Page last updated: 2024-11-05

zonisamide and Tremor

zonisamide has been researched along with Tremor in 11 studies

Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.

Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.

Research Excerpts

ExcerptRelevanceReference
"Zonisamide at a dose of 25 mg per day did not improve tremor in tremor-dominant PD patients, however, a positive trend was seen as compared to Placebo in the UPDRS tremor score."9.51Zonisamide add-on in tremor-dominant Parkinson's disease- A randomized controlled clinical trial. ( Bhat, P; Elavarasi, A; Goyal, V; Pandit, AK; Pillai, KS; Prasad, K; Radhakrishnan, DM; Rajan, R; Singh, MB; Srivastava, AK; Srivastava, MP; Vishnu, VY, 2022)
"To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs)."7.75Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. ( Kondo, T; Kubo, T; Miwa, H; Suzuki, A, 2009)
"Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied."7.74Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008)
"Zonisamide at a dose of 25 mg per day did not improve tremor in tremor-dominant PD patients, however, a positive trend was seen as compared to Placebo in the UPDRS tremor score."5.51Zonisamide add-on in tremor-dominant Parkinson's disease- A randomized controlled clinical trial. ( Bhat, P; Elavarasi, A; Goyal, V; Pandit, AK; Pillai, KS; Prasad, K; Radhakrishnan, DM; Rajan, R; Singh, MB; Srivastava, AK; Srivastava, MP; Vishnu, VY, 2022)
"We aimed to evaluate the effect of zonisamide (ZNS) on motor symptoms and nonmotor symptoms such as depressive symptoms and sleep problems in Parkinson's disease (PD) patients with or without tremor."5.41Zonisamide effects on sleep problems and depressive symptoms in Parkinson's disease. ( Fujita, H; Funakoshi, K; Haruyama, Y; Hirata, K; Kadowaki, T; Matsubara, T; Suzuki, K; Watanabe, Y, 2021)
"Generally, resting tremor of patients with Parkinson's disease is not the main therapeutic target in this disease."5.32[Effect of zonisamide on resting tremor resistant to antiparkinsonian medication]. ( Kohmoto, J; Kondo, T; Miwa, H; Nakanishi, I, 2003)
"Zonisamide is a new antiepileptic drug which has a wide range of antiepileptic efficacy."5.28[Zonisamide induced tremor--report of two cases]. ( Taira, T, 1992)
"To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs)."3.75Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. ( Kondo, T; Kubo, T; Miwa, H; Suzuki, A, 2009)
"Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied."3.74Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008)
"Generally, resting tremor of patients with Parkinson's disease is not the main therapeutic target in this disease."1.32[Effect of zonisamide on resting tremor resistant to antiparkinsonian medication]. ( Kohmoto, J; Kondo, T; Miwa, H; Nakanishi, I, 2003)
"Zonisamide is a new antiepileptic drug which has a wide range of antiepileptic efficacy."1.28[Zonisamide induced tremor--report of two cases]. ( Taira, T, 1992)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's3 (27.27)29.6817
2010's4 (36.36)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Pillai, KS1
Bhat, P1
Srivastava, AK1
Rajan, R1
Radhakrishnan, DM1
Elavarasi, A1
Srivastava, MP1
Singh, MB1
Vishnu, VY1
Prasad, K1
Pandit, AK1
Goyal, V1
Suzuki, K1
Fujita, H1
Matsubara, T1
Haruyama, Y1
Kadowaki, T1
Funakoshi, K1
Watanabe, Y1
Hirata, K1
Hara, N1
Nezu, T1
Kobatake, K1
Morino, H1
Kawakami, H1
Maruyama, H1
Miwa, H3
Kubo, T1
Suzuki, A1
Kondo, T3
Iijima, M1
Osawa, M1
Kobayashi, M1
Uchiyama, S1
Suda, S1
Yamazaki, M1
Katsura, K1
Fukuchi, T1
Kaneko, N1
Ueda, M1
Nagayama, H1
Katayama, Y1
Mochio, S1
Sengoku, R1
Kono, Y1
Morita, M1
Mitsumura, H1
Takagi, S1
Kamiyama, T1
Oka, H1
Nakanishi, I1
Kohmoto, J1
Hama, K1
Kajimoto, Y1
Takigawa, T1
Mima, T1
Saida, K1
Kawasaki, J1
Shibasaki, H1
Taira, T1

Trials

2 trials available for zonisamide and Tremor

ArticleYear
Zonisamide add-on in tremor-dominant Parkinson's disease- A randomized controlled clinical trial.
    Parkinsonism & related disorders, 2022, Volume: 105

    Topics: Double-Blind Method; Essential Tremor; Humans; Parkinson Disease; Treatment Outcome; Tremor; Zonisam

2022
Zonisamide effects on sleep problems and depressive symptoms in Parkinson's disease.
    Brain and behavior, 2021, Volume: 11, Issue:3

    Topics: Depression; Humans; Parkinson Disease; Sleep Wake Disorders; Tremor; Zonisamide

2021

Other Studies

9 other studies available for zonisamide and Tremor

ArticleYear
Treatment of intractable resting tremor of spinocerebellar ataxia 42 with zonisamide.
    Journal of the neurological sciences, 2019, 01-15, Volume: 396

    Topics: Adult; Anticonvulsants; Calcium Channels, T-Type; Cerebellum; Female; Humans; Mutation; Spinocerebel

2019
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect.
    Parkinsonism & related disorders, 2009, Volume: 15, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Cell Count; Disease Models, Animal; Dose-Response Relationship, Dru

2009
Efficacy of zonisamide in a case of Parkinson's disease with intractable resting and re-emergent tremor.
    European journal of neurology, 2011, Volume: 18, Issue:4

    Topics: Aged; Antiparkinson Agents; Electromyography; Female; Humans; Isoxazoles; Parkinson Disease; Rest; S

2011
Dramatic response to zonisamide of post-subarachnoid hemorrhage Holmes' tremor.
    Journal of neurology, 2012, Volume: 259, Issue:1

    Topics: Aged; Anticonvulsants; Brain Edema; Female; Humans; Image Processing, Computer-Assisted; Isoxazoles;

2012
Actigraphic study of tremor before and after treatment with zonisamide in patients with Parkinson's disease.
    Parkinsonism & related disorders, 2012, Volume: 18, Issue:7

    Topics: Actigraphy; Anticonvulsants; Humans; Isoxazoles; Motor Activity; Parkinson Disease; Treatment Outcom

2012
[Effect of zonisamide on resting tremor resistant to antiparkinsonian medication].
    No to shinkei = Brain and nerve, 2003, Volume: 55, Issue:8

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Antiparkinson Agents; Humans; Isoxazoles; Levodopa; Male;

2003
Effects of zonisamide on experimental tremors in rats.
    Parkinsonism & related disorders, 2008, Volume: 14, Issue:1

    Topics: Animals; Anticonvulsants; Central Nervous System Stimulants; Cholinesterase Inhibitors; Harmaline; I

2008
[A case of cortical reflex myoclonus manifesting tremor].
    Rinsho shinkeigaku = Clinical neurology, 1997, Volume: 37, Issue:11

    Topics: Anticonvulsants; Cerebral Cortex; Clonazepam; Evoked Potentials, Somatosensory; Female; Humans; Isox

1997
[Zonisamide induced tremor--report of two cases].
    No to shinkei = Brain and nerve, 1992, Volume: 44, Issue:1

    Topics: Adult; Anticonvulsants; Electromyography; Female; Humans; Isoxazoles; Posture; Rest; Tremor; Zonisam

1992