zonisamide has been researched along with Cortical Lewy Body Disease in 13 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zonisamide is an anti-epileptic medication with multiple mechanisms of action and a favorable safety profile." | 6.72 | The Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data. ( Leverenz, JB; Tousi, B, 2021) |
| " No unexpected neurological or psychiatric adverse events occurred, and no adverse events increased in incidence in the open-label period." | 3.11 | Long-Term Efficacy and Safety of Zonisamide for Treatment of Parkinsonism in Patients With Dementia With Lewy Bodies: An Open-Label Extension of a Phase three Randomized Controlled Trial. ( Hasegawa, K; Kajiwara, R; Kosaka, K; Murata, M; Odawara, T; Tagawa, M; Takeuchi, H, 2022) |
| " Other outcomes included the changes in Mini-Mental State Examination (MMSE) and Neuropsychiatric Inventory-10 (NPI-10) scores, and the incidence of adverse events." | 3.01 | Efficacy and Safety of Zonisamide in Dementia with Lewy Bodies Patients with Parkinsonism: A Post Hoc Analysis of Two Randomized, Double-Blind, Placebo-Controlled Trials. ( Hasegawa, K; Kochi, K; Konishi, O; Maruyama, H; Odawara, T; Toya, S, 2021) |
| "Zonisamide appears to be a new treatment option for patients with PD and DLB." | 2.82 | Zonisamide's Efficacy and Safety on Parkinson's Disease and Dementia with Lewy Bodies: A Meta-Analysis and Systematic Review. ( Jiang, Z; Kong, L; Liu, H; Wang, Z; Xi, J; Yu, X, 2022) |
| "Zonisamide is an anti-epileptic medication with multiple mechanisms of action and a favorable safety profile." | 2.72 | The Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data. ( Leverenz, JB; Tousi, B, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 8 (61.54) | 2.80 |
| Authors | Studies |
|---|---|
| Kong, L | 1 |
| Xi, J | 1 |
| Jiang, Z | 1 |
| Yu, X | 1 |
| Liu, H | 1 |
| Wang, Z | 1 |
| Ikeda, M | 1 |
| Mori, E | 1 |
| Orimo, S | 1 |
| Yamada, T | 1 |
| Konishi, O | 2 |
| Murata, M | 3 |
| Odawara, T | 5 |
| Hasegawa, K | 4 |
| Kajiwara, R | 2 |
| Takeuchi, H | 2 |
| Tagawa, M | 3 |
| Kosaka, K | 3 |
| Panza, F | 1 |
| Lozupone, M | 1 |
| Watling, M | 1 |
| Imbimbo, BP | 1 |
| Kochi, K | 1 |
| Maruyama, H | 1 |
| Toya, S | 1 |
| Tousi, B | 1 |
| Leverenz, JB | 1 |
| Hinkle, JT | 1 |
| Pontone, GM | 1 |
| Hershey, LA | 2 |
| Irwin, DJ | 1 |
| Iiyama, S | 1 |
| Nakamura, M | 1 |
| Coleman-Jackson, R | 1 |
| Shiozaki, K | 1 |
| Togo, T | 1 |
| Hirayasu, Y | 1 |
| Sato, S | 1 |
| Mizukami, K | 1 |
| Asada, T | 1 |
3 reviews available for zonisamide and Cortical Lewy Body Disease
| Article | Year |
|---|---|
Zonisamide's Efficacy and Safety on Parkinson's Disease and Dementia with Lewy Bodies: A Meta-Analysis and Systematic Review.
Topics: Contusions; Humans; Lewy Body Disease; Parkinson Disease; Sleepiness; Zonisamide | 2022 |
The Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data.
Topics: Clinical Trials, Phase III as Topic; Dementia; Humans; Lewy Body Disease; Zonisamide | 2021 |
Pharmacological Management of Dementia with Lewy Bodies.
Topics: Age Factors; Aged; Anticonvulsants; Antiparkinson Agents; Cholinesterase Inhibitors; Clinical Trials | 2019 |
5 trials available for zonisamide and Cortical Lewy Body Disease
| Article | Year |
|---|---|
Efficacy of Adjunctive Therapy with Zonisamide Versus Increased Dose of Levodopa for Motor Symptoms in Patients with Dementia with Lewy Bodies: The Randomized, Controlled, Non-Inferiority DUEL Study.
Topics: Humans; Levodopa; Lewy Body Disease; Zonisamide | 2023 |
Effect of zonisamide on parkinsonism in patients with dementia with Lewy bodies: A phase 3 randomized clinical trial.
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Double-Blind Method; Dyskinesias; Female; Humans; | 2020 |
Efficacy and Safety of Zonisamide in Dementia with Lewy Bodies Patients with Parkinsonism: A Post Hoc Analysis of Two Randomized, Double-Blind, Placebo-Controlled Trials.
Topics: Aged; Anticonvulsants; Double-Blind Method; Female; Humans; Japan; Lewy Body Disease; Male; Neuropsy | 2021 |
Long-Term Efficacy and Safety of Zonisamide for Treatment of Parkinsonism in Patients With Dementia With Lewy Bodies: An Open-Label Extension of a Phase three Randomized Controlled Trial.
Topics: Double-Blind Method; Humans; Lewy Body Disease; Outpatients; Parkinsonian Disorders; Treatment Outco | 2022 |
Adjunct zonisamide to levodopa for DLB parkinsonism: A randomized double-blind phase 2 study.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Double-Blind Method; Drug Therapy, Combination; Femal | 2018 |
5 other studies available for zonisamide and Cortical Lewy Body Disease
| Article | Year |
|---|---|
Pharmacological management of dementia with Lewy bodies with a focus on zonisamide for treating parkinsonism.
Topics: Brain; Europe; Humans; Levodopa; Lewy Body Disease; Zonisamide | 2021 |
Invited Perspective on the "Long-Term Efficacy and Safety of Zonisamide for Treatment of Parkinsonism in Patients With Dementia With Lewy Bodies: An Open-label Extension of a Phase 3 Randomized Controlled Trial".
Topics: Double-Blind Method; Humans; Lewy Body Disease; Parkinsonian Disorders; Zonisamide | 2022 |
Zonisamide for DLB parkinsonism: An old drug used in a new context.
Topics: Double-Blind Method; Humans; Levodopa; Lewy Body Disease; Parkinsonian Disorders; Zonisamide | 2018 |
Administration of zonisamide in three cases of dementia with Lewy bodies.
Topics: Aged; Antiparkinson Agents; Caregivers; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 2010 |
Successful treatment of extrapyramidal and psychotic symptoms with zonisamide in a patient with dementia with Lewy bodies.
Topics: Aged; Basal Ganglia Diseases; Female; Humans; Isoxazoles; Lewy Body Disease; Psychotic Disorders; Tr | 2010 |