zopiclone has been researched along with Substance Withdrawal Syndrome in 41 studies
zopiclone: S(+)-enantiomer of racemic zopiclone; azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; was term of zopiclone 2004-2007
zopiclone : A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zopiclone was resumed at a lower dose and delirium resolved completely." | 5.33 | Zopiclone withdrawal: an unusual cause of delirium in the elderly. ( Chiu, PK; Chu, LW; Wong, CP, 2005) |
| "A double-blind study comparing zopiclone and triazolam, in 48 healthy, chronic insomniacs, was undertaken in two centers to compare the hypnotic and withdrawal effects of both compounds." | 5.06 | A comparison of the efficacy, safety and withdrawal effects of zopiclone and triazolam in the treatment of insomnia. ( Bourgouin, J; Fleming, JA; Mayes, C; McClure, DJ; Phillips, R, 1990) |
| " Only few controlled studies have characterized the effect of discontinuation of their chronic use on sleep and quality of life." | 2.90 | Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia. ( Kivelä, SL; Lähteenmäki, R; Neuvonen, PJ; Partinen, M; Puustinen, J; Räihä, I; Vahlberg, T, 2019) |
| "92 outpatients (≥55 years) with primary insomnia, long-term BZDA use as hypnotics (mean duration of BZDA use 9." | 2.87 | Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study. ( Aarnio, P; Kivelä, SL; Lähteenmäki, R; Neuvonen, PJ; Nurminen, J; Partinen, M; Puustinen, J; Räihä, I; Vahlberg, T, 2018) |
| " As impaired muscle strength and balance are risk factors for falls, we examined the effects of hypnotic withdrawal on handgrip strength and balance in older adult outpatients during and after long-term use of temazepam, zopiclone and zolpidem (here collectively referred to as "benzodiazepines")." | 2.79 | Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics. ( Kivelä, SL; Lähteenmäki, R; Lyles, A; Neuvonen, PJ; Nurminen, J; Partinen, M; Puustinen, J; Räihä, I; Vahlberg, T, 2014) |
| "Rebound effects after withdrawal from hypnotics are believed to trigger their chronic use and to enhance the risk of tolerance and dependence." | 2.70 | A double-blind, randomized and placebo-controlled study on the polysomnographic withdrawal effects of zopiclone, zolpidem and triazolam in healthy subjects. ( Backhaus, J; Berger, M; Feige, B; Hohagen, F; Hornyak, M; Riemann, D; Voderholzer, U, 2001) |
| "Twenty-four volunteers (19 women and five men) with insomnia and a history of chronic use of benzodiazepine hypnotics participated in a randomized, double blind, controlled clinical trial." | 2.69 | The effects of substituting zopiclone in withdrawal from chronic use of benzodiazepine hypnotics. ( Hacohen, D; Herer, P; Lavie, P; Pat-Horenczyk, R, 1998) |
| " In this double-blind study in geriatric patients, drugs were administered during 3 weeks and the therapeutic effects of zopiclone at optimal dosage (5 or 7." | 2.67 | Efficacy and safety of zopiclone and triazolam in the treatment of geriatric insomniacs. ( Bourgouin, J; Elie, R; Frenay, M; Le Morvan, P, 1990) |
| "Zopiclone was associated with feelings of being troubled, tense, antagonistic and bored whereas temazepam produced drowsiness, clumsiness, dreaminess and sadness." | 2.66 | Subjective effects during administration and on discontinuation of zopiclone and temazepam in normal subjects. ( Frcka, G; Lader, M, 1987) |
| "Former substance abusers and psychiatric patients appear to be at greatest risk." | 2.45 | Comparative tolerability of newer agents for insomnia. ( Zammit, G, 2009) |
| " This review of relevant literature has revealed a lack of documentation on the adverse effects of zopiclone." | 2.40 | [Adverse effects of zopiclone]. ( Bramness, JG; Olsen, H, 1998) |
| "Zopiclone-treated patients reported themselves to be less impaired by daytime sedation than patients treated with the medium- and long-acting hypnosedatives flurazepam, nitrazepam and flunitrazepam." | 2.40 | A comparative assessment of the risks and benefits of zopiclone: a review of 15 years' clinical experience. ( Hajak, G, 1999) |
| "The aim of this study was to assess the effect of withdrawal from the long-term use of temazepam, zopiclone or zolpidem as hypnotics drugs (here referred to as BZD) on cognitive performance." | 1.40 | Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults. ( Kivelä, SL; Lähteenmäki, R; Lyles, A; Neuvonen, PJ; Partinen, M; Polo-Kantola, P; Puustinen, J; Räihä, I; Salo, P; Vahlberg, T, 2014) |
| "Zopiclone was resumed at a lower dose and delirium resolved completely." | 1.33 | Zopiclone withdrawal: an unusual cause of delirium in the elderly. ( Chiu, PK; Chu, LW; Wong, CP, 2005) |
| "While one patient had a polysubstance abuse there was no evidence for an abuse history in the other patient." | 1.30 | [Dependency of non-benzodiazepine hypnotics. Two case reports]. ( Antonijevic, IA; Sonntag, A; Steiger, A; Ströhle, A, 1999) |
| "Furthermore, the patient suffered from convulsion on two occasions following abrupt withdrawal of zopiclone." | 1.28 | Misuse of zopiclone and convulsions during withdrawal. ( Aranko, K; Henriksson, M; Hublin, C; Seppäläinen, AM, 1991) |
| "Eleven chronic insomniacs participated in the study where both EEG sleep recordings and a subjective rating scale were used to evaluate drug effects." | 1.28 | Long term efficacy and withdrawal of zopiclone: a sleep laboratory study. ( le Morvan, P; Pecknold, J; Wilson, R, 1990) |
| "Zopiclone was self-administered by rhesus monkeys relatively frequently by the intravenous route; the infrequent intragastric rate was similar to or slightly higher than with diazepam." | 1.26 | Dependence potential of zopiclone studied in monkeys. ( Yanagita, T, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (19.51) | 18.7374 |
| 1990's | 18 (43.90) | 18.2507 |
| 2000's | 8 (19.51) | 29.6817 |
| 2010's | 7 (17.07) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marsden, J | 1 |
| White, M | 1 |
| Annand, F | 1 |
| Burkinshaw, P | 1 |
| Carville, S | 1 |
| Eastwood, B | 1 |
| Kelleher, M | 1 |
| Knight, J | 1 |
| O'Connor, R | 1 |
| Tran, A | 1 |
| Willey, P | 1 |
| Greaves, F | 1 |
| Taylor, S | 1 |
| Puustinen, J | 4 |
| Lähteenmäki, R | 4 |
| Nurminen, J | 2 |
| Vahlberg, T | 4 |
| Aarnio, P | 1 |
| Partinen, M | 4 |
| Räihä, I | 4 |
| Neuvonen, PJ | 4 |
| Kivelä, SL | 4 |
| Hahn, M | 1 |
| Roll, SC | 1 |
| Polo-Kantola, P | 1 |
| Salo, P | 1 |
| Lyles, A | 2 |
| Zammit, G | 1 |
| Kristensen, Ø | 1 |
| Pasareanu, AR | 1 |
| McMahon, LR | 1 |
| Jerussi, TP | 1 |
| France, CP | 1 |
| Kuntze, MF | 1 |
| Bullinger, AH | 1 |
| Mueller-Spahn, F | 1 |
| Wong, CP | 1 |
| Chiu, PK | 1 |
| Chu, LW | 1 |
| Flynn, A | 1 |
| Cox, D | 1 |
| Belleville, G | 1 |
| Morin, CM | 1 |
| Siriwardena, AN | 1 |
| Qureshi, MZ | 1 |
| Dyas, JV | 1 |
| Middleton, H | 1 |
| Orner, R | 1 |
| Bechelli, LP | 1 |
| Navas, F | 1 |
| Pierangelo, SA | 1 |
| Wickstrøm, E | 2 |
| Barbo, SE | 2 |
| Dreyfus, JF | 2 |
| Jerkø, D | 2 |
| Kleiven, R | 2 |
| Slåttbrekk, R | 2 |
| Stray Tønnesen, JN | 2 |
| Yanagita, T | 2 |
| Kato, S | 1 |
| Dorian, P | 2 |
| Sellers, EM | 2 |
| Kaplan, H | 2 |
| Hamilton, C | 2 |
| Shapiro, CM | 1 |
| MacFarlane, JG | 1 |
| MacLean, AW | 1 |
| Lemoine, P | 1 |
| Ohayon, MM | 1 |
| Jones, IR | 1 |
| Sullivan, G | 1 |
| Bramness, JG | 1 |
| Olsen, H | 1 |
| Pat-Horenczyk, R | 1 |
| Hacohen, D | 1 |
| Herer, P | 1 |
| Lavie, P | 1 |
| Ströhle, A | 1 |
| Antonijevic, IA | 1 |
| Steiger, A | 1 |
| Sonntag, A | 1 |
| Feige, B | 2 |
| Voderholzer, U | 2 |
| Riemann, D | 2 |
| Hohagen, F | 2 |
| Berger, M | 2 |
| Hajak, G | 1 |
| Harter, C | 1 |
| Piffl-Boniolo, E | 1 |
| Rave-Schwank, M | 1 |
| Hornyak, M | 1 |
| Backhaus, J | 1 |
| Kajaste, S | 1 |
| Palomäki, H | 1 |
| Aranko, K | 1 |
| Henriksson, M | 1 |
| Hublin, C | 1 |
| Seppäläinen, AM | 1 |
| Kelly, F | 1 |
| O'Grady, J | 1 |
| Champey, Y | 1 |
| Pecknold, J | 1 |
| Wilson, R | 1 |
| le Morvan, P | 2 |
| Fleming, JA | 1 |
| McClure, DJ | 1 |
| Mayes, C | 1 |
| Phillips, R | 1 |
| Bourgouin, J | 2 |
| Elie, R | 1 |
| Frenay, M | 1 |
| Mouret, J | 1 |
| Ruel, D | 1 |
| Maillard, F | 1 |
| Bianchi, M | 2 |
| Musch, B | 1 |
| Lader, M | 1 |
| Frcka, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of a Coordinated, Community-Based Medication Management Model for Home-Dwelling Aged in Primary Care[NCT02545257] | 191 participants (Actual) | Interventional | 2015-09-30 | Completed | |||
| Addressing Nocturnal Sleep/Wake Effects on Risk of Suicide in Older Adults (ANSWERS-OA): A Pilot, Open-Label, Randomized Controlled Trial of Digital Cognitive Behavioral Therapy for Insomnia[NCT04986007] | 70 participants (Anticipated) | Interventional | 2021-09-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for zopiclone and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Medicines associated with dependence or withdrawal: a mixed-methods public health review and national database study in England.
Topics: Acetamides; Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Antidepressive Agents; Azabicyc | 2019 |
Comparative tolerability of newer agents for insomnia.
Topics: Azabicyclo Compounds; Clinical Trials as Topic; Drug Interactions; Humans; Hypnotics and Sedatives; | 2009 |
[Adverse effects of zopiclone].
Topics: Azabicyclo Compounds; Drug Tolerance; Humans; Hypnotics and Sedatives; Piperazines; Substance Withdr | 1998 |
A comparative assessment of the risks and benefits of zopiclone: a review of 15 years' clinical experience.
Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Clinical Trials as Topic; Humans; Hypnotics and Seda | 1999 |
[Advantages and disadvantages of sleeping pills].
Topics: Azabicyclo Compounds; Benzodiazepines; Humans; Hypnotics and Sedatives; Piperazines; Sleep Initiatio | 1991 |
Zopiclone: another carriage on the tranquilliser train.
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Sleep Initiation and Maintenance | 1990 |
17 trials available for zopiclone and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study.
Topics: Aged; Azabicyclo Compounds; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypnotics and Se | 2018 |
Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia.
Topics: Aged; Aged, 80 and over; Azabicyclo Compounds; Double-Blind Method; Female; Humans; Hypnotics and Se | 2019 |
Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics.
Topics: Aged; Aged, 80 and over; Azabicyclo Compounds; Female; Follow-Up Studies; Hand Strength; Humans; Hyp | 2014 |
Hypnotic discontinuation in chronic insomnia: impact of psychological distress, readiness to change, and self-efficacy.
Topics: Acetamides; Adaptation, Psychological; Adult; Aged; Anxiety; Attitude to Health; Azabicyclo Compound | 2008 |
A comparative study of zopiclone and flunitrazepam in insomniacs seen by general practitioners.
Topics: Adolescent; Adult; Azabicyclo Compounds; Clinical Trials as Topic; Double-Blind Method; Family Pract | 1983 |
Evaluation of zopiclone physical dependence liability in normal volunteers.
Topics: Adult; Anxiety; Azabicyclo Compounds; Double-Blind Method; Hemodynamics; Humans; Hypnotics and Sedat | 1983 |
A comparative study of zopiclone and flunitrazepam in insomniacs seen by general practitioners.
Topics: Adolescent; Adult; Azabicyclo Compounds; Clinical Trials as Topic; Double-Blind Method; Family Pract | 1982 |
Evaluation of zopiclone physical dependence liability in normal volunteers.
Topics: Adult; Anxiety; Azabicyclo Compounds; Double-Blind Method; Electroencephalography; Hemodynamics; Hum | 1982 |
Alleviating sleep-related discontinuance symptoms associated with benzodiazepine withdrawal: a new approach.
Topics: Adult; Azabicyclo Compounds; Benzodiazepines; Female; Humans; Hypnotics and Sedatives; Male; Middle | 1993 |
Is hypnotic withdrawal facilitated by the transitory use of a substitute drug?
Topics: Adolescent; Adult; Aged; Azabicyclo Compounds; Female; Humans; Hypnotics and Sedatives; Male; Middle | 1997 |
The effects of substituting zopiclone in withdrawal from chronic use of benzodiazepine hypnotics.
Topics: Adult; Anti-Anxiety Agents; Azabicyclo Compounds; Double-Blind Method; Female; Flunitrazepam; Follow | 1998 |
Independent sleep EEG slow-wave and spindle band dynamics associated with 4 weeks of continuous application of short-half-life hypnotics in healthy subjects.
Topics: Adult; Azabicyclo Compounds; Double-Blind Method; Electroencephalography; Humans; Hypnotics and Seda | 1999 |
A double-blind, randomized and placebo-controlled study on the polysomnographic withdrawal effects of zopiclone, zolpidem and triazolam in healthy subjects.
Topics: Adult; Azabicyclo Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalo | 2001 |
A comparison of the efficacy, safety and withdrawal effects of zopiclone and triazolam in the treatment of insomnia.
Topics: Adolescent; Adult; Azabicyclo Compounds; Double-Blind Method; Female; Humans; Hypnotics and Sedative | 1990 |
Efficacy and safety of zopiclone and triazolam in the treatment of geriatric insomniacs.
Topics: Aged; Aged, 80 and over; Arousal; Azabicyclo Compounds; Dose-Response Relationship, Drug; Double-Bli | 1990 |
Zopiclone versus triazolam in insomniac geriatric patients: a specific increase in delta sleep with zopiclone.
Topics: Aged; Aged, 80 and over; Arousal; Azabicyclo Compounds; Delta Rhythm; Double-Blind Method; Electroen | 1990 |
Subjective effects during administration and on discontinuation of zopiclone and temazepam in normal subjects.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Arousal; Azabicyclo Compounds; Female; Humans; Hypnotics and Se | 1987 |
18 other studies available for zopiclone and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
A patient with acute mania after discontinuation of lithium.
Topics: Azabicyclo Compounds; Bipolar Disorder; Drug Interactions; Drug Substitution; Drug Therapy, Combinat | 2016 |
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M | 2014 |
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M | 2014 |
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M | 2014 |
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M | 2014 |
[Zopiclone and convulsions].
Topics: Adult; Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Male; Piperazines; Seizures; Substance | 2010 |
Stereoselective discriminative stimulus effects of zopiclone in rhesus monkeys.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Diazepam; Discrimination L | 2003 |
Excessive use of zopiclone: a case report.
Topics: Aged; Azabicyclo Compounds; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Ove | 2002 |
Zopiclone withdrawal: an unusual cause of delirium in the elderly.
Topics: Aged; Azabicyclo Compounds; Delirium; Female; Humans; Hypnotics and Sedatives; Piperazines; Substanc | 2005 |
Dependence on zopiclone.
Topics: Aged; Azabicyclo Compounds; Female; Humans; Hypnotics and Sedatives; Piperazines; Seizures; Sleep In | 2006 |
Magic bullets for insomnia? Patients' use and experiences of newer (Z drugs) versus older (benzodiazepine) hypnotics for sleep problems in primary care.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Attitude to Health; Azabicyclo Compounds; Be | 2008 |
Comparison of the reinforcing properties of zopiclone and triazolam in former alcoholics.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Azabicyclo Compounds; Capsules; Double-Blind Method; Electro | 1982 |
Dependence studies on zopiclone.
Topics: Animals; Azabicyclo Compounds; Barbiturates; Behavior, Animal; Diazepam; Humans; Hypnotics and Sedat | 1983 |
Dependence potential of zopiclone studied in monkeys.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Barbital; Diazepam; Female; Humans; Hypnotics a | 1982 |
Physical dependence on zopiclone: case reports.
Topics: Adult; Azabicyclo Compounds; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Piperazines | 1998 |
[Dependency of non-benzodiazepine hypnotics. Two case reports].
Topics: Adult; Azabicyclo Compounds; Benzodiazepines; Depression; Humans; Hypnotics and Sedatives; Male; Mid | 1999 |
[Development of drug withdrawal delirium after dependence on zolpidem and zoplicone].
Topics: Anxiety Disorders; Azabicyclo Compounds; Drug Therapy, Combination; Female; Humans; Hypnotics and Se | 1999 |
Misuse of zopiclone and convulsions during withdrawal.
Topics: Adult; Azabicyclo Compounds; Depressive Disorder; Humans; Hypnotics and Sedatives; Male; Piperazines | 1991 |
Zopiclone.
Topics: Azabicyclo Compounds; Humans; Piperazines; Product Surveillance, Postmarketing; Sleep Initiation and | 1990 |
Long term efficacy and withdrawal of zopiclone: a sleep laboratory study.
Topics: Adult; Arousal; Azabicyclo Compounds; Electroencephalography; Female; Humans; Hypnotics and Sedative | 1990 |
Zopiclone discontinuation: review of 25 studies assessing withdrawal and rebound phenomena.
Topics: Azabicyclo Compounds; Dose-Response Relationship, Drug; Electroencephalography; Female; Humans; Hypn | 1990 |