zonisamide has been researched along with Epilepsy, Complex Partial in 4 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Epilepsy, Complex Partial: A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Antiepileptics (carbamazepine, sodium valproate, zonisamide, clobazam, and topiramate), which are used for complex partial epilepsy or secondary generalized epilepsy in clinical practice, were orally administrated to kindled rats." | 3.76 | The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. ( Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| " The most common adverse events were somnolence, headache, dizziness, and nausea during the titration phase and headache and pharyngitis during the fixed-dose assessment phase." | 2.71 | Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures. ( Bitenskyy, V; Brodie, MJ; Duncan, R; Lucas, C; Solyom, A; Vespignani, H, 2005) |
| "Zonisamide is a sulfonamide antiepilepsy drug with sodium and calcium channel-blocking actions." | 2.70 | Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures. ( Ayala, R; Faught, E; Leppik, IE; Montouris, GG, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujiwara, A | 1 |
| Watanabe, Y | 1 |
| Takechi, K | 1 |
| Ishikawa, T | 1 |
| Kaida, Y | 1 |
| Akagi, M | 1 |
| Kamei, C | 1 |
| Noguchi, T | 1 |
| Fukatsu, N | 1 |
| Kato, H | 1 |
| Oshima, T | 1 |
| Kanemoto, K | 1 |
| Brodie, MJ | 1 |
| Duncan, R | 1 |
| Vespignani, H | 1 |
| Solyom, A | 1 |
| Bitenskyy, V | 1 |
| Lucas, C | 1 |
| Faught, E | 1 |
| Ayala, R | 1 |
| Montouris, GG | 1 |
| Leppik, IE | 1 |
2 trials available for zonisamide and Epilepsy, Complex Partial
| Article | Year |
|---|---|
Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Dose-Response Relationship, Drug; Doub | 2005 |
Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cross-Over Studies; Dose-Response Relationship, Drug; Doub | 2001 |
2 other studies available for zonisamide and Epilepsy, Complex Partial
| Article | Year |
|---|---|
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electri | 2010 |
Impact of antiepileptic drugs on genesis of psychosis.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Complex Partial; Female; Follow-Up Studies; Humans; In | 2012 |