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4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis

Proteins (12)

ProteinSynonymsTaxonomy
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20EC 2.7.1.49; EC 2.7.4.7; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinaseSaccharomyces cerevisiae S288C
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21EC 2.7.1.49; EC 2.7.4.7; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinaseSaccharomyces cerevisiae S288C
AmidophosphoribosyltransferaseATase; EC 2.4.2.14; Glutamine phosphoribosylpyrophosphate amidotransferaseSaccharomyces cerevisiae S288C
Putative pyridoxal kinase BUD16EC 2.7.1.35; Bud site selection protein 16Saccharomyces cerevisiae S288C
Pyridoxamine 5'-phosphate oxidaseEC 1.4.3.5; PNP/PMP oxidase; PNPOxSaccharomyces cerevisiae S288C
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI12HMP-P synthase; Hydroxymethylpyrimidine phosphate synthase; EC 2.-.-.-; Thiamine biosynthesis protein 12; Thiamine pyrimidine synthaseSaccharomyces cerevisiae S288C
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5HMP-P synthase; Hydroxymethylpyrimidine phosphate synthase; EC 2.-.-.-; Thiamine biosynthesis protein 5; Thiamine pyrimidine synthaseSaccharomyces cerevisiae S288C
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI11HMP-P synthase; Hydroxymethylpyrimidine phosphate synthase; EC 2.-.-.-; Thiamine biosynthesis protein 11; Thiamine pyrimidine synthaseSaccharomyces cerevisiae S288C
Pyridoxamine 5'-phosphate oxidase YLR456W homologPNP/PMP oxidase YLR456W homolog; PNPOx YLR456W homologSaccharomyces cerevisiae S288C
Putative pyridoxal reductasePL reductase; PL-red; EC 1.1.1.65Saccharomyces cerevisiae S288C
Pyridoxamine 5'-phosphate oxidase homologPNP/PMP oxidase homolog; PNPOx homologSaccharomyces cerevisiae S288C
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13HMP-P synthase; Hydroxymethylpyrimidine phosphate synthase; EC 2.-.-.-; Thiamine biosynthesis protein 13; Thiamine pyrimidine synthaseSaccharomyces cerevisiae S288C

Compounds (21)

CompoundDescription
diphosphoric acid
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
pyridoxalThe 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.
pyridoxineThe 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
3-hydroxy-2,4,5-trihydroxymethylpyridineprecursor substrate for pyridoxine synthesis by Kloeckera apiculate (yeast); RN given refers to parent cpd; structure
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer