zopiclone has been researched along with Chemical Dependence in 69 studies
zopiclone: S(+)-enantiomer of racemic zopiclone; azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; was term of zopiclone 2004-2007
zopiclone : A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The maximal dosage was 8 capsules per day (2." | 2.65 | Studies on the dependence-inducing potential of zopiclone and triazolam. ( Boissl, K; Delmotte, M; Dreyfus, JF, 1983) |
| " The maximal dosage was 8 capsules per day (2." | 2.65 | Studies on the dependence-inducing potential of zopiclone and triazolam. ( Boissl, K; Delmotte, M; Dreyfus, JF, 1982) |
| "Former substance abusers and psychiatric patients appear to be at greatest risk." | 2.45 | Comparative tolerability of newer agents for insomnia. ( Zammit, G, 2009) |
| " This review of relevant literature has revealed a lack of documentation on the adverse effects of zopiclone." | 2.40 | [Adverse effects of zopiclone]. ( Bramness, JG; Olsen, H, 1998) |
| "Zopiclone-treated patients reported themselves to be less impaired by daytime sedation than patients treated with the medium- and long-acting hypnosedatives flurazepam, nitrazepam and flunitrazepam." | 2.40 | A comparative assessment of the risks and benefits of zopiclone: a review of 15 years' clinical experience. ( Hajak, G, 1999) |
| "Comorbid psychiatric illness was diagnosed in 67 patients (39." | 1.46 | Benzodiazepine and "Z-Drug" Dependence: Data From a Tertiary Care Center. ( Benegal, V; Bokka, S; Chand, P; Kandasamy, A; Murthy, P; Shukla, L; Shukla, T, 2017) |
| "Psychotic disorders are the most frequent psychiatric diagnosis associated with cough mixture abuse." | 1.38 | Clinical characteristics of cough mixture abusers referred to three substance abuse clinics in Hong Kong: a retrospective study. ( Chan, F; Liang, HJ; Mak, SC; Tang, AK; Tang, WK; Ungvari, GS, 2012) |
| "Zopiclone has the potential for being an agent of abuse and addiction." | 1.34 | Zopiclone: is it a pharmacologic agent for abuse? ( Cimolai, N, 2007) |
| "Zopiclone dependence has repeatedly been reported in patients with pre-existing substance-related addictions, and in patients with other psychiatric disorders." | 1.31 | [A case of primary zopiclone dependence]. ( Brüne, M; Kahlert, I, 2001) |
| "While one patient had a polysubstance abuse there was no evidence for an abuse history in the other patient." | 1.30 | [Dependency of non-benzodiazepine hypnotics. Two case reports]. ( Antonijevic, IA; Sonntag, A; Steiger, A; Ströhle, A, 1999) |
| "Furthermore, the patient suffered from convulsion on two occasions following abrupt withdrawal of zopiclone." | 1.28 | Misuse of zopiclone and convulsions during withdrawal. ( Aranko, K; Henriksson, M; Hublin, C; Seppäläinen, AM, 1991) |
| "Zopiclone was self-administered by rhesus monkeys relatively frequently by the intravenous route; the infrequent intragastric rate was similar to or slightly higher than with diazepam." | 1.27 | Dependence potential of zopiclone studied in monkeys. ( Yanagita, T, 1983) |
| "Zopiclone was self-administered by rhesus monkeys relatively frequently by the intravenous route; the infrequent intragastric rate was similar to or slightly higher than with diazepam." | 1.26 | Dependence potential of zopiclone studied in monkeys. ( Yanagita, T, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (15.94) | 18.7374 |
| 1990's | 24 (34.78) | 18.2507 |
| 2000's | 19 (27.54) | 29.6817 |
| 2010's | 14 (20.29) | 24.3611 |
| 2020's | 1 (1.45) | 2.80 |
| Authors | Studies |
|---|---|
| Marsden, J | 1 |
| White, M | 1 |
| Annand, F | 1 |
| Burkinshaw, P | 1 |
| Carville, S | 1 |
| Eastwood, B | 1 |
| Kelleher, M | 1 |
| Knight, J | 1 |
| O'Connor, R | 1 |
| Tran, A | 1 |
| Willey, P | 1 |
| Greaves, F | 1 |
| Taylor, S | 1 |
| Victorri-Vigneau, C | 3 |
| Laforgue, EJ | 1 |
| Grall-Bronnec, M | 2 |
| Guillou-Landreat, M | 1 |
| Rousselet, M | 2 |
| Guerlais, M | 1 |
| Feuillet, F | 3 |
| Jolliet, P | 3 |
| Gerardin, M | 1 |
| Hardouin, JB | 1 |
| Schifano, F | 1 |
| Chiappini, S | 1 |
| Corkery, JM | 1 |
| Guirguis, A | 1 |
| Wainstein, L | 1 |
| Pivette, J | 1 |
| Chaslerie, A | 1 |
| Sébille, V | 1 |
| Schulz, M | 1 |
| Hoffmann, F | 3 |
| Schmiemann, G | 1 |
| Windt, R | 1 |
| Jonsson, B | 1 |
| Backman, E | 1 |
| Salmonson, H | 1 |
| Höjer, J | 1 |
| Curreen, M | 1 |
| Lidmila, J | 1 |
| Yen, CF | 1 |
| Yen, CN | 1 |
| Ko, CH | 1 |
| Hwang, TJ | 1 |
| Chen, CS | 1 |
| Chen, TT | 1 |
| Su, PW | 1 |
| Chen, ST | 1 |
| Lin, JJ | 1 |
| Stern, F | 1 |
| Shukla, L | 1 |
| Bokka, S | 1 |
| Shukla, T | 1 |
| Kandasamy, A | 1 |
| Chand, P | 1 |
| Benegal, V | 1 |
| Murthy, P | 1 |
| Smink, BE | 1 |
| Lusthof, KJ | 1 |
| de Gier, JJ | 1 |
| Uges, DR | 1 |
| Egberts, AC | 1 |
| Gustavsen, I | 1 |
| Al-Sammurraie, M | 1 |
| Mørland, J | 2 |
| Bramness, JG | 4 |
| Zammit, G | 1 |
| Alderman, CP | 1 |
| Gilbert, AL | 1 |
| Hies, M | 1 |
| Glaeske, G | 2 |
| Jones, AW | 1 |
| Holmgren, A | 1 |
| Tang, AK | 1 |
| Tang, WK | 1 |
| Liang, HJ | 1 |
| Chan, F | 1 |
| Mak, SC | 1 |
| Ungvari, GS | 1 |
| Kuntze, MF | 1 |
| Bullinger, AH | 1 |
| Mueller-Spahn, F | 1 |
| Hajak, G | 3 |
| Müller, WE | 1 |
| Wittchen, HU | 1 |
| Pittrow, D | 1 |
| Kirch, W | 1 |
| Matsumoto, C | 1 |
| Nakamura, J | 1 |
| Haasen, C | 1 |
| Mueller-Thomsen, T | 1 |
| Fink, T | 1 |
| Bussopulos, A | 1 |
| Reimer, J | 1 |
| Nutt, DJ | 1 |
| Alford, C | 1 |
| Verster, J | 1 |
| Lader, M | 2 |
| Mellingsaeter, TC | 1 |
| Slørdal, L | 1 |
| Bannan, N | 1 |
| Rooney, S | 2 |
| O'connor, J | 1 |
| Pfannkuche, M | 1 |
| Cimolai, N | 1 |
| Fleming, JA | 1 |
| Samuels, CH | 1 |
| MacFarlane, J | 1 |
| Morehouse, R | 1 |
| Boissl, K | 2 |
| Dreyfus, JF | 2 |
| Delmotte, M | 2 |
| Bechelli, LP | 1 |
| Navas, F | 1 |
| Pierangelo, SA | 1 |
| Yanagita, T | 3 |
| Kato, S | 1 |
| Dorian, P | 2 |
| Sellers, EM | 2 |
| Kaplan, H | 2 |
| Hamilton, C | 2 |
| Luty, S | 1 |
| Sellman, D | 1 |
| Rüther, E | 1 |
| Sikdar, S | 2 |
| Ruben, SM | 1 |
| Clee, WB | 1 |
| McBride, AJ | 1 |
| Sullivan, G | 2 |
| Pallavicini, J | 1 |
| Acevedo, X | 1 |
| Jones, IR | 1 |
| Olsen, H | 1 |
| Ayonrinde, O | 1 |
| Sampson, E | 1 |
| O'Conner, JJ | 1 |
| Irgens, A | 1 |
| Ströhle, A | 1 |
| Antonijevic, IA | 1 |
| Steiger, A | 1 |
| Sonntag, A | 1 |
| Skurtveit, S | 1 |
| Harter, C | 1 |
| Piffl-Boniolo, E | 1 |
| Rave-Schwank, M | 1 |
| Kahlert, I | 1 |
| Brüne, M | 1 |
| Kajaste, S | 1 |
| Palomäki, H | 1 |
| Aranko, K | 1 |
| Henriksson, M | 1 |
| Hublin, C | 1 |
| Seppäläinen, AM | 1 |
| Kelly, F | 1 |
| O'Grady, J | 1 |
| Champey, Y | 1 |
| Sutherland, JC | 1 |
| Piot, O | 1 |
| Betschart, J | 1 |
| Stutzmann, JM | 1 |
| Blanchard, JC | 1 |
| Thompson, SH | 1 |
| Anderson, A | 1 |
| Crawford, RJ | 1 |
| Goa, KL | 1 |
| Heel, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of Problematic Use of Benzodiazepines and Z Drugs in the Elderly in France: a Public Health Issue[NCT01920581] | 1,100 participants (Anticipated) | Observational | 2012-02-29 | Recruiting | |||
| Clonidine is Better Than Zopiclone for Insomnia Treatment in Chronic Pain Patients[NCT05277038] | 150 participants (Actual) | Observational [Patient Registry] | 2022-03-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for zopiclone and Chemical Dependence
| Article | Year |
|---|---|
Medicines associated with dependence or withdrawal: a mixed-methods public health review and national database study in England.
Topics: Acetamides; Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Antidepressive Agents; Azabicyc | 2019 |
Zopiclone: Is there cause for concern in addiction services and general practice?
Topics: Accidents, Traffic; Automobile Driving; Azabicyclo Compounds; General Practice; Humans; Hypnotics an | 2014 |
Comparative tolerability of newer agents for insomnia.
Topics: Azabicyclo Compounds; Clinical Trials as Topic; Drug Interactions; Humans; Hypnotics and Sedatives; | 2009 |
Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data.
Topics: Adult; Aged; Azabicyclo Compounds; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Piper | 2003 |
[Other sedatives and hypnotics-related disorders].
Topics: Antidepressive Agents; Antipsychotic Agents; Azabicyclo Compounds; Bromisovalum; Humans; Hypnotics a | 2003 |
[New non-benzodiazepine hypnotics. Progress in therapy of sleep disorders?].
Topics: Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepines; Humans; Hypnotics and Sedatives; Piperaz | 1995 |
Zopiclone: is there any dependence and abuse potential?
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Substance-Related Disorders | 1997 |
[Adverse effects of zopiclone].
Topics: Azabicyclo Compounds; Drug Tolerance; Humans; Hypnotics and Sedatives; Piperazines; Substance Withdr | 1998 |
A comparative assessment of the risks and benefits of zopiclone: a review of 15 years' clinical experience.
Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Clinical Trials as Topic; Humans; Hypnotics and Seda | 1999 |
[Advantages and disadvantages of sleeping pills].
Topics: Azabicyclo Compounds; Benzodiazepines; Humans; Hypnotics and Sedatives; Piperazines; Sleep Initiatio | 1991 |
Zopiclone: another carriage on the tranquilliser train.
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Sleep Initiation and Maintenance | 1990 |
Zopiclone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as an hypnotic.
Topics: Anti-Anxiety Agents; Anticonvulsants; Anxiety; Azabicyclo Compounds; Benzodiazepines; Biotransformat | 1986 |
4 trials available for zopiclone and Chemical Dependence
| Article | Year |
|---|---|
Studies on the dependence-inducing potential of zopiclone and triazolam.
Topics: Adult; Anti-Anxiety Agents; Azabicyclo Compounds; Blood Pressure; Body Temperature; Double-Blind Met | 1983 |
Studies on the dependence-inducing potential of zopiclone and triazolam.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Azabicyclo Compounds; Double-Blind Method; Humans; Hypnotics | 1982 |
Evaluation of zopiclone physical dependence liability in normal volunteers.
Topics: Adult; Anxiety; Azabicyclo Compounds; Double-Blind Method; Hemodynamics; Humans; Hypnotics and Sedat | 1983 |
Evaluation of zopiclone physical dependence liability in normal volunteers.
Topics: Adult; Anxiety; Azabicyclo Compounds; Double-Blind Method; Electroencephalography; Hemodynamics; Hum | 1982 |
53 other studies available for zopiclone and Chemical Dependence
| Article | Year |
|---|---|
Are Seniors Dependent on Benzodiazepines? A National Clinical Survey of Substance Use Disorder.
Topics: Aged; Azabicyclo Compounds; Benzodiazepines; Female; Humans; Hypnotics and Sedatives; Logistic Model | 2021 |
The French addictovigilance network clinical assessment: Z-drugs, true false twins.
Topics: Adult; Aged; Azabicyclo Compounds; Female; France; Humans; Hypnotics and Sedatives; Male; Middle Age | 2017 |
An Insight into Z-Drug Abuse and Dependence: An Examination of Reports to the European Medicines Agency Database of Suspected Adverse Drug Reactions.
Topics: Acetamides; Adolescent; Adult; Azabicyclo Compounds; Databases, Factual; Drug Misuse; Drug-Related S | 2019 |
Pharmacoepidemiological characterisation of zolpidem and zopiclone usage.
Topics: Aged; Azabicyclo Compounds; Drug Utilization; Female; France; Humans; Hypnotics and Sedatives; Male; | 2013 |
[Private prescriptions of hypnotics and tranquilizers for statutory health-insured patients: regulatory framework versus reality of primary care].
Topics: Antidepressive Agents; Antipsychotic Agents; Azabicyclo Compounds; Benzodiazepines; Contract Service | 2014 |
[Perceptions of GPs and community pharmacists on hypnotic prescribing on private prescriptions].
Topics: Adult; Aged; Attitude of Health Personnel; Azabicyclo Compounds; Benzodiazepines; Data Collection; D | 2014 |
Injection of crushed tablets--a prospective observational study.
Topics: Adolescent; Adult; Azabicyclo Compounds; Benzodiazepines; Buprenorphine; C-Reactive Protein; Female; | 2014 |
Correlates of dependence and beliefs about the use of hypnotics among zolpidem and zopiclone users.
Topics: Adult; Azabicyclo Compounds; Depressive Disorder; Diagnosis, Dual (Psychiatry); Female; Hospitals; H | 2015 |
[Addiction is a matter of opinion].
Topics: Aged; Azabicyclo Compounds; Humans; Male; Physician-Patient Relations; Piperazines; Substance-Relate | 2015 |
Benzodiazepine and "Z-Drug" Dependence: Data From a Tertiary Care Center.
Topics: Acetamides; Adult; Azabicyclo Compounds; Bacterial Proteins; Benzodiazepines; Female; Humans; Hypnot | 2017 |
The relation between the blood benzodiazepine concentration and performance in suspected impaired drivers.
Topics: Accidents, Traffic; Automobile Driving; Azabicyclo Compounds; Benzodiazepines; Chi-Square Distributi | 2008 |
Impairment related to blood drug concentrations of zopiclone and zolpidem compared to alcohol in apprehended drivers.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alcoholic Intoxication; Automobile Driving; | 2009 |
A qualitative investigation of long-term zopiclone use and sleep quality among Vietnam war veterans with PTSD.
Topics: Australia; Azabicyclo Compounds; Cohort Studies; Combat Disorders; Follow-Up Studies; Humans; Hypnot | 2009 |
Regional variations of private prescriptions for the non-benzodiazepine hypnotics zolpidem and zopiclone in Germany.
Topics: Azabicyclo Compounds; Benzodiazepines; Databases, Factual; Drug Prescriptions; Germany; Humans; Hypn | 2010 |
Concentrations of zolpidem and zopiclone in venous blood samples from impaired drivers compared with femoral blood from forensic autopsies.
Topics: Adult; Aged; Automobile Driving; Azabicyclo Compounds; Central Nervous System Depressants; Chromatog | 2012 |
Clinical characteristics of cough mixture abusers referred to three substance abuse clinics in Hong Kong: a retrospective study.
Topics: Adult; Antitussive Agents; Azabicyclo Compounds; Codeine; Comorbidity; Diagnosis, Dual (Psychiatry); | 2012 |
Excessive use of zopiclone: a case report.
Topics: Aged; Azabicyclo Compounds; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Ove | 2002 |
Zopiclone dependence after insomnia related to torticollis.
Topics: Azabicyclo Compounds; Female; Humans; Hypnotics and Sedatives; Middle Aged; Piperazines; Sleep Initi | 2005 |
NICE: The National Institute of Clinical Excellence -- or Eccentricity? Reflections on the Z-drugs as hypnotics.
Topics: Acetamides; Azabicyclo Compounds; Benzodiazepines; Half-Life; Humans; Hypnotics and Sedatives; Piper | 2005 |
NICE review: not nice for patients!
Topics: Acetamides; Azabicyclo Compounds; Benzodiazepines; Half-Life; Humans; Hypnotics and Sedatives; Piper | 2005 |
A NICE missed opportunity?
Topics: Acetamides; Azabicyclo Compounds; Benzodiazepines; Drug Tolerance; Humans; Hypnotics and Sedatives; | 2005 |
Eszopiclone (Lunesta), a new hypnotic.
Topics: Azabicyclo Compounds; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; | 2005 |
[Are z-hypnotics better and safer sleeping pills than benzodiazepines?].
Topics: Acetamides; Azabicyclo Compounds; Benzodiazepines; Half-Life; Humans; Hypnotics and Sedatives; Piper | 2006 |
Zopiclone misuse: an update from Dublin.
Topics: Adult; Azabicyclo Compounds; Benzodiazepines; Comorbidity; Cross-Sectional Studies; Female; Hepatiti | 2007 |
WHO Expert Committee on Drug Dependence.
Topics: 4-Butyrolactone; Advisory Committees; Azabicyclo Compounds; Buprenorphine; Butorphanol; Catha; Drona | 2006 |
[High usage of zolpidem and zopiclone. Cross-sectional study using claims data].
Topics: Adult; Aged; Azabicyclo Compounds; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug P | 2008 |
Zopiclone: is it a pharmacologic agent for abuse?
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Male; Middle Aged; Piperazines; Risk Factors; | 2007 |
Addictive evidence.
Topics: Azabicyclo Compounds; Behavior, Addictive; Humans; Hypnotics and Sedatives; Piperazines; Practice Pa | 2008 |
Comparison of the reinforcing properties of zopiclone and triazolam in former alcoholics.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Azabicyclo Compounds; Capsules; Double-Blind Method; Electro | 1982 |
Dependence studies on zopiclone.
Topics: Animals; Azabicyclo Compounds; Barbiturates; Behavior, Animal; Diazepam; Humans; Hypnotics and Sedat | 1983 |
Dependence potential of zopiclone studied in monkeys.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Barbital; Behavior, Animal; Diazepam; Female; H | 1983 |
Dependence potential of zopiclone studied in monkeys.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Barbital; Diazepam; Female; Humans; Hypnotics a | 1982 |
Imovane--a benzodiazepine in disguise.
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Substance-Related Disorders | 1993 |
Zopiclone abuse among polydrug users.
Topics: Azabicyclo Compounds; Cross-Sectional Studies; Dose-Response Relationship, Drug; England; Female; Hu | 1996 |
Warning about Zopiclone misuse.
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Substance Abuse, Intravenous; Su | 1996 |
[Abuse of Imovane and Stilnoct].
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Pyridines; Substance-Related Dis | 1997 |
[Zopiclone dependence. Report of one case].
Topics: Azabicyclo Compounds; Female; Humans; Hypnotics and Sedatives; Middle Aged; Piperazines; Sleep Initi | 1997 |
Physical dependence on zopiclone: case reports.
Topics: Adult; Azabicyclo Compounds; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Piperazines | 1998 |
Physical dependence on zopiclone. Prescribing this drug to addicts may give rise to iatrogenic drug misuse.
Topics: Azabicyclo Compounds; Contraindications; Humans; Hypnotics and Sedatives; Piperazines; Substance-Rel | 1998 |
Physical dependence on zopiclone. Risk of dependence may be greater in those with dependent personalities.
Topics: Azabicyclo Compounds; Contraindications; Dependent Personality Disorder; Humans; Hypnotics and Sedat | 1998 |
Zopiclone, a current drug of misuse.
Topics: Azabicyclo Compounds; Hypnotics and Sedatives; Ireland; Piperazines; Substance-Related Disorders | 1998 |
[Risk of abuse when using zopiclone].
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Risk Factors; Substance-Related | 1998 |
[Dependency of non-benzodiazepine hypnotics. Two case reports].
Topics: Adult; Azabicyclo Compounds; Benzodiazepines; Depression; Humans; Hypnotics and Sedatives; Male; Mid | 1999 |
[Detection of zopiclone in many drivers--a sign of misuse or abuse].
Topics: Automobile Driving; Azabicyclo Compounds; Drug Prescriptions; Humans; Hypnotics and Sedatives; Norwa | 1999 |
[Development of drug withdrawal delirium after dependence on zolpidem and zoplicone].
Topics: Anxiety Disorders; Azabicyclo Compounds; Drug Therapy, Combination; Female; Humans; Hypnotics and Se | 1999 |
[A case of primary zopiclone dependence].
Topics: Anti-Anxiety Agents; Attention; Azabicyclo Compounds; Depression; Diazepam; Female; Humans; Hypnotic | 2001 |
Misuse of zopiclone and convulsions during withdrawal.
Topics: Adult; Azabicyclo Compounds; Depressive Disorder; Humans; Hypnotics and Sedatives; Male; Piperazines | 1991 |
Zopiclone.
Topics: Azabicyclo Compounds; Humans; Piperazines; Product Surveillance, Postmarketing; Sleep Initiation and | 1990 |
Imovane and narcotic addiction.
Topics: Adult; Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Male; Meperidine; Piperazines; Recurre | 1991 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Imovane addiction potential.
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Substance-Related Disorders | 1990 |
Imovane (zopiclone)
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Substance-Related Disorders | 1989 |
Imovane (zopiclone)
Topics: Azabicyclo Compounds; Humans; Hypnotics and Sedatives; Piperazines; Substance-Related Disorders | 1989 |