zopolrestat has been researched along with Myocardial Ischemia in 6 studies
zopolrestat: structure given in first source
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated whether aldose reductase (AR) inhibition with zopolrestat, either alone or in combination with an adenosine A(3)-receptor agonist (CB-MECA), reduced myocardial ischemic injury in rabbit hearts subjected to 30 min of regional ischemia and 120 min of reperfusion." | 1.31 | Aldose reductase inhibition alone or combined with an adenosine A(3) agonist reduces ischemic myocardial injury. ( Ellery, CA; Knight, DR; MacAndrew, JT; Magee, WP; Oates, PJ; Smith, AH; Tracey, WR, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, WH | 1 |
| Kravtsov, GM | 1 |
| Sauert, M | 1 |
| Tong, XY | 1 |
| Hou, XY | 1 |
| Wong, TM | 1 |
| Chung, SK | 1 |
| Man Chung, SS | 1 |
| Ramasamy, R | 4 |
| Oates, PJ | 4 |
| Schaefer, S | 3 |
| Trueblood, N | 1 |
| Liu, H | 1 |
| Tracey, WR | 1 |
| Magee, WP | 1 |
| Ellery, CA | 1 |
| MacAndrew, JT | 1 |
| Smith, AH | 1 |
| Knight, DR | 1 |
| Hwang, YC | 1 |
| Sato, S | 1 |
| Tsai, JY | 1 |
| Yan, S | 1 |
| Bakr, S | 1 |
| Zhang, H | 1 |
6 other studies available for zopolrestat and Myocardial Ischemia
| Article | Year |
|---|---|
Polyol pathway impairs the function of SERCA and RyR in ischemic-reperfused rat hearts by increasing oxidative modifications of these proteins.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Heart; L-Iditol 2-Dehydrogenase; Male; Myocardial Contr | 2010 |
Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Benzothiazoles; Blood Glucose; Diabetes Mellitu | 1997 |
Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Cytosol; Diabetes Mellitus, Type 1; Enzyme Inhibitors; | 1998 |
Attenuation of ischemia induced increases in sodium and calcium by the aldose reductase inhibitor zopolrestat.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Benzothiazoles; Calcium; Diabetes Mellitus, Type | 1999 |
Aldose reductase inhibition alone or combined with an adenosine A(3) agonist reduces ischemic myocardial injury.
Topics: Adenosine; Aldehyde Reductase; Animals; Benzothiazoles; Dose-Response Relationship, Drug; Enzyme Inh | 2000 |
Aldose reductase activation is a key component of myocardial response to ischemia.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Enzyme Inhibitors; Glucose; Myocardial Ischemia; Myocar | 2002 |