Page last updated: 2024-11-05

zonisamide and Alcoholism

zonisamide has been researched along with Alcoholism in 6 studies

Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.

Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)

Research Excerpts

ExcerptRelevanceReference
"Zonisamide is an anticonvulsant medication with GABAergic, glutamatergic, and monoaminergic effects."2.75Placebo-controlled trial of zonisamide for the treatment of alcohol dependence. ( Arias, AJ; Covault, J; Feinn, R; Kranzler, HR; Oncken, C, 2010)
"Diazepam was administered using a similar regimen (from 130-50 mg/day tapering to 5-15 mg/day)."2.75Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome. ( Alamo, C; Ferre, F; Jiménez-Arriero, MÁ; López-Muñoz, F; Martínez-Gras, I; Pascual, JM; Ponce, G; Rubio, G, 2010)
"The comorbidity between alcohol use disorder and post-traumatic stress disorder represents a serious health care burden with few effective treatment options."1.56Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress. ( Becker, HC; Carper, BA; Lopez, MF; Nolen, TL; Reasons, SE; Williams, RL, 2020)
"Zonisamide is a new anti-epileptic drug whose mechanism of action is associated with neurotransmission systems also involved in the pathogenesis of addiction."1.46The Impact of Zonisamide on the Development and Course of Alcohol Dependence in Rabbits. A pharmaco-EEG study. ( Kordala, A; Krupa-Burtnik, A; Pietrzak, B; Zwierzynska, E, 2017)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Pietrzak, B2
Krupa-Burtnik, A2
Zwierzyńska, E2
Lopez, MF1
Reasons, SE1
Carper, BA1
Nolen, TL1
Williams, RL1
Becker, HC1
Kordala, A1
Coelho, R1
Rodrigues, S1
Gaspar, R1
Silva, R1
Lopes, J1
Macedo, G1
Arias, AJ1
Feinn, R1
Oncken, C1
Covault, J1
Kranzler, HR1
Rubio, G1
López-Muñoz, F1
Ponce, G1
Pascual, JM1
Martínez-Gras, I1
Ferre, F1
Jiménez-Arriero, MÁ1
Alamo, C1

Trials

2 trials available for zonisamide and Alcoholism

ArticleYear
Placebo-controlled trial of zonisamide for the treatment of alcohol dependence.
    Journal of clinical psychopharmacology, 2010, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Aged; Alcoholism; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle A

2010
Placebo-controlled trial of zonisamide for the treatment of alcohol dependence.
    Journal of clinical psychopharmacology, 2010, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Aged; Alcoholism; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle A

2010
Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome.
    Pharmacopsychiatry, 2010, Volume: 43, Issue:7

    Topics: Adult; Alcoholism; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Hum

2010
Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome.
    Pharmacopsychiatry, 2010, Volume: 43, Issue:7

    Topics: Adult; Alcoholism; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Hum

2010

Other Studies

4 other studies available for zonisamide and Alcoholism

ArticleYear
The Effect of Zonisamide and Ethanol on Various Types of Memory in Rats.
    International journal of environmental research and public health, 2023, 01-18, Volume: 20, Issue:3

    Topics: Alcoholism; Animals; Anticonvulsants; Ethanol; Hippocampus; Rats; Rats, Wistar; Zonisamide

2023
The Effect of Zonisamide and Ethanol on Various Types of Memory in Rats.
    International journal of environmental research and public health, 2023, 01-18, Volume: 20, Issue:3

    Topics: Alcoholism; Animals; Anticonvulsants; Ethanol; Hippocampus; Rats; Rats, Wistar; Zonisamide

2023
Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress.
    Alcohol (Fayetteville, N.Y.), 2020, Volume: 89

    Topics: Alcohol Drinking; Alcoholism; Animals; Doxazosin; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; S

2020
Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress.
    Alcohol (Fayetteville, N.Y.), 2020, Volume: 89

    Topics: Alcohol Drinking; Alcoholism; Animals; Doxazosin; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; S

2020
The Impact of Zonisamide on the Development and Course of Alcohol Dependence in Rabbits. A pharmaco-EEG study.
    Alcohol and alcoholism (Oxford, Oxfordshire), 2017, May-01, Volume: 52, Issue:3

    Topics: Administration, Oral; Alcoholism; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electr

2017
The Impact of Zonisamide on the Development and Course of Alcohol Dependence in Rabbits. A pharmaco-EEG study.
    Alcohol and alcoholism (Oxford, Oxfordshire), 2017, May-01, Volume: 52, Issue:3

    Topics: Administration, Oral; Alcoholism; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electr

2017
Zonisamide-induced Acute-on-Chronic Liver Failure: First Report.
    Journal of clinical gastroenterology, 2016, Volume: 50, Issue:3

    Topics: Acute-On-Chronic Liver Failure; Adult; Alcoholism; Anticonvulsants; Epilepsy; Female; Humans; Isoxaz

2016
Zonisamide-induced Acute-on-Chronic Liver Failure: First Report.
    Journal of clinical gastroenterology, 2016, Volume: 50, Issue:3

    Topics: Acute-On-Chronic Liver Failure; Adult; Alcoholism; Anticonvulsants; Epilepsy; Female; Humans; Isoxaz

2016