zotepine has been researched along with Neuroleptic Malignant Syndrome in 3 studies
zotepine: structure
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 39-year-old man with schizophrenia developed severe catatonia, hyperthermia, muscle rigidity, tachycardia, leukocytosis, and elevated muscle enzyme levels while receiving zotepine therapy." | 7.73 | Zotepine-induced catatonia as a precursor in the progression to neuroleptic malignant syndrome. ( Chen, CC; Tsai, JH; Yang, MJ; Yang, P; Yen, JY, 2005) |
| "A 39-year-old man with schizophrenia developed severe catatonia, hyperthermia, muscle rigidity, tachycardia, leukocytosis, and elevated muscle enzyme levels while receiving zotepine therapy." | 3.73 | Zotepine-induced catatonia as a precursor in the progression to neuroleptic malignant syndrome. ( Chen, CC; Tsai, JH; Yang, MJ; Yang, P; Yen, JY, 2005) |
| "In a schizophrenic patient, hypothermia was caused by combined treatment with zotepine, biperiden, and fluphenazine, although combined treatment with zotepine and biperiden had caused no side effects." | 3.67 | Hypothermia caused by antipsychotic drugs in a schizophrenic patient. ( Hashimoto, H; Kamimura, H; Nakajima, T; Nakao, J; Noto, T; Okamoto, K; Sugae, S, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hsu, WC | 1 |
| Lin, ST | 1 |
| Chen, CC | 2 |
| Tsang, HY | 1 |
| Huang, MF | 1 |
| Tsai, JH | 1 |
| Yang, P | 1 |
| Yen, JY | 1 |
| Yang, MJ | 1 |
| Noto, T | 1 |
| Hashimoto, H | 1 |
| Sugae, S | 1 |
| Okamoto, K | 1 |
| Nakao, J | 1 |
| Kamimura, H | 1 |
| Nakajima, T | 1 |
3 other studies available for zotepine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
A self-limiting case of atypical neuroleptic malignant syndrome associated with zotepine.
Topics: Antipsychotic Agents; Dibenzothiepins; Humans; Male; Middle Aged; Neuroleptic Malignant Syndrome; Sc | 2011 |
Zotepine-induced catatonia as a precursor in the progression to neuroleptic malignant syndrome.
Topics: Antipsychotic Agents; Blood Chemical Analysis; Catatonia; Dibenzothiepins; Disease Progression; Feve | 2005 |
Hypothermia caused by antipsychotic drugs in a schizophrenic patient.
Topics: Adult; Biperiden; Dibenzothiepins; Drug Therapy, Combination; Fluphenazine; Humans; Hypothermia; Mal | 1987 |