zopiclone and Aging
zopiclone has been researched along with Aging in 7 studies
zopiclone: S(+)-enantiomer of racemic zopiclone; azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; was term of zopiclone 2004-2007
zopiclone : A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This article will review the causes of insomnia in the elderly, the approach to patient evaluation, and the nonpharmacologic and pharmacologic treatment of insomnia." | 2.43 | Insomnia in the elderly: cause, approach, and treatment. ( Gammack, JK; Kamel, NS, 2006) |
| " Plasma kinetics of ZD are generally well described by a two-compartment open model; in man, terminal half-life is 4-5 h; total body clearance is large (300 ml/mn), renal clearance very low (10 ml/min)." | 1.27 | Pharmacokinetics and metabolism of zopiclone. ( Dreyfus, JF; Gaillot, J; Heusse, D; Hougton, GW; Marc Aurele, J, 1983) |
| " Plasma kinetics of ZD are generally well described by a two-compartment open model; in man, terminal half-life is 4-5 h; total body clearance is large (300 ml/mn), renal clearance very low (10 ml/min)." | 1.26 | Pharmacokinetics and metabolism of zopiclone. ( Dreyfus, JF; Gaillot, J; Heusse, D; Hougton, GW; Marc Aurele, J, 1982) |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Treves, N | 1 |
| Perlman, A | 1 |
| Kolenberg Geron, L | 1 |
| Asaly, A | 1 |
| Matok, I | 1 |
| Bocca, ML | 1 |
| Marie, S | 1 |
| Lelong-Boulouard, V | 1 |
| Bertran, F | 1 |
| Couque, C | 1 |
| Desfemmes, T | 1 |
| Berthelon, C | 1 |
| Amato, JN | 1 |
| Moessinger, M | 1 |
| Paillet-Loilier, M | 1 |
| Coquerel, A | 1 |
| Denise, P | 1 |
| Zhao, CS | 1 |
| Puurunen, K | 1 |
| Schallert, T | 1 |
| Sivenius, J | 1 |
| Jolkkonen, J | 1 |
| Kamel, NS | 1 |
| Gammack, JK | 1 |
| Gaillot, J | 2 |
| Heusse, D | 2 |
| Hougton, GW | 2 |
| Marc Aurele, J | 2 |
| Dreyfus, JF | 2 |
| Wright, NA | 1 |
| Belyavin, A | 1 |
| Borland, RG | 1 |
| Nicholson, AN | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Benefits of Individualized Advice Administration on Quality of Sleep for the Elderly Living at Home Prospective, Monocentric and Open Study[NCT03594851] | 45 participants (Actual) | Interventional | 2018-01-08 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for zopiclone and Aging
| Article | Year |
|---|---|
Z-drugs and risk for falls and fractures in older adults-a systematic review and meta-analysis.
Topics: Accidental Falls; Acetamides; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Azabicyclo Compoun | 2018 |
Insomnia in the elderly: cause, approach, and treatment.
Topics: Acetamides; Aged; Aging; Antidepressive Agents; Azabicyclo Compounds; Behavior Therapy; Benzodiazepi | 2006 |
Trials
1 trial available for zopiclone and Aging
| Article | Year |
|---|---|
Zolpidem and zopiclone impair similarly monotonous driving performance after a single nighttime intake in aged subjects.
Topics: Aged; Aging; Analysis of Variance; Automobile Driving; Azabicyclo Compounds; Circadian Rhythm; Cross | 2011 |
Other Studies
4 other studies available for zopiclone and Aging
| Article | Year |
|---|---|
Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone.
Topics: Aging; Analysis of Variance; Animals; Azabicyclo Compounds; Behavior, Animal; Brain Injuries; Cerebr | 2005 |
Pharmacokinetics and metabolism of zopiclone.
Topics: Administration, Oral; Aged; Aging; Animals; Autoradiography; Azabicyclo Compounds; Biotransformation | 1983 |
Pharmacokinetics and metabolism of zopiclone.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Autoradiography; Azabicyclo Compounds; Dogs; Fema | 1982 |
Modulation of delta activity by hypnotics in middle-aged subjects: studies with a benzodiazepine (flurazepam) and a cyclopyrrolone (zopiclone).
Topics: Aging; Azabicyclo Compounds; Delta Rhythm; Flurazepam; Humans; Hypnotics and Sedatives; Male; Middle | 1986 |