.11.22; EC 2.7.11.23; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinaseHomo sapiens (human)
G1/S-specific cyclin-D1B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogeneHomo sapiens (human)
Cyclin-dependent kinase 2EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinaseHomo sapiens (human)
RAC-alpha serine/threonine-protein kinaseEC 2.7.11.1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alphaHomo sapiens (human)
Caspase-8CASP-8; EC 3.4.22.61; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACHHomo sapiens (human)
DNA mismatch repair protein Msh6hMSH6; G/T mismatch-binding protein; GTBP; GTMBP; MutS protein homolog 6; MutS-alpha 160 kDa subunit; p160Homo sapiens (human)
Double-strand break repair protein MRE11EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog AHomo sapiens (human)
Serine/threonine-protein kinase Chk2EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2Homo sapiens (human)
Apoptosis regulator Bcl-2Homo sapiens (human)
Cyclin-dependent kinase 4EC 2.7.11.22; Cell division protein kinase 4; PSK-J3Homo sapiens (human)
Tyrosine-protein kinase JAK1EC 2.7.10.2; Janus kinase 1; JAK-1Homo sapiens (human)
Serine/threonine-protein kinase mTOREC 2.7.11.1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1Homo sapiens (human)
Caspase-3CASP-3; EC 3.4.22.56; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1Homo sapiens (human)
Caspase-9CASP-9; EC 3.4.22.62; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6Homo sapiens (human)
DNA-dependent protein kinase catalytic subunitDNA-PK catalytic subunit; DNA-PKcs; EC 2.7.11.1; DNPK1; p460Homo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
Apoptosis regulator BAX Bcl-2-like protein 4; Bcl2-L-4Homo sapiens (human)
Bcl2-associated agonist of cell death BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell deathHomo sapiens (human)
DNA mismatch repair protein Msh2hMSH2; MutS protein homolog 2Homo sapiens (human)
BRCA1-associated RING domain protein 1BARD-1; EC 2.3.2.27; RING-type E3 ubiquitin transferase BARD1Homo sapiens (human)
Myc proto-oncogene proteinClass E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64Homo sapiens (human)
Retinoblastoma-associated protein p105-Rb; p110-RB1; pRb; Rb; pp110Homo sapiens (human)
Breast cancer type 1 susceptibility proteinEC 2.3.2.27; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1Homo sapiens (human)
Signal transducer and activator of transcription 1-alpha/betaTranscription factor ISGF-3 components p91/p84Homo sapiens (human)
Bloom syndrome proteinEC 3.6.4.12; DNA helicase, RecQ-like type 2; RecQ2; RecQ protein-like 3Homo sapiens (human)
Mothers against decapentaplegic homolog 3MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3Homo sapiens (human)
Transcription factor E2F1E2F-1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1Homo sapiens (human)
Serine-protein kinase ATMEC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutatedHomo sapiens (human)
Serine/threonine-protein kinase ATREC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1Homo sapiens (human)
Mothers against decapentaplegic homolog 2MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2Homo sapiens (human)
Regulatory-associated protein of mTORRaptor; p150 target of rapamycin (TOR)-scaffold proteinHomo sapiens (human)
Eukaryotic translation initiation factor 4E-binding protein 14E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-IHomo sapiens (human)
GTP-binding protein RhebRas homolog enriched in brainHomo sapiens (human)
DNA repair protein RAD50hRAD50; EC 3.6.-.-Homo sapiens (human)
TuberinTuberous sclerosis 2 proteinHomo sapiens (human)
NADPH oxidase activator 1NOX activator 1; Antigen NY-CO-31; NCF2-like protein; P67phox-like factor; p51-noxHomo sapiens (human)
HamartinTuberous sclerosis 1 proteinHomo sapiens (human)
Cation-transporting ATPase Homo sapiens (human)

Compounds (4)

CompoundDescription
dihydrotestosteroneA potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.
4-androstene-3,17-diolRN given refers to (3alpha,17beta)-isomer
17-alpha-hydroxyprogesteroneA metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.
17-alpha-hydroxypregnenoloneA 21-carbon steroid that is converted from PREGNENOLONE by STEROID 17-ALPHA-HYDROXYLASE. It is an intermediate in the delta-5 pathway of biosynthesis of GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.