zonisamide has been researched along with Brain Ischemia in 3 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies." | 5.62 | Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis. ( Chen, R; Chen, Y; He, J; He, W; Xie, Y; Yang, Y; Zhang, X, 2021) |
| "Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies." | 1.62 | Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis. ( Chen, R; Chen, Y; He, J; He, W; Xie, Y; Yang, Y; Zhang, X, 2021) |
| "When zonisamide (75 mg/kg) was administered i." | 1.29 | Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect. ( Hattori, H; Hayakawa, T; Higuchi, Y; Nigami, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| He, J | 1 |
| Zhang, X | 1 |
| He, W | 1 |
| Xie, Y | 1 |
| Chen, Y | 1 |
| Yang, Y | 1 |
| Chen, R | 1 |
| Costa, C | 1 |
| Tozzi, A | 1 |
| Siliquini, S | 1 |
| Galletti, F | 1 |
| Cardaioli, G | 1 |
| Tantucci, M | 1 |
| Pisani, F | 1 |
| Calabresi, P | 1 |
| Hayakawa, T | 1 |
| Higuchi, Y | 1 |
| Nigami, H | 1 |
| Hattori, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial[NCT05131295] | Phase 3 | 49 participants (Actual) | Interventional | 2007-09-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for zonisamide and Brain Ischemia
| Article | Year |
|---|---|
Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis.
Topics: Animals; Apoptosis; Brain Ischemia; Infarction, Middle Cerebral Artery; Mice; Neuroprotective Agents | 2021 |
A critical role of NO/cGMP/PKG dependent pathway in hippocampal post-ischemic LTP: modulation by zonisamide.
Topics: Animals; Anticonvulsants; Brain Ischemia; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease | 2011 |
Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect.
Topics: Animals; Anticonvulsants; Body Temperature; Brain; Brain Ischemia; Electroencephalography; Hippocamp | 1994 |