Pathways > 3-phosphoinositide biosynthesis
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3-phosphoinositide biosynthesis

Proteins (29)

ProteinSynonymsTaxonomy
Phosphatidylinositol 3-kinase regulatory subunit betaPI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PI3-kinase subunit p85-beta; PtdIns-3-kinase regulatory subunit p85-betaHomo sapiens (human)
Phosphatidylinositol 4-phosphate 5-kinase type-1 betaPIP5K1-beta; PtdIns(4)P-5-kinase 1 beta; EC 2.7.1.68; Phosphatidylinositol 4-phosphate 5-kinase type I beta; PIP5KIbeta; Protein STM-7; Type I phosphatidylinositol 4-phosphate 5-kinase betaHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPI3-kinase subunit delta; PI3K-delta; PI3Kdelta; PtdIns-3-kinase subunit delta; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta; p110deltaHomo sapiens (human)
Phosphatidylinositol 4-phosphate 5-kinase type-1 gammaPIP5K1gamma; PtdIns(4)P-5-kinase 1 gamma; EC 2.7.1.68; Type I phosphatidylinositol 4-phosphate 5-kinase gammaHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; EC 2.7.1.137; EC 2.7.1.153; EC 2.7.1.154; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PtdIns-3-kinase subunit p110-gamma; p110gamma; PhosphHomo sapiens (human)
Phosphatidylinositol 3-kinase catalytic subunit type 3PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; EC 2.7.1.137; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34Homo sapiens (human)
Phosphatidylinositol 4-kinase betaPI4K-beta; PI4Kbeta; PtdIns 4-kinase beta; EC 2.7.1.67; NPIK; PI4K92; PI4KIIIHomo sapiens (human)
1-phosphatidylinositol 3-phosphate 5-kinasePhosphatidylinositol 3-phosphate 5-kinase; EC 2.7.1.150; FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III; PIPkin-III; Type III PIP kinase; Serine-protein kinase PIKFYVE; 2.7.11.1Homo sapiens (human)
Phosphatidylinositol 4-kinase type 2-betaEC 2.7.1.67; Phosphatidylinositol 4-kinase type II-beta; PI4KII-BETAHomo sapiens (human)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaPI3K-C2-beta; PtdIns-3-kinase C2 subunit beta; EC 2.7.1.137; EC 2.7.1.154; C2-PI3K; Phosphoinositide 3-kinase-C2-betaHomo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPI3-kinase subunit beta; PI3K-beta; PI3Kbeta; PtdIns-3-kinase subunit beta; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110betaHomo sapiens (human)
Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaPIP5K1-alpha; PtdIns(4)P-5-kinase 1 alpha; EC 2.7.1.68; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; PIP5KIalphaHomo sapiens (human)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammaPI3K-C2-gamma; PtdIns-3-kinase C2 subunit gamma; EC 2.7.1.154; Phosphoinositide 3-kinase-C2-gammaHomo sapiens (human)
Phosphoinositide 3-kinase regulatory subunit 4PI3-kinase regulatory subunit 4; EC 2.7.11.1; PI3-kinase p150 subunit; Phosphoinositide 3-kinase adaptor proteinHomo sapiens (human)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alphaPI3K-C2-alpha; PtdIns-3-kinase C2 subunit alpha; EC 2.7.1.137; EC 2.7.1.153; EC 2.7.1.154; Phosphoinositide 3-kinase-C2-alphaHomo sapiens (human)
Phosphatidylinositol 4-kinase alphaPI4-kinase alpha; PI4K-alpha; PtdIns-4-kinase alpha; EC 2.7.1.67; Phosphatidylinositol 4-Kinase III alphaHomo sapiens (human)
Phosphatidylinositol 4-kinase type 2-alphaEC 2.7.1.67; Phosphatidylinositol 4-kinase type II-alphaHomo sapiens (human)
Phosphoinositide 3-kinase regulatory subunit 5PI3-kinase regulatory subunit 5; PI3-kinase p101 subunit; Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; PtdIns-3-kinase p101; p101-PI3KHomo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit gammaPI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIKHomo sapiens (human)
Polyphosphoinositide phosphataseEC 3.1.3.-; Factor-induced gene 4 protein; Phosphatidylinositol 3,5-bisphosphate 5-phosphataseSaccharomyces cerevisiae S288C
Polyphosphoinositide phosphataseEC 3.1.3.-; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; SAC domain-containing protein 3Homo sapiens (human)
1-phosphatidylinositol 3-phosphate 5-kinase FAB1Phosphatidylinositol 3-phosphate 5-kinase; EC 2.7.1.150; Type III PIP kinase; PIPkin-IIISaccharomyces cerevisiae S288C
CDP-diacylglycerol--inositol 3-phosphatidyltransferaseEC 2.7.8.11; Phosphatidylinositol synthase; PI synthase; PtdIns synthaseHomo sapiens (human)
CDP-diacylglycerol--inositol 3-phosphatidyltransferaseEC 2.7.8.11; Phosphatidylinositol synthase; PI synthase; PtdIns synthaseSaccharomyces cerevisiae S288C
Phosphatidylinositol-3-phosphatase SAC1EC 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Recessive suppressor of secretory defectSaccharomyces cerevisiae S288C
Phosphoinositide 3-kinase regulatory subunit 6Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p84 PI3K adapter protein; p84 PIKAP; p87 PI3K adapter protein; p87PIKAPHomo sapiens (human)
Phosphatidylinositol-3-phosphatase SAC1EC 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like proteinHomo sapiens (human)

Compounds (17)

CompoundDescription
diphosphoric acid
hydronium ion
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
inositolAn isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Cytidine MonophosphateCytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
wortmanninAn androstadiene metabolite produced by the fungi PENICILLIUM funiculosum that inhibits PHOSPHATIDYLINOSITOL-3-KINASES and alloantigen-specific activation of T-LYMPHOCYTES in human tumor cell lines. It is widely used in CELL BIOLOGY research and has broad therapeutic potential.
SpermineA biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
Phosphatidylinositol 4,5-DiphosphateA phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
phosphatidylinositol 4-phosphate
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