zuclomiphene and Breast-Neoplasms

zuclomiphene has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for zuclomiphene and Breast-Neoplasms

Article	Year
Ellipticine derivatives with an affinity to the estrogen receptor, an approach to develop intercalating drugs with a specific effect on the hormone-dependent breast cancer. Journal of medicinal chemistry, 1985, Volume: 28, Issue:6 In order to obtain breast tumor directed agents, we have prepared mixed compounds using estradiol or (E)-clomiphene as specific vectors of the breast tissue and a DNA intercalator from the ellipticine series as the cytotoxic agent. Among the newly synthesized ellipticine derivatives, only the 2-[3-aza-5-(3,17 beta-dihydroxy-1,3,5-estratrien-17 alpha-yl)-4-oxopentamethylene]ellipticinium bromide shows the desired properties, DNA intercalation and affinity for estrogen receptor. Competition experiments with estradiol on the hormone-dependent human MCF-7 breast cancer cell line demonstrate that a transport by the estrogen receptor system is not involved in the antitumor activity of derivative 24. Topics: Alkaloids; Animals; Breast Neoplasms; Cattle; Cell Line; DNA; Ellipticines; Female; Humans; In Vitro Techniques; Intercalating Agents; Leukemia L1210; Neoplasms, Hormone-Dependent; Receptors, Estrogen	1985

Article

Year

Ellipticine derivatives with an affinity to the estrogen receptor, an approach to develop intercalating drugs with a specific effect on the hormone-dependent breast cancer.

Journal of medicinal chemistry, 1985, Volume: 28, Issue:6

In order to obtain breast tumor directed agents, we have prepared mixed compounds using estradiol or (E)-clomiphene as specific vectors of the breast tissue and a DNA intercalator from the ellipticine series as the cytotoxic agent. Among the newly synthesized ellipticine derivatives, only the 2-[3-aza-5-(3,17 beta-dihydroxy-1,3,5-estratrien-17 alpha-yl)-4-oxopentamethylene]ellipticinium bromide shows the desired properties, DNA intercalation and affinity for estrogen receptor. Competition experiments with estradiol on the hormone-dependent human MCF-7 breast cancer cell line demonstrate that a transport by the estrogen receptor system is not involved in the antitumor activity of derivative 24.

Topics: Alkaloids; Animals; Breast Neoplasms; Cattle; Cell Line; DNA; Ellipticines; Female; Humans; In Vitro Techniques; Intercalating Agents; Leukemia L1210; Neoplasms, Hormone-Dependent; Receptors, Estrogen

1985