zonisamide has been researched along with Spinocerebellar Ataxias in 3 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Spinocerebellar Ataxias: A group of predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Early-onset severe spinocerebellar ataxia 42 with neurodevelopmental deficits (SCA42ND, MIM#604065) is an ultrarare autosomal dominant syndrome related to de novo CACNA1G gain-of-function pathogenic variants." | 1.62 | Early-onset severe spinocerebellar ataxia 42 with neurodevelopmental deficits (SCA42ND): Case report, pharmacological trial, and literature review. ( Bolasell, M; Casas-Alba, D; Fernández-Fernández, JM; López-Sala, L; Mari-Vico, R; Martínez-Monseny, AF; Martorell, L; Muchart, J; Pérez-Ordóñez, M; Serrano, M, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Casas-Alba, D | 1 |
| López-Sala, L | 1 |
| Pérez-Ordóñez, M | 1 |
| Mari-Vico, R | 1 |
| Bolasell, M | 1 |
| Martínez-Monseny, AF | 1 |
| Muchart, J | 1 |
| Fernández-Fernández, JM | 1 |
| Martorell, L | 1 |
| Serrano, M | 1 |
| Hara, N | 2 |
| Morino, H | 2 |
| Matsuda, Y | 1 |
| Satoh, K | 1 |
| Hashimoto, K | 1 |
| Maruyama, H | 2 |
| Kawakami, H | 2 |
| Nezu, T | 1 |
| Kobatake, K | 1 |
3 other studies available for zonisamide and Spinocerebellar Ataxias
| Article | Year |
|---|---|
Early-onset severe spinocerebellar ataxia 42 with neurodevelopmental deficits (SCA42ND): Case report, pharmacological trial, and literature review.
Topics: Age of Onset; Alleles; Calcium Channels, T-Type; Child, Preschool; Epilepsy; Female; Gain of Functio | 2021 |
Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel Ca
Topics: Calcium Channels, T-Type; Dihydropyridines; Electrophysiological Phenomena; HEK293 Cells; Humans; Mu | 2020 |
Treatment of intractable resting tremor of spinocerebellar ataxia 42 with zonisamide.
Topics: Adult; Anticonvulsants; Calcium Channels, T-Type; Cerebellum; Female; Humans; Mutation; Spinocerebel | 2019 |