zonisamide has been researched along with Tuberous Sclerosis in 3 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Tuberous Sclerosis: Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examined the efficacy and safety of zonisamide as monotherapy in pediatric patients with epilepsy." | 9.11 | Effects of zonisamide monotherapy in children with epilepsy. ( Kumagai, N; Maezawa, M; Seki, T, 2004) |
| "Zonisamide (ZNS) is a new generation antiepileptic drug (AED) used in refractory epilepsy." | 8.12 | Effectiveness of zonisamide in childhood refractory epilepsy. ( Aslan, M; Gungor, S, 2022) |
| "A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated within a paediatric epilepsy surgery program." | 5.42 | [Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis]. ( Blanco-Beregana, M; Budke, M; Fournier-Del Castillo, MC; Garcia-Fernandez, M; Garcia-Penas, JJ; Melero-Llorente, J; Perez-Jimenez, MÁ; Robles-Bermejo, F, 2015) |
| "This study examined the efficacy and safety of zonisamide as monotherapy in pediatric patients with epilepsy." | 5.11 | Effects of zonisamide monotherapy in children with epilepsy. ( Kumagai, N; Maezawa, M; Seki, T, 2004) |
| "Zonisamide (ZNS) is a new generation antiepileptic drug (AED) used in refractory epilepsy." | 4.12 | Effectiveness of zonisamide in childhood refractory epilepsy. ( Aslan, M; Gungor, S, 2022) |
| "A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated within a paediatric epilepsy surgery program." | 1.42 | [Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis]. ( Blanco-Beregana, M; Budke, M; Fournier-Del Castillo, MC; Garcia-Fernandez, M; Garcia-Penas, JJ; Melero-Llorente, J; Perez-Jimenez, MÁ; Robles-Bermejo, F, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Aslan, M | 1 |
| Gungor, S | 1 |
| Fournier-Del Castillo, MC | 1 |
| Melero-Llorente, J | 1 |
| Blanco-Beregana, M | 1 |
| Robles-Bermejo, F | 1 |
| Budke, M | 1 |
| Garcia-Fernandez, M | 1 |
| Garcia-Penas, JJ | 1 |
| Perez-Jimenez, MÁ | 1 |
| Seki, T | 1 |
| Kumagai, N | 1 |
| Maezawa, M | 1 |
1 trial available for zonisamide and Tuberous Sclerosis
| Article | Year |
|---|---|
Effects of zonisamide monotherapy in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Electroencephalo | 2004 |
2 other studies available for zonisamide and Tuberous Sclerosis
| Article | Year |
|---|---|
Effectiveness of zonisamide in childhood refractory epilepsy.
Topics: Child; Drug Resistant Epilepsy; Epilepsies, Partial; Epilepsy; Humans; Reproducibility of Results; R | 2022 |
[Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis].
Topics: Acetamides; Anticonvulsants; Benzodiazepines; Child; Clobazam; Cognition Disorders; Dibenzazepines; | 2015 |