zopiclone has been researched along with Anxiety in 18 studies
zopiclone: S(+)-enantiomer of racemic zopiclone; azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; was term of zopiclone 2004-2007
zopiclone : A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the operating room, anxiety and comfort were moderate and did not differ significantly between groups on a 1-10 scale (median [25-75 percentile]): zopiclone: 2 [1-4] and 2." | 5.20 | Sedative premedication before surgery--A multicentre randomized study versus placebo. ( Alberti, C; Aveline, C; Beydon, L; Bildea, A; Bruna, J; Camut, N; Chrétien, JM; Daniel, V; Darsonval, A; Dupoiron, D; Liu, N; Malinovsky, JM; Marret, E; Rault, L; Rouxel, A; Schinkel, N, 2015) |
| "We evaluated racemic zopiclone, its (S)- and (R)-enantiomers and a metabolite, (S)-desmethylzopiclone, for their actions on locomotor activity, rotarod performance, the elevated plus maze and the Vogel conflict test of anxiety, and electroconvulsive shock-induced seizures duration." | 3.71 | Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite. ( Carlson, JN; Glick, SD; Haskew, R; Jerussi, TP; Maisonneuve, IM; Wacker, J, 2001) |
| "Zopiclone was associated with feelings of being troubled, tense, antagonistic and bored whereas temazepam produced drowsiness, clumsiness, dreaminess and sadness." | 2.66 | Subjective effects during administration and on discontinuation of zopiclone and temazepam in normal subjects. ( Frcka, G; Lader, M, 1987) |
| "Zopiclone was slightly superior to nitrazepam but was inferior both to flurazepam and flunitrazepam." | 2.65 | Comparative study of zopiclone, a novel hypnotic, and three benzodiazepines. ( Giercksky, KE; Wickstrøm, E, 1980) |
| "Zopiclone has a chiral centre, and demonstrates stereoselective pharmacokinetics." | 2.40 | Metabolism of anxiolytics and hypnotics: benzodiazepines, buspirone, zoplicone, and zolpidem. ( Chouinard, G; Lefko-Singh, K; Teboul, E, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kapil, V | 1 |
| Green, JL | 1 |
| Le Lait, C | 1 |
| Wood, DM | 1 |
| Dargan, PI | 1 |
| Beydon, L | 1 |
| Rouxel, A | 1 |
| Camut, N | 1 |
| Schinkel, N | 1 |
| Malinovsky, JM | 1 |
| Aveline, C | 1 |
| Marret, E | 1 |
| Bildea, A | 1 |
| Dupoiron, D | 1 |
| Liu, N | 1 |
| Daniel, V | 1 |
| Darsonval, A | 1 |
| Chrétien, JM | 1 |
| Rault, L | 1 |
| Bruna, J | 1 |
| Alberti, C | 1 |
| Belleville, G | 1 |
| Morin, CM | 1 |
| Wickstrøm, E | 1 |
| Giercksky, KE | 1 |
| Bond, A | 1 |
| Lader, M | 2 |
| Williams, M | 1 |
| Dorian, P | 2 |
| Sellers, EM | 2 |
| Kaplan, H | 2 |
| Hamilton, C | 2 |
| Inanaga, K | 1 |
| Tanaka, M | 1 |
| Mizuki, Y | 1 |
| Whitehead, C | 1 |
| Sanders, L | 1 |
| Appadurai, I | 1 |
| Power, I | 1 |
| Rosen, M | 1 |
| Robinson, J | 1 |
| Chouinard, G | 1 |
| Lefko-Singh, K | 1 |
| Teboul, E | 1 |
| Carlson, JN | 1 |
| Haskew, R | 1 |
| Wacker, J | 1 |
| Maisonneuve, IM | 1 |
| Glick, SD | 1 |
| Jerussi, TP | 1 |
| Weizman, R | 1 |
| Paz, L | 1 |
| Peter, Y | 1 |
| Toren, P | 1 |
| Pick, CG | 1 |
| Kataoka, Y | 2 |
| Shibata, K | 2 |
| Miyazaki, A | 2 |
| Inoue, Y | 1 |
| Tominaga, K | 2 |
| Koizumi, S | 1 |
| Ueki, S | 3 |
| Niwa, M | 1 |
| Yamashita, K | 1 |
| Goa, KL | 1 |
| Heel, RC | 1 |
| Yamamoto, T | 1 |
| Frcka, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of Two Modes of Premedication in Surgery - PREMED Study[NCT01549691] | Phase 4 | 455 participants (Anticipated) | Interventional | 2012-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for zopiclone and Anxiety
| Article | Year |
|---|---|
Anxioselective anxiolytics.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Benzodiazepines; Brain Chemi | 1983 |
Metabolism of anxiolytics and hypnotics: benzodiazepines, buspirone, zoplicone, and zolpidem.
Topics: Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Benzodiazepines; Buspirone; Cytochrome P-450 Enz | 1999 |
Zopiclone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as an hypnotic.
Topics: Anti-Anxiety Agents; Anticonvulsants; Anxiety; Azabicyclo Compounds; Benzodiazepines; Biotransformat | 1986 |
7 trials available for zopiclone and Anxiety
| Article | Year |
|---|---|
Sedative premedication before surgery--A multicentre randomized study versus placebo.
Topics: Adolescent; Adult; Affect; Aged; Alprazolam; Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Dou | 2015 |
Hypnotic discontinuation in chronic insomnia: impact of psychological distress, readiness to change, and self-efficacy.
Topics: Acetamides; Adaptation, Psychological; Adult; Aged; Anxiety; Attitude to Health; Azabicyclo Compound | 2008 |
Comparative study of zopiclone, a novel hypnotic, and three benzodiazepines.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Attention; Azabicyclo Compounds; Female; Flunitrazepam; Fluraze | 1980 |
Evaluation of zopiclone physical dependence liability in normal volunteers.
Topics: Adult; Anxiety; Azabicyclo Compounds; Double-Blind Method; Hemodynamics; Humans; Hypnotics and Sedat | 1983 |
Evaluation of zopiclone physical dependence liability in normal volunteers.
Topics: Adult; Anxiety; Azabicyclo Compounds; Double-Blind Method; Electroencephalography; Hemodynamics; Hum | 1982 |
Zopiclone as a preoperative night hypnotic: a double-blind comparison with temazepam and placebo.
Topics: Adolescent; Adult; Aged; Anxiety; Azabicyclo Compounds; Double-Blind Method; Female; Flicker Fusion; | 1994 |
Subjective effects during administration and on discontinuation of zopiclone and temazepam in normal subjects.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Arousal; Azabicyclo Compounds; Female; Humans; Hypnotics and Se | 1987 |
8 other studies available for zopiclone and Anxiety
| Article | Year |
|---|---|
Misuse of benzodiazepines and Z-drugs in the UK.
Topics: Acetamides; Adolescent; Adult; Anxiety; Azabicyclo Compounds; Benzodiazepines; Female; Humans; Hypno | 2014 |
Correlations among measures of response to benzodiazepines in man.
Topics: Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Benzodiazepines; Cognition; Electroencephalograp | 1983 |
Prediction of clinical efficacy of zopiclone by utilizing two psychophysiological tools in healthy volunteers.
Topics: Adolescent; Adult; Anxiety; Azabicyclo Compounds; Dose-Response Relationship, Drug; Electroencephalo | 1982 |
Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Azabicyclo Compounds; Diazepam; | 2001 |
Behavioral effects of agents active at the gamma-aminobutyric acid receptor complex in the staircase paradigm.
Topics: Acetates; Adjuvants, Immunologic; Amines; Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compound | 2001 |
Involvement of the dorsal hippocampus in mediation of the antianxiety action of tandospirone, a 5-hydroxytryptamine1A agonistic anxiolytic.
Topics: Animals; Anxiety; Azabicyclo Compounds; Behavior, Animal; Diazepam; Hippocampus; Hypnotics and Sedat | 1991 |
A key role of the mammillary body in mediation of the antianxiety action of zopiclone, a cyclopyrrolone derivative.
Topics: Animals; Anxiety; Azabicyclo Compounds; Benzodiazepines; Discrimination Learning; Hypnotics and Seda | 1989 |
A new method for screening anxiolytic drugs in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Diazepam; Drug Evaluation, Preclinical; | 1987 |