zonisamide has been researched along with Epilepsy, Tonic-Clonic in 12 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zonisamide is an antiepileptic drug mainly used in patients with refractory epilepsy." | 5.39 | [Bilateral urolithiasis with zonisamide developed for a short period of time in a 10-year-old girl with intractable epilepsy]. ( Hirobe, M; Nishinaka, K; Sato, S; Takahashi, S; Tsukamoto, T, 2013) |
| "Zonisamide is an antiepileptic drug mainly used in patients with refractory epilepsy." | 1.39 | [Bilateral urolithiasis with zonisamide developed for a short period of time in a 10-year-old girl with intractable epilepsy]. ( Hirobe, M; Nishinaka, K; Sato, S; Takahashi, S; Tsukamoto, T, 2013) |
| "Carbamazepine was progressively withdrawn and the patient was progressively switched to zonisamide." | 1.35 | Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation. ( Coubes, P; Crespel, A; Gélisse, P; Genton, P; Velizarova, R, 2009) |
| "The recommended treatment for juvenile myoclonic epilepsy (JME) is valproate (VPA)." | 1.32 | Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. ( Hardison, H; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Valencia, I, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 8 (66.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coppola, G | 1 |
| Piccorossi, A | 1 |
| Operto, FF | 1 |
| Verrotti, A | 1 |
| Sato, S | 1 |
| Nishinaka, K | 1 |
| Takahashi, S | 1 |
| Hirobe, M | 1 |
| Tsukamoto, T | 1 |
| Patel, NC | 1 |
| Davenport, RD | 1 |
| Patel, HN | 1 |
| Crespel, A | 1 |
| Velizarova, R | 1 |
| Genton, P | 1 |
| Coubes, P | 1 |
| Gélisse, P | 1 |
| Hashimoto, Y | 1 |
| Araki, H | 1 |
| Futagami, K | 1 |
| Kawasaki, H | 1 |
| Gomita, Y | 1 |
| Kothare, SV | 1 |
| Valencia, I | 1 |
| Khurana, DS | 1 |
| Hardison, H | 1 |
| Melvin, JJ | 1 |
| Legido, A | 1 |
| Masumizu, T | 1 |
| Noda, Y | 1 |
| Mori, A | 1 |
| Packer, L | 1 |
| Arita, K | 1 |
| Kurisu, K | 1 |
| Iida, K | 1 |
| Hanaya, R | 1 |
| Akimitsu, T | 1 |
| Hibino, S | 1 |
| Pant, B | 1 |
| Hamasaki, M | 1 |
| Shinagawa, S | 1 |
| Kanazawa, O | 1 |
| Mutoh, K | 1 |
| Hidaka, Y | 1 |
| Hirose, Y | 1 |
| Kimura, M | 1 |
| Miura, Y | 1 |
| Amano, S | 1 |
| Torii, R | 1 |
| Ihara, N | 1 |
| Shimizu, A | 1 |
| Yamamoto, J | 1 |
| Yamada, Y | 1 |
| Tanaka, M | 1 |
| Kawasaki, T | 1 |
2 reviews available for zonisamide and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Anticonvulsant drugs for generalized tonic-clonic epilepsy.
Topics: Acetamides; Anticonvulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Fructose; Humans | 2017 |
Refractory grand mal seizures with onset during infancy including severe myoclonic epilepsy in infancy.
Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Humans; Infant; Isoxazoles; Zonisami | 2001 |
10 other studies available for zonisamide and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
[Bilateral urolithiasis with zonisamide developed for a short period of time in a 10-year-old girl with intractable epilepsy].
Topics: Anticonvulsants; Child; Dehydration; Disease Progression; Epilepsy, Tonic-Clonic; Female; Humans; Hy | 2013 |
Treatment of seizures in a patient with Batten's disease.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Humans; Isoxazoles; Levet | 2008 |
Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Clonazepam; Diagnostic Errors; Drug Thera | 2009 |
Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Epilepsy, Tonic-Clonic; Flurothyl; Isoxazoles; Ki | 2003 |
Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug | 2004 |
Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Electron Spin Resonance Spectroscopy; Epilepsy, Tonic-Cloni | 2005 |
Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case report.
Topics: Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Epilepsy, To | 1998 |
Possible induction of systemic lupus erythematosus by zonisamide.
Topics: Antibodies, Antinuclear; Anticonvulsants; Child, Preschool; Epilepsy, Tonic-Clonic; Humans; Isoxazol | 2001 |
Clobazam shows a different antiepileptic action profile from clonazepam and zonisamide in Ihara epileptic rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Circadian Rhythm; Clobazam; Clonazep | 2002 |
The antiepileptic effect of zonisamide on patients with refractory seizures and its side effect.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Ep | 1988 |