Page last updated: 2024-11-06

zopiclone and Aging

zopiclone has been researched along with Aging in 7 studies

zopiclone: S(+)-enantiomer of racemic zopiclone; azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; was term of zopiclone 2004-2007
zopiclone : A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"This article will review the causes of insomnia in the elderly, the approach to patient evaluation, and the nonpharmacologic and pharmacologic treatment of insomnia."2.43Insomnia in the elderly: cause, approach, and treatment. ( Gammack, JK; Kamel, NS, 2006)
" Plasma kinetics of ZD are generally well described by a two-compartment open model; in man, terminal half-life is 4-5 h; total body clearance is large (300 ml/mn), renal clearance very low (10 ml/min)."1.27Pharmacokinetics and metabolism of zopiclone. ( Dreyfus, JF; Gaillot, J; Heusse, D; Hougton, GW; Marc Aurele, J, 1983)
" Plasma kinetics of ZD are generally well described by a two-compartment open model; in man, terminal half-life is 4-5 h; total body clearance is large (300 ml/mn), renal clearance very low (10 ml/min)."1.26Pharmacokinetics and metabolism of zopiclone. ( Dreyfus, JF; Gaillot, J; Heusse, D; Hougton, GW; Marc Aurele, J, 1982)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19903 (42.86)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Treves, N1
Perlman, A1
Kolenberg Geron, L1
Asaly, A1
Matok, I1
Bocca, ML1
Marie, S1
Lelong-Boulouard, V1
Bertran, F1
Couque, C1
Desfemmes, T1
Berthelon, C1
Amato, JN1
Moessinger, M1
Paillet-Loilier, M1
Coquerel, A1
Denise, P1
Zhao, CS1
Puurunen, K1
Schallert, T1
Sivenius, J1
Jolkkonen, J1
Kamel, NS1
Gammack, JK1
Gaillot, J2
Heusse, D2
Hougton, GW2
Marc Aurele, J2
Dreyfus, JF2
Wright, NA1
Belyavin, A1
Borland, RG1
Nicholson, AN1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Benefits of Individualized Advice Administration on Quality of Sleep for the Elderly Living at Home Prospective, Monocentric and Open Study[NCT03594851]45 participants (Actual)Interventional2018-01-08Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for zopiclone and Aging

ArticleYear
Z-drugs and risk for falls and fractures in older adults-a systematic review and meta-analysis.
    Age and ageing, 2018, 03-01, Volume: 47, Issue:2

    Topics: Accidental Falls; Acetamides; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Azabicyclo Compoun

2018
Insomnia in the elderly: cause, approach, and treatment.
    The American journal of medicine, 2006, Volume: 119, Issue:6

    Topics: Acetamides; Aged; Aging; Antidepressive Agents; Azabicyclo Compounds; Behavior Therapy; Benzodiazepi

2006

Trials

1 trial available for zopiclone and Aging

ArticleYear
Zolpidem and zopiclone impair similarly monotonous driving performance after a single nighttime intake in aged subjects.
    Psychopharmacology, 2011, Volume: 214, Issue:3

    Topics: Aged; Aging; Analysis of Variance; Automobile Driving; Azabicyclo Compounds; Circadian Rhythm; Cross

2011

Other Studies

4 other studies available for zopiclone and Aging

ArticleYear
Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone.
    Behavioural brain research, 2005, May-28, Volume: 160, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Azabicyclo Compounds; Behavior, Animal; Brain Injuries; Cerebr

2005
Pharmacokinetics and metabolism of zopiclone.
    Pharmacology, 1983, Volume: 27 Suppl 2

    Topics: Administration, Oral; Aged; Aging; Animals; Autoradiography; Azabicyclo Compounds; Biotransformation

1983
Pharmacokinetics and metabolism of zopiclone.
    International pharmacopsychiatry, 1982, Volume: 17 Suppl 2

    Topics: Administration, Oral; Adult; Aged; Aging; Animals; Autoradiography; Azabicyclo Compounds; Dogs; Fema

1982
Modulation of delta activity by hypnotics in middle-aged subjects: studies with a benzodiazepine (flurazepam) and a cyclopyrrolone (zopiclone).
    Sleep, 1986, Volume: 9, Issue:2

    Topics: Aging; Azabicyclo Compounds; Delta Rhythm; Flurazepam; Humans; Hypnotics and Sedatives; Male; Middle

1986