Page last updated: 2024-11-05

zonisamide and Seizures

zonisamide has been researched along with Seizures in 65 studies

Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Zonisamide treatment was generally well tolerated and was associated with significant reductions in seizure frequency in this pediatric population with a variety of both partial and generalized medically refractory epilepsy syndromes."9.14Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy. ( Conry, JA; Pellock, JM; Shinnar, S, 2009)
"To examine the safety and efficacy of zonisamide in treating myoclonic seizures associated with progressive myoclonic epilepsy (PME), in an open-label setting."9.13Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study. ( Conry, JA; Murphy, JV; Vossler, DG, 2008)
"To assess the therapeutic efficacy and safety of antiseizure medication (ASM) for a minimum of 6 months, including zonisamide (ZNS), in feline idiopathic epilepsy at a referral hospital in Japan."8.31Evaluation of antiseizure medications including zonisamide in feline idiopathic epilepsy at a referral hospital in Japan. ( Maeda, S; Motegi, T; Yonezawa, T; Yoshida, S, 2023)
"To investigate caregivers' assessments of outcome in dogs with idiopathic epilepsy (IE) administered levetiracetam (LEV), zonisamide (ZNS), or phenobarbital (PB) monotherapy."8.31Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy. ( Gristina, BR; Muñana, KR; Nettifee, JA; Waldron, RJ, 2023)
"Zonisamide (ZNS) is a new generation antiepileptic drug (AED) used in refractory epilepsy."8.12Effectiveness of zonisamide in childhood refractory epilepsy. ( Aslan, M; Gungor, S, 2022)
"The present findings revealed that zonisamide treatment prevented the development of seizures in animals."7.88A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures. ( Attri, SV; Kumar, B; Medhi, B; Modi, M; Patial, A; Saikia, B, 2018)
"Zonisamide is licensed for adjunctive therapy for partial-onset seizures with or without secondary generalisation in patients 6 years and older and as monotherapy for the treatment of partial seizures in adult patients with newly diagnosed epilepsy, and shows a favourable pharmacokinetic profile with low interaction potential with other drugs."7.83Retention, dosing, tolerability and patient reported seizure outcome of Zonisamide as only add-on treatment under real-life conditions in adult patients with partial onset seizures: Results of the observational study ZOOM. ( Baulac, M; Hamer, H; Kockelmann, E; McMurray, R, 2016)
"This retrospective study examined the efficacy and safety of zonisamide for Thai children and adolescents with intractable seizures."7.81Efficacy and safety of zonisamide in Thai children and adolescents with intractable seizures. ( Khongkhatithum, C; Thampratankul, L; Visudtibhan, A, 2015)
"Concerning zonisamide (ZNS) therapy, data on sexual dysfunction are not available either in patients with epilepsy or in patients with brain tumor-related epilepsy."7.77Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on. ( Dinapoli, L; Jandolo, B; Maschio, M; Saveriano, F, 2011)
" Both the patients developed seizures of various types that have been successfully treated with zonisamide."7.74Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: a successful use of zonisamide for controlling the seizures. ( Amamiya, S; Araki, A; Fujieda, K; Kajihama, A; Ohinata, J; Sugai, R; Suzuki, N; Takahashi, S; Tanaka, H, 2008)
"A 30-year-old woman with primary generalized tonic-clonic seizures and myoclonic jerks was taking zonisamide 200 mg daily as her sole antiepileptic agent when she conceived."7.74Zonisamide concentrations during pregnancy. ( Bell, WL; Oles, KS, 2008)
"We evaluated the anticonvulsive effects of phenobarbital (PB) and zonisamide (ZNS) in the EL mouse, a strain that is highly susceptible to seizures."7.69Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse. ( Akasaki, Y; Nagase, F; Nagatomo, I; Nomaguchi, M; Takigawa, M, 1996)
" Limbic seizure status epilepticus was induced by a unilateral microinjection of kainic acid (KA) into the amygdala."7.69Zonisamide: electrophysiological and metabolic changes in kainic acid-induced limbic seizures in rats. ( Fujita, T; Nakai, H; Takano, K; Tanaka, T; Yonemasu, Y, 1995)
"Seizure frequency (seizures/month; sz/m), blood tests including concentrations of ZNS and β-hydroxybutyric acid, and owner's visual analogue scale score were collected from all dogs for both treatment periods."7.30Efficacy evaluation of a commercially available MCT enriched therapeutic diet on dogs with idiopathic epilepsy treated with zonisamide: a prospective, randomized, double-blinded, placebo-controlled, crossover dietary preliminary study. ( Hasegawa, D; Nakatsuka, K; Zanghi, B, 2023)
" Treatment-emergent adverse events (AEs) were reported in 80 patients."6.77Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: a multicenter open-label single-arm trial in Korean patients. ( Cho, YW; Heo, K; Kim, KS; Kim, OJ; Kim, SE; Kim, SH; Lee, BI; Lee, JH; Lee, SJ; Park, SP; Shin, DJ; Song, HK; Yi, SD, 2012)
"A 56-day pharmacokinetic study of zonisamide was conducted in 24 healthy volunteers."6.69Steady-state pharmacokinetics of zonisamide, an antiepileptic agent for treatment of refractory complex partial seizures. ( Buchanan, RA; Kochak, GM; Padgett, CS; Page, JG; Peters, R, 1998)
"We examined seizure variables, medical comorbidities, and concomitant medications."5.46Tolerability of lacosamide or zonisamide in elderly patients with seizures. ( Lee, JW; Nicolas, J; Sarkis, RA, 2017)
"Minimal clonic seizures were not suppressed by zonisamide."5.36Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats. ( Mareš, P, 2010)
"During limbic status epilepticus, only seizures in the sensorimotor cortex were markedly attenuated a few minutes after 14C-ZNS administration."5.31Regional accumulation of 14C-zonisamide in rat brain during kainic acid-induced limbic seizures. ( Akaike, K; Fukumoto, S; Imamura, S; Takigawa, M; Tanaka, S; Tojo, H, 2001)
"Zonisamide treatment was generally well tolerated and was associated with significant reductions in seizure frequency in this pediatric population with a variety of both partial and generalized medically refractory epilepsy syndromes."5.14Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy. ( Conry, JA; Pellock, JM; Shinnar, S, 2009)
"To examine the safety and efficacy of zonisamide in treating myoclonic seizures associated with progressive myoclonic epilepsy (PME), in an open-label setting."5.13Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study. ( Conry, JA; Murphy, JV; Vossler, DG, 2008)
"Zonisamide is currently licensed in Europe and the USA for the adjunctive treatment of partial seizures (with or without secondary generalization) in adults, based on the results of four pivotal, randomized, double-blind, placebo-controlled trials."4.88Zonisamide in clinical practice. ( Dupont, S; Stefan, H, 2012)
"Based on these data, lacosamide and eslicarbazepine might be more favorable in the treatment of refractory status epilepticus in poststroke epilepsy, when administered as second- or third-line ASMs before anesthesia."4.31Third-Generation Antiseizure Medication in the Treatment of Benzodiazepine-Refractory Status Epilepticus in Poststroke Epilepsy: A Retrospective Observational Register-Based Study. ( Gonzalez-Escamilla, G; Groppa, S; Sandner, K; Stuckrad-Barre, SV; Vieth, T; Winter, Y, 2023)
"To assess the therapeutic efficacy and safety of antiseizure medication (ASM) for a minimum of 6 months, including zonisamide (ZNS), in feline idiopathic epilepsy at a referral hospital in Japan."4.31Evaluation of antiseizure medications including zonisamide in feline idiopathic epilepsy at a referral hospital in Japan. ( Maeda, S; Motegi, T; Yonezawa, T; Yoshida, S, 2023)
"To investigate caregivers' assessments of outcome in dogs with idiopathic epilepsy (IE) administered levetiracetam (LEV), zonisamide (ZNS), or phenobarbital (PB) monotherapy."4.31Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy. ( Gristina, BR; Muñana, KR; Nettifee, JA; Waldron, RJ, 2023)
"Zonisamide (ZNS) is a new generation antiepileptic drug (AED) used in refractory epilepsy."4.12Effectiveness of zonisamide in childhood refractory epilepsy. ( Aslan, M; Gungor, S, 2022)
"The present findings revealed that zonisamide treatment prevented the development of seizures in animals."3.88A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures. ( Attri, SV; Kumar, B; Medhi, B; Modi, M; Patial, A; Saikia, B, 2018)
" On referral, treatment with levetiracetam, zonisamide, and phenobarbital initially provided good control of cluster seizure activity (attributable to epilepsy of unknow origin)."3.85Suspected zonisamide-related anticonvulsant hypersensitivity syndrome in a cat. ( Collinet, A; Sammut, V, 2017)
"Zonisamide is licensed for adjunctive therapy for partial-onset seizures with or without secondary generalisation in patients 6 years and older and as monotherapy for the treatment of partial seizures in adult patients with newly diagnosed epilepsy, and shows a favourable pharmacokinetic profile with low interaction potential with other drugs."3.83Retention, dosing, tolerability and patient reported seizure outcome of Zonisamide as only add-on treatment under real-life conditions in adult patients with partial onset seizures: Results of the observational study ZOOM. ( Baulac, M; Hamer, H; Kockelmann, E; McMurray, R, 2016)
"This retrospective study examined the efficacy and safety of zonisamide for Thai children and adolescents with intractable seizures."3.81Efficacy and safety of zonisamide in Thai children and adolescents with intractable seizures. ( Khongkhatithum, C; Thampratankul, L; Visudtibhan, A, 2015)
"In everyday practice, zonisamide is principally used in association with other antiepileptic drugs for the treatment of focal epilepsy in adults."3.79Management and monitoring of patients treated with zonisamide: the OZONE study. ( Allaf, B; Biraben, A; Dupont, S; Lavernhe, G; Marquet, T, 2013)
" However, zonisamide- and carbamazepine-treated animals had IT values similar to those of controls, but only zonisamide significantly decreased absence seizure development."3.77Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model. ( Citraro, R; Constanti, A; De Fazio, S; De Sarro, G; Di Paola, ED; Perrota, I; Perrotta, I; Russo, E; Scicchitano, F, 2011)
"Concerning zonisamide (ZNS) therapy, data on sexual dysfunction are not available either in patients with epilepsy or in patients with brain tumor-related epilepsy."3.77Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on. ( Dinapoli, L; Jandolo, B; Maschio, M; Saveriano, F, 2011)
" In addition, carbamazepine, zonisamide, and topiramate were more effective in suppressing OB-kindled seizures."3.76The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. ( Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010)
"A 30-year-old woman with primary generalized tonic-clonic seizures and myoclonic jerks was taking zonisamide 200 mg daily as her sole antiepileptic agent when she conceived."3.74Zonisamide concentrations during pregnancy. ( Bell, WL; Oles, KS, 2008)
" Both the patients developed seizures of various types that have been successfully treated with zonisamide."3.74Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: a successful use of zonisamide for controlling the seizures. ( Amamiya, S; Araki, A; Fujieda, K; Kajihama, A; Ohinata, J; Sugai, R; Suzuki, N; Takahashi, S; Tanaka, H, 2008)
"Zonisamide is a broad-spectrum antiepilepsy drug approved in the United States for the adjunctive treatment of partial seizures in adults with epilepsy."3.73Use of zonisamide in pediatric patients. ( Brotherton, T; Santos, CC, 2005)
" Convulsive seizures in the EL mice given the various diets did not differ over 1-4 weeks, but convulsions in EL mice given the Zn-deficient diet for 4 weeks were more effectively suppressed by injection of zonisamide (ZNS) (75 mg/kg intraperitoneally) than in mice receiving high- or adequate-Zn diet for the same period."3.70Influence of dietary zinc on convulsive seizures and hippocampal NADPH diaphorase-positive neurons in seizure susceptible EL mouse. ( Akasaki, Y; Kuchiiwa, S; Nagatomo, I; Nakagawa, S; Takigawa, M; Uchida, M, 1998)
" Limbic seizure status epilepticus was induced by a unilateral microinjection of kainic acid (KA) into the amygdala."3.69Zonisamide: electrophysiological and metabolic changes in kainic acid-induced limbic seizures in rats. ( Fujita, T; Nakai, H; Takano, K; Tanaka, T; Yonemasu, Y, 1995)
"We evaluated the anticonvulsive effects of phenobarbital (PB) and zonisamide (ZNS) in the EL mouse, a strain that is highly susceptible to seizures."3.69Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse. ( Akasaki, Y; Nagase, F; Nagatomo, I; Nomaguchi, M; Takigawa, M, 1996)
"Seizure frequency (seizures/month; sz/m), blood tests including concentrations of ZNS and β-hydroxybutyric acid, and owner's visual analogue scale score were collected from all dogs for both treatment periods."3.30Efficacy evaluation of a commercially available MCT enriched therapeutic diet on dogs with idiopathic epilepsy treated with zonisamide: a prospective, randomized, double-blinded, placebo-controlled, crossover dietary preliminary study. ( Hasegawa, D; Nakatsuka, K; Zanghi, B, 2023)
" Treatment-emergent adverse events (AEs) were reported in 80 patients."2.77Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: a multicenter open-label single-arm trial in Korean patients. ( Cho, YW; Heo, K; Kim, KS; Kim, OJ; Kim, SE; Kim, SH; Lee, BI; Lee, JH; Lee, SJ; Park, SP; Shin, DJ; Song, HK; Yi, SD, 2012)
"A 56-day pharmacokinetic study of zonisamide was conducted in 24 healthy volunteers."2.69Steady-state pharmacokinetics of zonisamide, an antiepileptic agent for treatment of refractory complex partial seizures. ( Buchanan, RA; Kochak, GM; Padgett, CS; Page, JG; Peters, R, 1998)
"The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be between 15% to 20%; however, the risk of experiencing a seizure appears to vary from 3% to 92% over a five-year period."2.66Antiepileptic drugs as prophylaxis for postcraniotomy seizures. ( Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J, 2020)
"Zonisamide is effective against focal seizures in adults and children and, thus, a therapeutic option for such patients."2.61An evaluation of zonisamide, including its long-term efficacy, for the treatment of focal epilepsy. ( Ljung, H; Reimers, A, 2019)
"Postoperative seizures can precipitate the development of epilepsy; seizures are most likely to occur within the first month of cranial surgery."2.58Antiepileptic drugs as prophylaxis for postcraniotomy seizures. ( Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J, 2018)
"Data regarding antiepileptic drug use in RRT are limited and mostly consist of case reports limiting our proposed dosing recommendations."2.53Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016)
"The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be between 15% to 20%; however, the risk of experiencing a seizure may vary from 3% to 92% over a five-year period."2.52Antiepileptic drugs as prophylaxis for post-craniotomy seizures. ( Greenhalgh, J; Marson, AG; Weston, J, 2015)
"The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be 15% to 20%; however, the risk of experiencing a seizure may vary from 3% to 92% over a five-year period."2.49Antiepileptic drugs as prophylaxis for post-craniotomy seizures. ( Greenhalgh, J; Marson, AG; Pulman, J, 2013)
"Epilepsy is one of the most common neurological conditions in the elderly, and the incidence of de novo geriatric epilepsy is rising."2.49[Epilepsy in the elderly]. ( Lossius, MI; Markhus, R; Nakken, KO; Sætre, E, 2013)
"Overall, only 24% of the 759 reported seizures had an associated EEG correlate, indicating a high over-reporting rate, which occurred in 57% of patients."1.91How accurately do adult patients report their absence seizures? ( O'Sullivan, S; Pizarro, J; Walker, MC, 2023)
"Under lamotrigine, seizure aggravation was observed in 15 patients (two patients during levetiracetam, one patient during zonisamide, none during phenobarbital and valproic acid)."1.62Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy. ( Beier, CP; Gesche, J; Hjalgrim, H; Rubboli, G, 2021)
"The levetiracetam dosage was increased (150 mg/kg [68 mg/lb], PO, q 8 h), and zonisamide (20 mg/kg [9."1.56Diagnosis and long-term management of post-traumatic seizures in a white-crowned pionus ( ( Beaufrère, H; Brouwer, E; James, F; Kabakchiev, C; Laniesse, D; Zur Linden, A, 2020)
"In five cases, tonic seizures preceded spasms at a median age of 6 weeks."1.51New insights in phenomenology and treatment of epilepsy in CDKL5 encephalopathy. ( Bienvenu, T; Chikvinidze, G; Dulac, O; Epitashvili, N; Gataullina, S; Melikishvili, G; Tabatadze, N, 2019)
"Best seizure control was achieved in patients with poststroke epilepsy; seizure freedom was 80% in this subgroup."1.46Efficacy, tolerability, and retention rates of zonisamide in older adult patients with focal-onset epilepsy: Experiences from two tertiary epilepsy centers. ( Doğan, EA; Erdoğan, Ç; Genç, BO; Genç, E, 2017)
"We examined seizure variables, medical comorbidities, and concomitant medications."1.46Tolerability of lacosamide or zonisamide in elderly patients with seizures. ( Lee, JW; Nicolas, J; Sarkis, RA, 2017)
"Lacosamide decreases seizure burden by modulating sodium channels."1.42Lacosamide-induced atrial tachycardia in a child with hypoplastic left-heart syndrome: the importance of assessing additional proarrhythmic risks. ( Gudausky, TM; Kovach, J; Loomba, RS; Singh, AK, 2015)
"Epileptic myoclonus is generally treated by valproate monotherapy, and this therapy has confirmed efficacy."1.38Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks. ( Arai, H; Iimura, Y; Nakajima, M; Sugano, H, 2012)
"Minimal clonic seizures were not suppressed by zonisamide."1.36Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats. ( Mareš, P, 2010)
" For patients undergoing daytime hemodialysis sessions every 2 or 3 days, the usual dosage of ZNS (4-8 mg/kg/day) may be prescribed once a day in the evening."1.32Dialyzability of the antiepileptic drug zonisamide in patients undergoing hemodialysis. ( Fukuda, F; Ijiri, Y; Inoue, T; Kobayashi, T; Shibahara, N; Suzuki, K; Takenaka, H; Tanaka, K, 2004)
"During limbic status epilepticus, only seizures in the sensorimotor cortex were markedly attenuated a few minutes after 14C-ZNS administration."1.31Regional accumulation of 14C-zonisamide in rat brain during kainic acid-induced limbic seizures. ( Akaike, K; Fukumoto, S; Imamura, S; Takigawa, M; Tanaka, S; Tojo, H, 2001)
"In the maximal electroshock seizure test, orally at 2 h in mice, 1 had an ED50 of 39 mg/kg."1.27Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate and related compounds. ( Dodgson, SP; Gardocki, JF; Maryanoff, BE; Nortey, SO; Shank, RP, 1987)

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-19903 (4.62)18.7374
1990's6 (9.23)18.2507
2000's17 (26.15)29.6817
2010's28 (43.08)24.3611
2020's11 (16.92)2.80

Authors

AuthorsStudies
Maryanoff, BE1
Nortey, SO1
Gardocki, JF1
Shank, RP1
Dodgson, SP1
Masereel, B1
Rolin, S1
Abbate, F1
Scozzafava, A1
Supuran, CT1
Shimshoni, JA1
Bialer, M1
Yagen, B1
Tanaka, T2
Yajima, N1
Tanitame, A1
Kiyoshi, T1
Miura, Y1
Aslan, M1
Gungor, S1
Pizarro, J1
O'Sullivan, S1
Walker, MC1
Gristina, BR1
Waldron, RJ1
Nettifee, JA1
Muñana, KR1
Yoshida, S1
Maeda, S1
Yonezawa, T1
Motegi, T1
Nakatsuka, K1
Zanghi, B1
Hasegawa, D1
Winter, Y1
Sandner, K1
Vieth, T1
Gonzalez-Escamilla, G1
Stuckrad-Barre, SV1
Groppa, S1
Fox, J1
Ajinkya, S1
Lekoubou, A1
Takami, Y1
Izawa, T1
Tanaka, M1
Hatoya, S1
Nabetani, T1
Yamate, J1
Kuwamura, M1
Greenhalgh, J4
Weston, J3
Dundar, Y2
Nevitt, SJ2
Marson, AG4
Kabakchiev, C1
Laniesse, D1
James, F1
Zur Linden, A1
Brouwer, E1
Beaufrère, H1
Gesche, J1
Hjalgrim, H1
Rubboli, G1
Beier, CP1
Sarkis, RA1
Nicolas, J1
Lee, JW1
Doğan, EA1
Genç, E1
Genç, BO1
Erdoğan, Ç1
Collinet, A1
Sammut, V1
Kumar, B1
Medhi, B1
Modi, M1
Saikia, B1
Attri, SV1
Patial, A1
Kim, KH1
Song, JS1
Park, CW1
Ki, CS1
Heo, K2
Wiencek, JR1
Dietzen, DJ1
Murray, T1
Dawling, S1
Colby, JM1
Nichols, JH1
Park, KM1
Lee, BI2
Shin, KJ1
Ha, SY1
Park, J1
Kim, SE3
Melikishvili, G1
Epitashvili, N1
Tabatadze, N1
Chikvinidze, G1
Dulac, O1
Bienvenu, T1
Gataullina, S1
Reimers, A1
Ljung, H1
Tombini, M1
Pellegrino, G1
Di Pino, G1
Assenza, G1
Pulman, J1
Nakken, KO1
Sætre, E1
Markhus, R1
Lossius, MI1
Dupont, S2
Biraben, A1
Lavernhe, G1
Marquet, T1
Allaf, B1
Loomba, RS1
Singh, AK1
Kovach, J1
Gudausky, TM1
Thampratankul, L1
Khongkhatithum, C1
Visudtibhan, A1
Janszky, J1
Horvath, R1
Komoly, S1
Hamer, H1
Baulac, M1
McMurray, R1
Kockelmann, E1
Smetana, KS1
Cook, AM1
Bastin, ML1
Oyler, DR1
Oles, KS1
Bell, WL1
Maschio, M1
Saveriano, F1
Dinapoli, L1
Jandolo, B1
Shaikh, AY1
Muranjan, MN1
Gogtay, NJ1
Lahiri, KR1
Fujiwara, A1
Watanabe, Y1
Takechi, K1
Ishikawa, T1
Kaida, Y1
Akagi, M1
Kamei, C2
Mareš, P1
Russo, E1
Citraro, R1
Scicchitano, F1
De Fazio, S1
Perrotta, I1
Perrota, I1
Di Paola, ED1
Constanti, A1
De Sarro, G1
Iimura, Y1
Sugano, H1
Nakajima, M1
Arai, H1
Yi, SD1
Cho, YW1
Shin, DJ1
Song, HK2
Kim, OJ1
Park, SP1
Kim, SH1
Lee, JH1
Kim, KS1
Lee, SJ1
Stefan, H1
Hashimoto, Y1
Araki, H1
Futagami, K1
Kawasaki, H1
Gomita, Y1
Ijiri, Y1
Inoue, T1
Fukuda, F1
Suzuki, K1
Kobayashi, T1
Shibahara, N1
Takenaka, H1
Tanaka, K1
Santos, CC1
Brotherton, T1
Kwak, SE1
Kim, JE1
Kim, DS1
Won, MH1
Choi, HC1
Kim, YI1
Choi, SY1
Kang, TC1
Willmore, LJ1
Ueda, Y1
Doi, T1
Tokumaru, J1
Nakajima, A1
Nagatomo, K1
Masumizu, T1
Noda, Y1
Mori, A1
Packer, L1
Davenport, RD1
Patel, NC1
Shinnar, S1
Pellock, JM1
Conry, JA2
Vossler, DG1
Murphy, JV1
Takahashi, S1
Ohinata, J1
Suzuki, N1
Amamiya, S1
Kajihama, A1
Sugai, R2
Araki, A1
Fujieda, K1
Tanaka, H1
Oka, M1
Masuda, Y3
Yoshida, K2
Shimizu, M2
Karasawa, T2
Shiraishi, Y1
Hori, M1
Takano, K1
Fujita, T1
Nakai, H1
Yonemasu, Y1
Noguchi, H1
Kaneko, S1
Okada, M1
Hirano, T1
Kondo, T1
Otani, K1
Fukushima, Y1
Nagatomo, I2
Akasaki, Y2
Nagase, F1
Nomaguchi, M1
Takigawa, M3
Kochak, GM1
Page, JG1
Buchanan, RA1
Peters, R1
Padgett, CS1
Uchida, M1
Kuchiiwa, S1
Nakagawa, S1
Miyamoto, A1
Okamoto, T1
Shirai, M1
Oki, J1
Akaike, K1
Tanaka, S1
Tojo, H1
Fukumoto, S1
Imamura, S1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Study of Pharmacokinetics of Levetiracetam in Patients Undergoing Intermittent Hemodialysis[NCT04511676]12 participants (Actual)Observational2018-11-01Completed
Clinical Cohort Study of Association Between Steady State Phenytoin Treatment and Better Clinical Parameters of Glaucoma[NCT00739154]200 participants (Anticipated)Observational2008-11-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for zonisamide and Seizures

ArticleYear
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
    The Cochrane database of systematic reviews, 2020, 04-28, Volume: 4

    Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt

2020
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
    The Cochrane database of systematic reviews, 2020, 04-28, Volume: 4

    Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt

2020
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
    The Cochrane database of systematic reviews, 2018, 05-23, Volume: 5

    Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt

2018
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
    The Cochrane database of systematic reviews, 2018, 05-23, Volume: 5

    Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt

2018
An evaluation of zonisamide, including its long-term efficacy, for the treatment of focal epilepsy.
    Expert opinion on pharmacotherapy, 2019, Volume: 20, Issue:8

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Generalized; Humans; Se

2019
An evaluation of zonisamide, including its long-term efficacy, for the treatment of focal epilepsy.
    Expert opinion on pharmacotherapy, 2019, Volume: 20, Issue:8

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Generalized; Humans; Se

2019
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
    The Cochrane database of systematic reviews, 2013, Feb-28, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized

2013
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
    The Cochrane database of systematic reviews, 2013, Feb-28, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized

2013
[Epilepsy in the elderly].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2013, Mar-05, Volume: 133, Issue:5

    Topics: Age Factors; Aged; Aging; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Isoxa

2013
[Epilepsy in the elderly].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2013, Mar-05, Volume: 133, Issue:5

    Topics: Age Factors; Aged; Aging; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Isoxa

2013
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
    The Cochrane database of systematic reviews, 2015, Mar-04, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized

2015
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
    The Cochrane database of systematic reviews, 2015, Mar-04, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized

2015
[ZONISAMIDE: FIRST CHOICE AMONG THE FIRST-LINE ANTIEPILEPTIC DRUGS IN FOCAL EPILEPSY].
    Ideggyogyaszati szemle, 2015, May-30, Volume: 68, Issue:5-6

    Topics: Adolescent; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Administratio

2015
[ZONISAMIDE: FIRST CHOICE AMONG THE FIRST-LINE ANTIEPILEPTIC DRUGS IN FOCAL EPILEPSY].
    Ideggyogyaszati szemle, 2015, May-30, Volume: 68, Issue:5-6

    Topics: Adolescent; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Administratio

2015
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
    Journal of critical care, 2016, Volume: 36

    Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanec

2016
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
    Journal of critical care, 2016, Volume: 36

    Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanec

2016
Zonisamide in clinical practice.
    Acta neurologica Scandinavica. Supplementum, 2012, Issue:194

    Topics: Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; Quality of Life; Seizures; Treatment Outco

2012
Zonisamide in clinical practice.
    Acta neurologica Scandinavica. Supplementum, 2012, Issue:194

    Topics: Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; Quality of Life; Seizures; Treatment Outco

2012
Antiepileptic drugs and neuroprotection: current status and future roles.
    Epilepsy & behavior : E&B, 2005, Volume: 7 Suppl 3

    Topics: Animals; Anticonvulsants; Brain; Epilepsy; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam;

2005
Antiepileptic drugs and neuroprotection: current status and future roles.
    Epilepsy & behavior : E&B, 2005, Volume: 7 Suppl 3

    Topics: Animals; Anticonvulsants; Brain; Epilepsy; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam;

2005

Trials

5 trials available for zonisamide and Seizures

ArticleYear
Efficacy evaluation of a commercially available MCT enriched therapeutic diet on dogs with idiopathic epilepsy treated with zonisamide: a prospective, randomized, double-blinded, placebo-controlled, crossover dietary preliminary study.
    BMC veterinary research, 2023, Sep-06, Volume: 19, Issue:1

    Topics: Animals; Diet; Dog Diseases; Dogs; Epilepsy; Prospective Studies; Seizures; Triglycerides; Zonisamid

2023
Efficacy evaluation of a commercially available MCT enriched therapeutic diet on dogs with idiopathic epilepsy treated with zonisamide: a prospective, randomized, double-blinded, placebo-controlled, crossover dietary preliminary study.
    BMC veterinary research, 2023, Sep-06, Volume: 19, Issue:1

    Topics: Animals; Diet; Dog Diseases; Dogs; Epilepsy; Prospective Studies; Seizures; Triglycerides; Zonisamid

2023
Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: a multicenter open-label single-arm trial in Korean patients.
    Seizure, 2012, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsies, Partial; Fem

2012
Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: a multicenter open-label single-arm trial in Korean patients.
    Seizure, 2012, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsies, Partial; Fem

2012
Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Adminis

2009
Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Adminis

2009
Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study.
    Epileptic disorders : international epilepsy journal with videotape, 2008, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Female; Humans; Isoxazoles; Male; Myocl

2008
Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study.
    Epileptic disorders : international epilepsy journal with videotape, 2008, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Female; Humans; Isoxazoles; Male; Myocl

2008
Steady-state pharmacokinetics of zonisamide, an antiepileptic agent for treatment of refractory complex partial seizures.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:2

    Topics: Anticonvulsants; Half-Life; Humans; Isoxazoles; Metabolic Clearance Rate; Seizures; Zonisamide

1998
Steady-state pharmacokinetics of zonisamide, an antiepileptic agent for treatment of refractory complex partial seizures.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:2

    Topics: Anticonvulsants; Half-Life; Humans; Isoxazoles; Metabolic Clearance Rate; Seizures; Zonisamide

1998

Other Studies

50 other studies available for zonisamide and Seizures

ArticleYear
Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate and related compounds.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:5

    Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Electroshock; Fructose; Kinet

1987
Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate and related compounds.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:5

    Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Electroshock; Fructose; Kinet

1987
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.
    Journal of medicinal chemistry, 2002, Jan-17, Volume: 45, Issue:2

    Topics: Acetazolamide; Animals; Anticonvulsants; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhyd

2002
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.
    Journal of medicinal chemistry, 2002, Jan-17, Volume: 45, Issue:2

    Topics: Acetazolamide; Animals; Anticonvulsants; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhyd

2002
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mic

2008
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mic

2008
Discovery of benzothiazine derivatives as novel, orally-active anti-epileptic drug candidates with broad anticonvulsant effect.
    Bioorganic & medicinal chemistry letters, 2015, Oct-15, Volume: 25, Issue:20

    Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship,

2015
Discovery of benzothiazine derivatives as novel, orally-active anti-epileptic drug candidates with broad anticonvulsant effect.
    Bioorganic & medicinal chemistry letters, 2015, Oct-15, Volume: 25, Issue:20

    Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship,

2015
Effectiveness of zonisamide in childhood refractory epilepsy.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2022, Volume: 38, Issue:5

    Topics: Child; Drug Resistant Epilepsy; Epilepsies, Partial; Epilepsy; Humans; Reproducibility of Results; R

2022
Effectiveness of zonisamide in childhood refractory epilepsy.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2022, Volume: 38, Issue:5

    Topics: Child; Drug Resistant Epilepsy; Epilepsies, Partial; Epilepsy; Humans; Reproducibility of Results; R

2022
How accurately do adult patients report their absence seizures?
    Epilepsia open, 2023, Volume: 8, Issue:2

    Topics: Adult; Epilepsy, Absence; Female; Humans; Inpatients; Male; Seizures; Valproic Acid; Zonisamide

2023
How accurately do adult patients report their absence seizures?
    Epilepsia open, 2023, Volume: 8, Issue:2

    Topics: Adult; Epilepsy, Absence; Female; Humans; Inpatients; Male; Seizures; Valproic Acid; Zonisamide

2023
Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy.
    Journal of the American Veterinary Medical Association, 2023, 07-01, Volume: 261, Issue:7

    Topics: Animals; Anticonvulsants; Caregivers; Dog Diseases; Dogs; Epilepsy; Humans; Levetiracetam; Phenobarb

2023
Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy.
    Journal of the American Veterinary Medical Association, 2023, 07-01, Volume: 261, Issue:7

    Topics: Animals; Anticonvulsants; Caregivers; Dog Diseases; Dogs; Epilepsy; Humans; Levetiracetam; Phenobarb

2023
Evaluation of antiseizure medications including zonisamide in feline idiopathic epilepsy at a referral hospital in Japan.
    Open veterinary journal, 2023, Volume: 13, Issue:7

    Topics: Animals; Cat Diseases; Cats; Epilepsy; Hospitals; Japan; Referral and Consultation; Retrospective St

2023
Evaluation of antiseizure medications including zonisamide in feline idiopathic epilepsy at a referral hospital in Japan.
    Open veterinary journal, 2023, Volume: 13, Issue:7

    Topics: Animals; Cat Diseases; Cats; Epilepsy; Hospitals; Japan; Referral and Consultation; Retrospective St

2023
Third-Generation Antiseizure Medication in the Treatment of Benzodiazepine-Refractory Status Epilepticus in Poststroke Epilepsy: A Retrospective Observational Register-Based Study.
    CNS drugs, 2023, Volume: 37, Issue:10

    Topics: Aged; Anticonvulsants; Benzodiazepines; Epilepsy; Humans; Ischemic Stroke; Lacosamide; Middle Aged;

2023
Third-Generation Antiseizure Medication in the Treatment of Benzodiazepine-Refractory Status Epilepticus in Poststroke Epilepsy: A Retrospective Observational Register-Based Study.
    CNS drugs, 2023, Volume: 37, Issue:10

    Topics: Aged; Anticonvulsants; Benzodiazepines; Epilepsy; Humans; Ischemic Stroke; Lacosamide; Middle Aged;

2023
Patterns of antiepileptic drug use among elderly patients with epilepsy: 2004-2015.
    Epilepsy research, 2020, Volume: 161

    Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; F

2020
Patterns of antiepileptic drug use among elderly patients with epilepsy: 2004-2015.
    Epilepsy research, 2020, Volume: 161

    Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; F

2020
Hepatocellular necrosis with prominent regenerative reactions in a zonisamide administrated dog.
    The Journal of veterinary medical science, 2020, Jun-16, Volume: 82, Issue:6

    Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Liver; Liver R

2020
Hepatocellular necrosis with prominent regenerative reactions in a zonisamide administrated dog.
    The Journal of veterinary medical science, 2020, Jun-16, Volume: 82, Issue:6

    Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Liver; Liver R

2020
Diagnosis and long-term management of post-traumatic seizures in a white-crowned pionus (
    Journal of the American Veterinary Medical Association, 2020, May-15, Volume: 256, Issue:10

    Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Female; Levetiracetam; Parrots; Seizures; Zonis

2020
Diagnosis and long-term management of post-traumatic seizures in a white-crowned pionus (
    Journal of the American Veterinary Medical Association, 2020, May-15, Volume: 256, Issue:10

    Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Female; Levetiracetam; Parrots; Seizures; Zonis

2020
Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.
    Epilepsy research, 2021, Volume: 170

    Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Humans; Lamotrigine; Levetiracetam; Myoclonic Epileps

2021
Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.
    Epilepsy research, 2021, Volume: 170

    Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Humans; Lamotrigine; Levetiracetam; Myoclonic Epileps

2021
Tolerability of lacosamide or zonisamide in elderly patients with seizures.
    Seizure, 2017, Volume: 49

    Topics: Acetamides; Aged; Anticonvulsants; Dizziness; Female; Gait; Humans; Isoxazoles; Lacosamide; Male; Po

2017
Tolerability of lacosamide or zonisamide in elderly patients with seizures.
    Seizure, 2017, Volume: 49

    Topics: Acetamides; Aged; Anticonvulsants; Dizziness; Female; Gait; Humans; Isoxazoles; Lacosamide; Male; Po

2017
Efficacy, tolerability, and retention rates of zonisamide in older adult patients with focal-onset epilepsy: Experiences from two tertiary epilepsy centers.
    Epilepsy & behavior : E&B, 2017, Volume: 76

    Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Tolerance; Epilepsies, Partial; Female; Huma

2017
Efficacy, tolerability, and retention rates of zonisamide in older adult patients with focal-onset epilepsy: Experiences from two tertiary epilepsy centers.
    Epilepsy & behavior : E&B, 2017, Volume: 76

    Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Tolerance; Epilepsies, Partial; Female; Huma

2017
Suspected zonisamide-related anticonvulsant hypersensitivity syndrome in a cat.
    Journal of the American Veterinary Medical Association, 2017, Dec-15, Volume: 251, Issue:12

    Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Diagnosis, Differential; Drug Hypersensitivity; Epilep

2017
Suspected zonisamide-related anticonvulsant hypersensitivity syndrome in a cat.
    Journal of the American Veterinary Medical Association, 2017, Dec-15, Volume: 251, Issue:12

    Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Diagnosis, Differential; Drug Hypersensitivity; Epilep

2017
A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures.
    Inflammopharmacology, 2018, Volume: 26, Issue:4

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Free Radicals; Inflammatio

2018
A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures.
    Inflammopharmacology, 2018, Volume: 26, Issue:4

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Free Radicals; Inflammatio

2018
First Molecular Diagnosis of a Patient with Unverricht-Lundborg Disease in Korea.
    Yonsei medical journal, 2018, Volume: 59, Issue:6

    Topics: Adult; Anticonvulsants; Blotting, Southern; Cystatin B; Female; Genetic Predisposition to Disease; H

2018
First Molecular Diagnosis of a Patient with Unverricht-Lundborg Disease in Korea.
    Yonsei medical journal, 2018, Volume: 59, Issue:6

    Topics: Adult; Anticonvulsants; Blotting, Southern; Cystatin B; Female; Genetic Predisposition to Disease; H

2018
Persistently Increased Alloisoleucine in a Patient with Seizures.
    Clinical chemistry, 2018, Volume: 64, Issue:10

    Topics: Anticonvulsants; Blood Chemical Analysis; Child, Preschool; Diagnosis, Differential; Female; Humans;

2018
Persistently Increased Alloisoleucine in a Patient with Seizures.
    Clinical chemistry, 2018, Volume: 64, Issue:10

    Topics: Anticonvulsants; Blood Chemical Analysis; Child, Preschool; Diagnosis, Differential; Female; Humans;

2018
Efficacy, tolerability, and blood concentration of zonisamide in daily clinical practice.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2019, Volume: 61

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Middle Aged; Retrospective Studi

2019
Efficacy, tolerability, and blood concentration of zonisamide in daily clinical practice.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2019, Volume: 61

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Middle Aged; Retrospective Studi

2019
New insights in phenomenology and treatment of epilepsy in CDKL5 encephalopathy.
    Epilepsy & behavior : E&B, 2019, Volume: 94

    Topics: Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Electro

2019
New insights in phenomenology and treatment of epilepsy in CDKL5 encephalopathy.
    Epilepsy & behavior : E&B, 2019, Volume: 94

    Topics: Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Electro

2019
Zonisamide for seizures in Parkinson's disease with dementia.
    Seizure, 2013, Volume: 22, Issue:4

    Topics: Aged; Anticonvulsants; Dementia; Humans; Isoxazoles; Male; Parkinson Disease; Seizures; Zonisamide

2013
Zonisamide for seizures in Parkinson's disease with dementia.
    Seizure, 2013, Volume: 22, Issue:4

    Topics: Aged; Anticonvulsants; Dementia; Humans; Isoxazoles; Male; Parkinson Disease; Seizures; Zonisamide

2013
Management and monitoring of patients treated with zonisamide: the OZONE study.
    Epileptic disorders : international epilepsy journal with videotape, 2013, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Data Collection; Data Interpretation, S

2013
Management and monitoring of patients treated with zonisamide: the OZONE study.
    Epileptic disorders : international epilepsy journal with videotape, 2013, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Data Collection; Data Interpretation, S

2013
Lacosamide-induced atrial tachycardia in a child with hypoplastic left-heart syndrome: the importance of assessing additional proarrhythmic risks.
    Cardiology in the young, 2015, Volume: 25, Issue:4

    Topics: Acetamides; Anticonvulsants; Arrhythmias, Cardiac; Child, Preschool; Comorbidity; Humans; Hypoplasti

2015
Lacosamide-induced atrial tachycardia in a child with hypoplastic left-heart syndrome: the importance of assessing additional proarrhythmic risks.
    Cardiology in the young, 2015, Volume: 25, Issue:4

    Topics: Acetamides; Anticonvulsants; Arrhythmias, Cardiac; Child, Preschool; Comorbidity; Humans; Hypoplasti

2015
Efficacy and safety of zonisamide in Thai children and adolescents with intractable seizures.
    Journal of child neurology, 2015, Volume: 30, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Isoxazoles; Male; Retrospectiv

2015
Efficacy and safety of zonisamide in Thai children and adolescents with intractable seizures.
    Journal of child neurology, 2015, Volume: 30, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Isoxazoles; Male; Retrospectiv

2015
Retention, dosing, tolerability and patient reported seizure outcome of Zonisamide as only add-on treatment under real-life conditions in adult patients with partial onset seizures: Results of the observational study ZOOM.
    Seizure, 2016, Volume: 34

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Therapy, Combination; Drug Toleran

2016
Retention, dosing, tolerability and patient reported seizure outcome of Zonisamide as only add-on treatment under real-life conditions in adult patients with partial onset seizures: Results of the observational study ZOOM.
    Seizure, 2016, Volume: 34

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Therapy, Combination; Drug Toleran

2016
Zonisamide concentrations during pregnancy.
    The Annals of pharmacotherapy, 2008, Volume: 42, Issue:7

    Topics: Adult; Anticonvulsants; Female; Humans; Isoxazoles; Myoclonic Epilepsy, Juvenile; Pregnancy; Pregnan

2008
Zonisamide concentrations during pregnancy.
    The Annals of pharmacotherapy, 2008, Volume: 42, Issue:7

    Topics: Adult; Anticonvulsants; Female; Humans; Isoxazoles; Myoclonic Epilepsy, Juvenile; Pregnancy; Pregnan

2008
Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on.
    The journal of sexual medicine, 2011, Volume: 8, Issue:12

    Topics: Adult; Anticonvulsants; Astrocytoma; Brain Neoplasms; Epilepsy; Erectile Dysfunction; Humans; Isoxaz

2011
Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on.
    The journal of sexual medicine, 2011, Volume: 8, Issue:12

    Topics: Adult; Anticonvulsants; Astrocytoma; Brain Neoplasms; Epilepsy; Erectile Dysfunction; Humans; Isoxaz

2011
Possible mechanism for zonisamide-induced hyperammonemia in a child with citrullinemia type 1.
    Indian journal of medical sciences, 2009, Volume: 63, Issue:5

    Topics: Anticonvulsants; Child; Citrullinemia; Humans; Hyperammonemia; Isoxazoles; Male; Seizures; Zonisamid

2009
Possible mechanism for zonisamide-induced hyperammonemia in a child with citrullinemia type 1.
    Indian journal of medical sciences, 2009, Volume: 63, Issue:5

    Topics: Anticonvulsants; Child; Citrullinemia; Humans; Hyperammonemia; Isoxazoles; Male; Seizures; Zonisamid

2009
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electri

2010
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electri

2010
Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats.
    Epilepsy research, 2010, Volume: 92, Issue:2-3

    Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Incidence; Isoxazoles; Male; Rat

2010
Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats.
    Epilepsy research, 2010, Volume: 92, Issue:2-3

    Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Incidence; Isoxazoles; Male; Rat

2010
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.
    Epilepsia, 2011, Volume: 52, Issue:7

    Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Depression; Dose-Response Relationship, Drug; Electr

2011
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.
    Epilepsia, 2011, Volume: 52, Issue:7

    Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Depression; Dose-Response Relationship, Drug; Electr

2011
Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks.
    World neurosurgery, 2012, Volume: 77, Issue:2

    Topics: Anticonvulsants; Cognition Disorders; Corpus Callosum; Cortical Synchronization; Drug Resistance; El

2012
Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks.
    World neurosurgery, 2012, Volume: 77, Issue:2

    Topics: Anticonvulsants; Cognition Disorders; Corpus Callosum; Cortical Synchronization; Drug Resistance; El

2012
Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl.
    Physiology & behavior, 2003, Volume: 78, Issue:3

    Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Epilepsy, Tonic-Clonic; Flurothyl; Isoxazoles; Ki

2003
Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl.
    Physiology & behavior, 2003, Volume: 78, Issue:3

    Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Epilepsy, Tonic-Clonic; Flurothyl; Isoxazoles; Ki

2003
Dialyzability of the antiepileptic drug zonisamide in patients undergoing hemodialysis.
    Epilepsia, 2004, Volume: 45, Issue:8

    Topics: Adult; Anticonvulsants; Anuria; Comorbidity; Drug Administration Schedule; Female; Hemodialysis Solu

2004
Dialyzability of the antiepileptic drug zonisamide in patients undergoing hemodialysis.
    Epilepsia, 2004, Volume: 45, Issue:8

    Topics: Adult; Anticonvulsants; Anuria; Comorbidity; Drug Administration Schedule; Female; Hemodialysis Solu

2004
Use of zonisamide in pediatric patients.
    Pediatric neurology, 2005, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Huma

2005
Use of zonisamide in pediatric patients.
    Pediatric neurology, 2005, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Huma

2005
Differential effects of vigabatrin and zonisamide on the neuropeptide Y system in the hippocampus of seizure prone gerbil.
    Neuropeptides, 2005, Volume: 39, Issue:5

    Topics: Animals; Anticonvulsants; Gerbillinae; Hippocampus; In Situ Hybridization; Isoxazoles; Neuropeptide

2005
Differential effects of vigabatrin and zonisamide on the neuropeptide Y system in the hippocampus of seizure prone gerbil.
    Neuropeptides, 2005, Volume: 39, Issue:5

    Topics: Animals; Anticonvulsants; Gerbillinae; Hippocampus; In Situ Hybridization; Isoxazoles; Neuropeptide

2005
In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in rats.
    Neurochemical research, 2005, Volume: 30, Issue:9

    Topics: Animals; Anticonvulsants; Electron Spin Resonance Spectroscopy; Hippocampus; Isoxazoles; Kainic Acid

2005
In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in rats.
    Neurochemical research, 2005, Volume: 30, Issue:9

    Topics: Animals; Anticonvulsants; Electron Spin Resonance Spectroscopy; Hippocampus; Isoxazoles; Kainic Acid

2005
Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures.
    Brain research. Brain research protocols, 2005, Volume: 16, Issue:1-3

    Topics: Animals; Anticonvulsants; Ascorbic Acid; Electron Spin Resonance Spectroscopy; Epilepsy, Tonic-Cloni

2005
Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures.
    Brain research. Brain research protocols, 2005, Volume: 16, Issue:1-3

    Topics: Animals; Anticonvulsants; Ascorbic Acid; Electron Spin Resonance Spectroscopy; Epilepsy, Tonic-Cloni

2005
Zonisamide as treatment for seizures.
    The Nurse practitioner, 2007, Volume: 32, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Isoxazoles; Seizures; Zonisamide

2007
Zonisamide as treatment for seizures.
    The Nurse practitioner, 2007, Volume: 32, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Isoxazoles; Seizures; Zonisamide

2007
Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: a successful use of zonisamide for controlling the seizures.
    Epilepsy research, 2008, Volume: 80, Issue:1

    Topics: Anticonvulsants; Biological Transport; Child; DNA Mutational Analysis; Erythrocytes; Female; Glucose

2008
Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: a successful use of zonisamide for controlling the seizures.
    Epilepsy research, 2008, Volume: 80, Issue:1

    Topics: Anticonvulsants; Biological Transport; Child; DNA Mutational Analysis; Erythrocytes; Female; Glucose

2008
Effects of 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810) and some antiepileptics on the kindled seizures in the neocortex, hippocampus and amygdala in rats.
    Archives internationales de pharmacodynamie et de therapie, 1981, Volume: 249, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electroencephalography; H

1981
Effects of 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810) and some antiepileptics on the kindled seizures in the neocortex, hippocampus and amygdala in rats.
    Archives internationales de pharmacodynamie et de therapie, 1981, Volume: 249, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electroencephalography; H

1981
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Pharmacological profile.
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:3

    Topics: Animals; Anticonvulsants; Barbiturates; Carbonic Anhydrase Inhibitors; Dogs; Electroshock; Isoxazole

1980
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Pharmacological profile.
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:3

    Topics: Animals; Anticonvulsants; Barbiturates; Carbonic Anhydrase Inhibitors; Dogs; Electroshock; Isoxazole

1980
Zonisamide: electrophysiological and metabolic changes in kainic acid-induced limbic seizures in rats.
    Epilepsia, 1995, Volume: 36, Issue:7

    Topics: Animals; Anticonvulsants; Autoradiography; Brain; Electroencephalography; Glucose; Isoxazoles; Kaini

1995
Zonisamide: electrophysiological and metabolic changes in kainic acid-induced limbic seizures in rats.
    Epilepsia, 1995, Volume: 36, Issue:7

    Topics: Animals; Anticonvulsants; Autoradiography; Brain; Electroencephalography; Glucose; Isoxazoles; Kaini

1995
Evidence against a significant implication of carbonic anhydrase inhibitory activity of zonisamide in its anticonvulsive effects.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Carbonic Anhydrase Inhibitors; Electroshock; In Vitro Techniques; I

1994
Evidence against a significant implication of carbonic anhydrase inhibitory activity of zonisamide in its anticonvulsive effects.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Carbonic Anhydrase Inhibitors; Electroshock; In Vitro Techniques; I

1994
Carbamazepine and zonisamide increase extracellular dopamine and serotonin levels in vivo, and carbamazepine does not antagonize adenosine effect in vitro: mechanisms of blockade of seizure spread.
    The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2

    Topics: Adenosine; Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Culture Techniques; Dopamine;

1993
Carbamazepine and zonisamide increase extracellular dopamine and serotonin levels in vivo, and carbamazepine does not antagonize adenosine effect in vitro: mechanisms of blockade of seizure spread.
    The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2

    Topics: Adenosine; Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Culture Techniques; Dopamine;

1993
Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse.
    Brain research, 1996, Aug-26, Volume: 731, Issue:1-2

    Topics: Animals; Anticonvulsants; Brain Chemistry; Dose-Response Relationship, Drug; Drug Interactions; Fema

1996
Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse.
    Brain research, 1996, Aug-26, Volume: 731, Issue:1-2

    Topics: Animals; Anticonvulsants; Brain Chemistry; Dose-Response Relationship, Drug; Drug Interactions; Fema

1996
Influence of dietary zinc on convulsive seizures and hippocampal NADPH diaphorase-positive neurons in seizure susceptible EL mouse.
    Brain research, 1998, Apr-13, Volume: 789, Issue:2

    Topics: Animals; Anticonvulsants; Cell Count; Diet; Genetic Predisposition to Disease; Hippocampus; Isoxazol

1998
Influence of dietary zinc on convulsive seizures and hippocampal NADPH diaphorase-positive neurons in seizure susceptible EL mouse.
    Brain research, 1998, Apr-13, Volume: 789, Issue:2

    Topics: Animals; Anticonvulsants; Cell Count; Diet; Genetic Predisposition to Disease; Hippocampus; Isoxazol

1998
Urine stone formation during treatment with zonisamide.
    Brain & development, 2000, Volume: 22, Issue:7

    Topics: Anticonvulsants; Child; Encephalitis, Viral; Epstein-Barr Virus Infections; Female; Hematuria; Herpe

2000
Urine stone formation during treatment with zonisamide.
    Brain & development, 2000, Volume: 22, Issue:7

    Topics: Anticonvulsants; Child; Encephalitis, Viral; Epstein-Barr Virus Infections; Female; Hematuria; Herpe

2000
Regional accumulation of 14C-zonisamide in rat brain during kainic acid-induced limbic seizures.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2001, Volume: 28, Issue:4

    Topics: Animals; Anticonvulsants; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Injections, Intraven

2001
Regional accumulation of 14C-zonisamide in rat brain during kainic acid-induced limbic seizures.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2001, Volume: 28, Issue:4

    Topics: Animals; Anticonvulsants; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Injections, Intraven

2001