Page last updated: 2024-10-06

ACE Inhibitor Pathway, Pharmacodynamics

Proteins (14)

ProteinSynonymsTaxonomy
ReninEC 3.4.23.15; AngiotensinogenaseHomo sapiens (human)
Cathepsin GCG; EC 3.4.21.20Homo sapiens (human)
NeprilysinEC 3.4.24.11; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFEHomo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Type-1 angiotensin II receptorAT1AR; AT1BR; Angiotensin II type-1 receptor; AT1Homo sapiens (human)
Cytochrome P450 11B2, mitochondrialAldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; CYPXIB2; Corticosterone 18-monooxygenase, CYP11B2; 1.14.15.5; Cytochrome P-450Aldo; Cytochrome P-450C18; Steroid 11-beta-hydroxylase, CYP11B2; 1.14.15.4; Steroid 18-hydroxylaseHomo sapiens (human)
B2 bradykinin receptorB2R; BK-2 receptorHomo sapiens (human)
B1 bradykinin receptorB1R; BK-1 receptorHomo sapiens (human)
Type-2 angiotensin II receptorAngiotensin II type-2 receptor; AT2Homo sapiens (human)
Proto-oncogene MasHomo sapiens (human)
ChymaseEC 3.4.21.39; Alpha-chymase; Mast cell protease IHomo sapiens (human)
Transforming growth factor beta-1 proproteinHomo sapiens (human)
Angiotensin 1-10 Homo sapiens (human)
Nitric-oxide synthase Homo sapiens (human)

Compounds (4)

CompoundDescription
angiotensin ii, des-phe(8)-
AngiotensinsOligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANGIOTENSIN SYSTEM. These include angiotensins derived naturally from precursor ANGIOTENSINOGEN, and those synthesized.
angiotensin iA decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.
angiotensin i, ile(5)-