zonisamide has been researched along with Complications, Pregnancy in 9 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Animal data suggest teratogenic effects with zonisamide use and risk of pregnancy losses." | 8.02 | Zonisamide safety in pregnancy: Data from the UK and Ireland epilepsy and pregnancy register. ( Bromley, R; Campbell, E; Craig, JJ; Delanty, N; Heath, C; Hunt, SJ; Irwin, B; Kinney, MO; Liggan, B; MacKillop, L; McCluskey, G; Morrison, PJ; Morrow, J; Murphy, S; Parsons, L; Russell, A; Smithson, WH, 2021) |
| "To investigate the change in zonisamide (ZNS) serum concentration and its consequences in pregnant women with epilepsy." | 7.88 | Zonisamide serum concentrations during pregnancy. ( Aurlien, D; Becser Andersen, N; Brodtkorb, E; Christensen, J; Haggag, K; Helde, G; Lillestølen, KM; Nakken, KO; Reimers, A; Surlien Navjord, E, 2018) |
| "A 30-year-old woman with primary generalized tonic-clonic seizures and myoclonic jerks was taking zonisamide 200 mg daily as her sole antiepileptic agent when she conceived." | 7.74 | Zonisamide concentrations during pregnancy. ( Bell, WL; Oles, KS, 2008) |
| "Pregnancy is a state where drug pharmacokinetic changes are more pronounced and more rapid than any other period of life." | 5.48 | Effect of zonisamide on refractory epilepsy during pregnancy in lamotrigine resistant kindled rats. ( Keramati, K; Mahdavi, A; Moezifar, M; Narenji Sani, R; Saberi, N, 2018) |
| "Anencephaly was detected in one case at 16 weeks of gestation (case 1, artificial abortion), and atrial septal defect was detected in another case at 37 weeks of gestation (case 2, delivery by cesarean section)." | 5.29 | Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy. ( Amano, Y; Egawa, I; Kaneko, S; Kondo, T, 1996) |
| "05) of an increased hazard of fetal malformation associated with exposure to valproate, carbamazepine, topiramate, zonisamide, and with conception after assisted fertilization, but a reduced hazard in the offspring of women who continued to smoke during pregnancy." | 4.31 | Specific fetal malformations following intrauterine exposure to antiseizure medication. ( Eadie, M; Graham, J; Hitchcock, A; Lander, C; O'Brien, T; Perucca, P; Vajda, F, 2023) |
| "Animal data suggest teratogenic effects with zonisamide use and risk of pregnancy losses." | 4.02 | Zonisamide safety in pregnancy: Data from the UK and Ireland epilepsy and pregnancy register. ( Bromley, R; Campbell, E; Craig, JJ; Delanty, N; Heath, C; Hunt, SJ; Irwin, B; Kinney, MO; Liggan, B; MacKillop, L; McCluskey, G; Morrison, PJ; Morrow, J; Murphy, S; Parsons, L; Russell, A; Smithson, WH, 2021) |
| "To investigate the change in zonisamide (ZNS) serum concentration and its consequences in pregnant women with epilepsy." | 3.88 | Zonisamide serum concentrations during pregnancy. ( Aurlien, D; Becser Andersen, N; Brodtkorb, E; Christensen, J; Haggag, K; Helde, G; Lillestølen, KM; Nakken, KO; Reimers, A; Surlien Navjord, E, 2018) |
| "A 30-year-old woman with primary generalized tonic-clonic seizures and myoclonic jerks was taking zonisamide 200 mg daily as her sole antiepileptic agent when she conceived." | 3.74 | Zonisamide concentrations during pregnancy. ( Bell, WL; Oles, KS, 2008) |
| "Zonisamide is widely used for intractable epilepsy and the effects of this drug on fetuses and neonates through the mother taking it for epilepsy need to be clarified." | 3.71 | Pharmacokinetics of zonisamide in perinatal period. ( Ishii, M; Isobe, K; Itoh, S; Kawada, K; Kusaka, T, 2002) |
| "Pregnancy is a state where drug pharmacokinetic changes are more pronounced and more rapid than any other period of life." | 1.48 | Effect of zonisamide on refractory epilepsy during pregnancy in lamotrigine resistant kindled rats. ( Keramati, K; Mahdavi, A; Moezifar, M; Narenji Sani, R; Saberi, N, 2018) |
| "The etiology of Moebius syndrome remains unknown." | 1.34 | A case of Moebius syndrome presenting with congenital bilateral vocal cord paralysis. ( Arinami, T; Hasegawa, M; Kamoda, T; Kanemoto, K; Kanemoto, N, 2007) |
| "Anencephaly was detected in one case at 16 weeks of gestation (case 1, artificial abortion), and atrial septal defect was detected in another case at 37 weeks of gestation (case 2, delivery by cesarean section)." | 1.29 | Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy. ( Amano, Y; Egawa, I; Kaneko, S; Kondo, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Vajda, F | 1 |
| O'Brien, T | 1 |
| Graham, J | 1 |
| Hitchcock, A | 1 |
| Perucca, P | 1 |
| Lander, C | 1 |
| Eadie, M | 1 |
| McCluskey, G | 1 |
| Kinney, MO | 1 |
| Russell, A | 1 |
| Smithson, WH | 1 |
| Parsons, L | 1 |
| Morrison, PJ | 1 |
| Bromley, R | 1 |
| MacKillop, L | 1 |
| Heath, C | 1 |
| Liggan, B | 1 |
| Murphy, S | 1 |
| Delanty, N | 1 |
| Irwin, B | 1 |
| Campbell, E | 1 |
| Morrow, J | 1 |
| Hunt, SJ | 1 |
| Craig, JJ | 1 |
| Narenji Sani, R | 1 |
| Keramati, K | 1 |
| Saberi, N | 1 |
| Moezifar, M | 1 |
| Mahdavi, A | 1 |
| Reimers, A | 1 |
| Helde, G | 1 |
| Becser Andersen, N | 1 |
| Aurlien, D | 1 |
| Surlien Navjord, E | 1 |
| Haggag, K | 1 |
| Christensen, J | 1 |
| Lillestølen, KM | 1 |
| Nakken, KO | 1 |
| Brodtkorb, E | 1 |
| Oles, KS | 1 |
| Bell, WL | 1 |
| Terada, K | 1 |
| Inoue, Y | 1 |
| Kanemoto, N | 1 |
| Kanemoto, K | 1 |
| Kamoda, T | 1 |
| Hasegawa, M | 1 |
| Arinami, T | 1 |
| Kondo, T | 1 |
| Kaneko, S | 1 |
| Amano, Y | 1 |
| Egawa, I | 1 |
| Kawada, K | 1 |
| Itoh, S | 1 |
| Kusaka, T | 1 |
| Isobe, K | 1 |
| Ishii, M | 1 |
9 other studies available for zonisamide and Complications, Pregnancy
| Article | Year |
|---|---|
Specific fetal malformations following intrauterine exposure to antiseizure medication.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Carbamazepine; Female; Humans; Male; Pregna | 2023 |
Zonisamide safety in pregnancy: Data from the UK and Ireland epilepsy and pregnancy register.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Ireland; | 2021 |
Effect of zonisamide on refractory epilepsy during pregnancy in lamotrigine resistant kindled rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Drug Resistance; Drug Resistant Epilepsy; Female; | 2018 |
Zonisamide serum concentrations during pregnancy.
Topics: Adult; Denmark; Drug Monitoring; Epilepsy; Female; Gestational Age; Humans; Norway; Pregnancy; Pregn | 2018 |
Zonisamide concentrations during pregnancy.
Topics: Adult; Anticonvulsants; Female; Humans; Isoxazoles; Myoclonic Epilepsy, Juvenile; Pregnancy; Pregnan | 2008 |
[Clinical application of newer anti-epileptic drugs].
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma- | 2012 |
A case of Moebius syndrome presenting with congenital bilateral vocal cord paralysis.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Isoxazoles; Mobius Syndrome; Pregnancy; | 2007 |
Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anencephaly; Anticonvulsants; Epilepsy; Female; Humans; Infant, | 1996 |
Pharmacokinetics of zonisamide in perinatal period.
Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; Female; Fetal Blood; Humans; | 2002 |