zonisamide has been researched along with Epilepsy, Absence in 11 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Epilepsy, Absence: A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, zonisamide- and carbamazepine-treated animals had IT values similar to those of controls, but only zonisamide significantly decreased absence seizure development." | 3.77 | Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model. ( Citraro, R; Constanti, A; De Fazio, S; De Sarro, G; Di Paola, ED; Perrota, I; Perrotta, I; Russo, E; Scicchitano, F, 2011) |
| "Overall, only 24% of the 759 reported seizures had an associated EEG correlate, indicating a high over-reporting rate, which occurred in 57% of patients." | 1.91 | How accurately do adult patients report their absence seizures? ( O'Sullivan, S; Pizarro, J; Walker, MC, 2023) |
| "This is a case report of an adult with childhood absence epilepsy whose daily absence seizures ceased with adjunctive ezogabine." | 1.40 | Ezogabine treatment of childhood absence epilepsy. ( Vossler, DG; Yilmaz, U, 2014) |
| " The mean dosage of ZNS was 388 mg." | 1.40 | Zonisamide for refractory juvenile absence epilepsy. ( Crespel, A; Gelisse, P; Genton, P; Serafini, A; Velizarova, R, 2014) |
| "Valproic acid is an effective anti-epileptic medication often used for long-term control of seizure disorders that has been implicated in hematological toxicities, including rare reports of myelodysplasia and acute leukemia." | 1.35 | Translocation-positive acute myeloid leukemia associated with valproic acid therapy. ( Ben-Ezra, J; Massey, GV; Riley, RS; Russell, EC; Williams, DC, 2008) |
| "The recommended treatment for juvenile myoclonic epilepsy (JME) is valproate (VPA)." | 1.32 | Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. ( Hardison, H; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Valencia, I, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Pizarro, J | 1 |
| O'Sullivan, S | 1 |
| Walker, MC | 1 |
| Liu, NN | 1 |
| Xie, H | 1 |
| Xiang-Wei, WS | 1 |
| Gao, K | 1 |
| Wang, TS | 1 |
| Jiang, YW | 1 |
| Vossler, DG | 1 |
| Yilmaz, U | 1 |
| Velizarova, R | 1 |
| Crespel, A | 1 |
| Genton, P | 1 |
| Serafini, A | 1 |
| Gelisse, P | 1 |
| Russo, E | 1 |
| Citraro, R | 1 |
| Scicchitano, F | 1 |
| De Fazio, S | 1 |
| Perrotta, I | 1 |
| Perrota, I | 1 |
| Di Paola, ED | 1 |
| Constanti, A | 1 |
| De Sarro, G | 1 |
| Kelemen, A | 1 |
| Rásonyl, G | 1 |
| Neuwirth, M | 1 |
| Barcs, G | 1 |
| Szucs, A | 1 |
| Jakus, R | 1 |
| Fabó, D | 1 |
| Juhos, V | 1 |
| Pálfy, B | 1 |
| Halász, P | 1 |
| French, JA | 1 |
| Kanner, AM | 1 |
| Bautista, J | 1 |
| Abou-Khalil, B | 1 |
| Browne, T | 1 |
| Harden, CL | 1 |
| Theodore, WH | 1 |
| Bazil, C | 1 |
| Stern, J | 1 |
| Schachter, SC | 1 |
| Bergen, D | 1 |
| Hirtz, D | 1 |
| Montouris, GD | 1 |
| Nespeca, M | 1 |
| Gidal, B | 1 |
| Marks, WJ | 1 |
| Turk, WR | 1 |
| Fischer, JH | 1 |
| Bourgeois, B | 1 |
| Wilner, A | 1 |
| Faught, RE | 1 |
| Sachdeo, RC | 1 |
| Beydoun, A | 1 |
| Glauser, TA | 1 |
| Kothare, SV | 1 |
| Valencia, I | 1 |
| Khurana, DS | 1 |
| Hardison, H | 1 |
| Melvin, JJ | 1 |
| Legido, A | 1 |
| Williams, DC | 1 |
| Massey, GV | 1 |
| Russell, EC | 1 |
| Riley, RS | 1 |
| Ben-Ezra, J | 1 |
| Kotani, H | 1 |
| Hirai, K | 1 |
| Nishiki, T | 1 |
| Yamazoe, I | 1 |
| Okano, S | 1 |
| Takeuchi, Y | 1 |
| Yoshioka, H | 1 |
| Sawada, T | 1 |
| Shimizu, A | 1 |
| Yamamoto, J | 1 |
| Yamada, Y | 1 |
| Tanaka, M | 1 |
| Kawasaki, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 3: Metabolism of Lamotrigine During Treatment With Oral Contraceptives[NCT00266149] | Phase 3 | 10 participants | Interventional | 2003-06-30 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for zonisamide and Epilepsy, Absence
| Article | Year |
|---|---|
Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Antipsychotic Agents; Carbamazepine; Child; Clinic | 2004 |
10 other studies available for zonisamide and Epilepsy, Absence
| Article | Year |
|---|---|
How accurately do adult patients report their absence seizures?
Topics: Adult; Epilepsy, Absence; Female; Humans; Inpatients; Male; Seizures; Valproic Acid; Zonisamide | 2023 |
The absence of NIPA2 enhances neural excitability through BK (big potassium) channels.
Topics: Action Potentials; Animals; Cation Transport Proteins; Epilepsy, Absence; Female; Large-Conductance | 2019 |
Ezogabine treatment of childhood absence epilepsy.
Topics: Anticonvulsants; Carbamates; Drug Interactions; Electroencephalography; Epilepsy, Absence; Female; H | 2014 |
Zonisamide for refractory juvenile absence epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy, Absence; Female; Humans; Isoxazoles; Longitudinal Studies; Male; M | 2014 |
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Depression; Dose-Response Relationship, Drug; Electr | 2011 |
Our clinical experience with zonisamide in resistant generalized epilepsy syndromes.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Confusion; Disorders of Excessive Somno | 2011 |
Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug | 2004 |
Translocation-positive acute myeloid leukemia associated with valproic acid therapy.
Topics: Acute Disease; Anticonvulsants; Cell Differentiation; Cell Division; Child, Preschool; Chromosomes, | 2008 |
[Zonisamide monotherapy against absence attacks: report of two cases].
Topics: Child; Electroencephalography; Epilepsy, Absence; Female; Humans; Isoxazoles; Zonisamide | 1994 |
The antiepileptic effect of zonisamide on patients with refractory seizures and its side effect.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Ep | 1988 |