Page last updated: 2024-10-06

(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)

Proteins (7)

ProteinSynonymsTaxonomy
Acetoacetyl-CoA reductaseCupriavidus necator
3-hydroxybutyryl-CoA dehydrogenaseEC 1.1.1.157; Beta-hydroxybutyryl-CoA dehydrogenase; BHBDClostridium acetobutylicum ATCC 824
Acyl-CoA thioesterase 2EC 3.1.2.20; Thioesterase II; TEIIEscherichia coli K-12
Acetyl-CoA acetyltransferaseEC 2.3.1.9; Acetoacetyl-CoA thiolase; Beta-ketothiolaseCupriavidus necator H16
Acetyl-CoA acetyltransferaseEC 2.3.1.9; Acetoacetyl-CoA thiolaseClostridium acetobutylicum ATCC 824
Acetyl-CoA acetyltransferaseEC 2.3.1.9; Acetoacetyl-CoA thiolaseEscherichia coli K-12
Beta-ketothiolase BktBEC 2.3.1.16; EC 2.3.1.9; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferaseCupriavidus necator H16

Compounds (11)

CompoundDescription
hydronium ion
NADH
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
iodoacetamideAn alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Coenzyme A
acetoacetyl CoA
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.