zonisamide has been researched along with Neuroblastoma in 3 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of zonisamide, a new antiepileptic drug, on voltage-dependent T-type calcium current (ICa) in cultured neuroblastoma cells of human origin (NB-I)." | 3.69 | Mechanisms of T-type calcium channel blockade by zonisamide. ( Kito, M; Maehara, M; Watanabe, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawajiri, S | 1 |
| Machida, Y | 1 |
| Saiki, S | 1 |
| Sato, S | 1 |
| Hattori, N | 1 |
| Omura, T | 1 |
| Asari, M | 1 |
| Yamamoto, J | 1 |
| Kamiyama, N | 1 |
| Oka, K | 1 |
| Hoshina, C | 1 |
| Maseda, C | 1 |
| Awaya, T | 1 |
| Tasaki, Y | 1 |
| Shiono, H | 1 |
| Shimizu, K | 1 |
| Matsubara, K | 1 |
| Kito, M | 1 |
| Maehara, M | 1 |
| Watanabe, K | 1 |
3 other studies available for zonisamide and Neuroblastoma
| Article | Year |
|---|---|
Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Antioxidants; Apoptosis; Caspases; Cell Differentiatio | 2010 |
HRD1 levels increased by zonisamide prevented cell death and caspase-3 activation caused by endoplasmic reticulum stress in SH-SY5Y cells.
Topics: Anticonvulsants; Caspase 3; Caspase Inhibitors; Cell Death; Cell Line, Tumor; Endoplasmic Reticulum | 2012 |
Mechanisms of T-type calcium channel blockade by zonisamide.
Topics: Anticonvulsants; Calcium Channel Blockers; Cell Culture Techniques; Epilepsy; Humans; Isoxazoles; Ne | 1996 |