zstk474 and Neoplasm-Metastasis

zstk474 has been researched along with Neoplasm-Metastasis* in 1 studies

Other Studies

1 other study(ies) available for zstk474 and Neoplasm-Metastasis

Article	Year
Synthesis and anti-metastatic effects of pregn-17(20)-en-3-amine derivatives. European journal of medicinal chemistry, 2016, Nov-29, Volume: 124 Novel pregn-17(20)-en-3-amine derivatives were synthesized and their anti-metastatic effects were evaluated in human breast cancer cells using chemotaxis assay. Compared with positive control LY294002, a PI3K inhibitor, derivatives 5a, 19a, 20a, 19g, 20f, 5c, 12e and 12f exhibited significant inhibitory effects against cancer cell migration induced by chemokine epidermal growth factor (EGF). Especially, the IC Topics: Amines; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Humans; Inhibitory Concentration 50; Integrin beta1; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship	2016

Article

Year

Synthesis and anti-metastatic effects of pregn-17(20)-en-3-amine derivatives.

European journal of medicinal chemistry, 2016, Nov-29, Volume: 124

Novel pregn-17(20)-en-3-amine derivatives were synthesized and their anti-metastatic effects were evaluated in human breast cancer cells using chemotaxis assay. Compared with positive control LY294002, a PI3K inhibitor, derivatives 5a, 19a, 20a, 19g, 20f, 5c, 12e and 12f exhibited significant inhibitory effects against cancer cell migration induced by chemokine epidermal growth factor (EGF). Especially, the IC

Topics: Amines; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Humans; Inhibitory Concentration 50; Integrin beta1; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship

2016