zstk474 and Neoplasm-Metastasis

zstk474 has been researched along with Neoplasm-Metastasis* in 1 studies

Other Studies

1 other study(ies) available for zstk474 and Neoplasm-Metastasis

ArticleYear
Synthesis and anti-metastatic effects of pregn-17(20)-en-3-amine derivatives.
    European journal of medicinal chemistry, 2016, Nov-29, Volume: 124

    Novel pregn-17(20)-en-3-amine derivatives were synthesized and their anti-metastatic effects were evaluated in human breast cancer cells using chemotaxis assay. Compared with positive control LY294002, a PI3K inhibitor, derivatives 5a, 19a, 20a, 19g, 20f, 5c, 12e and 12f exhibited significant inhibitory effects against cancer cell migration induced by chemokine epidermal growth factor (EGF). Especially, the IC

    Topics: Amines; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Humans; Inhibitory Concentration 50; Integrin beta1; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship

2016