zonisamide and Tremor
zonisamide has been researched along with Tremor in 11 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zonisamide at a dose of 25 mg per day did not improve tremor in tremor-dominant PD patients, however, a positive trend was seen as compared to Placebo in the UPDRS tremor score." | 9.51 | Zonisamide add-on in tremor-dominant Parkinson's disease- A randomized controlled clinical trial. ( Bhat, P; Elavarasi, A; Goyal, V; Pandit, AK; Pillai, KS; Prasad, K; Radhakrishnan, DM; Rajan, R; Singh, MB; Srivastava, AK; Srivastava, MP; Vishnu, VY, 2022) |
| "To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs)." | 7.75 | Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. ( Kondo, T; Kubo, T; Miwa, H; Suzuki, A, 2009) |
| "Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied." | 7.74 | Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008) |
| "Zonisamide at a dose of 25 mg per day did not improve tremor in tremor-dominant PD patients, however, a positive trend was seen as compared to Placebo in the UPDRS tremor score." | 5.51 | Zonisamide add-on in tremor-dominant Parkinson's disease- A randomized controlled clinical trial. ( Bhat, P; Elavarasi, A; Goyal, V; Pandit, AK; Pillai, KS; Prasad, K; Radhakrishnan, DM; Rajan, R; Singh, MB; Srivastava, AK; Srivastava, MP; Vishnu, VY, 2022) |
| "We aimed to evaluate the effect of zonisamide (ZNS) on motor symptoms and nonmotor symptoms such as depressive symptoms and sleep problems in Parkinson's disease (PD) patients with or without tremor." | 5.41 | Zonisamide effects on sleep problems and depressive symptoms in Parkinson's disease. ( Fujita, H; Funakoshi, K; Haruyama, Y; Hirata, K; Kadowaki, T; Matsubara, T; Suzuki, K; Watanabe, Y, 2021) |
| "Generally, resting tremor of patients with Parkinson's disease is not the main therapeutic target in this disease." | 5.32 | [Effect of zonisamide on resting tremor resistant to antiparkinsonian medication]. ( Kohmoto, J; Kondo, T; Miwa, H; Nakanishi, I, 2003) |
| "Zonisamide is a new antiepileptic drug which has a wide range of antiepileptic efficacy." | 5.28 | [Zonisamide induced tremor--report of two cases]. ( Taira, T, 1992) |
| "To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs)." | 3.75 | Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. ( Kondo, T; Kubo, T; Miwa, H; Suzuki, A, 2009) |
| "Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied." | 3.74 | Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008) |
| "Generally, resting tremor of patients with Parkinson's disease is not the main therapeutic target in this disease." | 1.32 | [Effect of zonisamide on resting tremor resistant to antiparkinsonian medication]. ( Kohmoto, J; Kondo, T; Miwa, H; Nakanishi, I, 2003) |
| "Zonisamide is a new antiepileptic drug which has a wide range of antiepileptic efficacy." | 1.28 | [Zonisamide induced tremor--report of two cases]. ( Taira, T, 1992) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Pillai, KS | 1 |
| Bhat, P | 1 |
| Srivastava, AK | 1 |
| Rajan, R | 1 |
| Radhakrishnan, DM | 1 |
| Elavarasi, A | 1 |
| Srivastava, MP | 1 |
| Singh, MB | 1 |
| Vishnu, VY | 1 |
| Prasad, K | 1 |
| Pandit, AK | 1 |
| Goyal, V | 1 |
| Suzuki, K | 1 |
| Fujita, H | 1 |
| Matsubara, T | 1 |
| Haruyama, Y | 1 |
| Kadowaki, T | 1 |
| Funakoshi, K | 1 |
| Watanabe, Y | 1 |
| Hirata, K | 1 |
| Hara, N | 1 |
| Nezu, T | 1 |
| Kobatake, K | 1 |
| Morino, H | 1 |
| Kawakami, H | 1 |
| Maruyama, H | 1 |
| Miwa, H | 3 |
| Kubo, T | 1 |
| Suzuki, A | 1 |
| Kondo, T | 3 |
| Iijima, M | 1 |
| Osawa, M | 1 |
| Kobayashi, M | 1 |
| Uchiyama, S | 1 |
| Suda, S | 1 |
| Yamazaki, M | 1 |
| Katsura, K | 1 |
| Fukuchi, T | 1 |
| Kaneko, N | 1 |
| Ueda, M | 1 |
| Nagayama, H | 1 |
| Katayama, Y | 1 |
| Mochio, S | 1 |
| Sengoku, R | 1 |
| Kono, Y | 1 |
| Morita, M | 1 |
| Mitsumura, H | 1 |
| Takagi, S | 1 |
| Kamiyama, T | 1 |
| Oka, H | 1 |
| Nakanishi, I | 1 |
| Kohmoto, J | 1 |
| Hama, K | 1 |
| Kajimoto, Y | 1 |
| Takigawa, T | 1 |
| Mima, T | 1 |
| Saida, K | 1 |
| Kawasaki, J | 1 |
| Shibasaki, H | 1 |
| Taira, T | 1 |
Trials
2 trials available for zonisamide and Tremor
| Article | Year |
|---|---|
Zonisamide add-on in tremor-dominant Parkinson's disease- A randomized controlled clinical trial.
Topics: Double-Blind Method; Essential Tremor; Humans; Parkinson Disease; Treatment Outcome; Tremor; Zonisam | 2022 |
Zonisamide effects on sleep problems and depressive symptoms in Parkinson's disease.
Topics: Depression; Humans; Parkinson Disease; Sleep Wake Disorders; Tremor; Zonisamide | 2021 |
Other Studies
9 other studies available for zonisamide and Tremor
| Article | Year |
|---|---|
Treatment of intractable resting tremor of spinocerebellar ataxia 42 with zonisamide.
Topics: Adult; Anticonvulsants; Calcium Channels, T-Type; Cerebellum; Female; Humans; Mutation; Spinocerebel | 2019 |
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect.
Topics: Animals; Anticonvulsants; Brain; Cell Count; Disease Models, Animal; Dose-Response Relationship, Dru | 2009 |
Efficacy of zonisamide in a case of Parkinson's disease with intractable resting and re-emergent tremor.
Topics: Aged; Antiparkinson Agents; Electromyography; Female; Humans; Isoxazoles; Parkinson Disease; Rest; S | 2011 |
Dramatic response to zonisamide of post-subarachnoid hemorrhage Holmes' tremor.
Topics: Aged; Anticonvulsants; Brain Edema; Female; Humans; Image Processing, Computer-Assisted; Isoxazoles; | 2012 |
Actigraphic study of tremor before and after treatment with zonisamide in patients with Parkinson's disease.
Topics: Actigraphy; Anticonvulsants; Humans; Isoxazoles; Motor Activity; Parkinson Disease; Treatment Outcom | 2012 |
[Effect of zonisamide on resting tremor resistant to antiparkinsonian medication].
Topics: Aged; Aged, 80 and over; Anticonvulsants; Antiparkinson Agents; Humans; Isoxazoles; Levodopa; Male; | 2003 |
Effects of zonisamide on experimental tremors in rats.
Topics: Animals; Anticonvulsants; Central Nervous System Stimulants; Cholinesterase Inhibitors; Harmaline; I | 2008 |
[A case of cortical reflex myoclonus manifesting tremor].
Topics: Anticonvulsants; Cerebral Cortex; Clonazepam; Evoked Potentials, Somatosensory; Female; Humans; Isox | 1997 |
[Zonisamide induced tremor--report of two cases].
Topics: Adult; Anticonvulsants; Electromyography; Female; Humans; Isoxazoles; Posture; Rest; Tremor; Zonisam | 1992 |