zonisamide has been researched along with Alcoholism in 6 studies
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.
zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zonisamide is an anticonvulsant medication with GABAergic, glutamatergic, and monoaminergic effects." | 2.75 | Placebo-controlled trial of zonisamide for the treatment of alcohol dependence. ( Arias, AJ; Covault, J; Feinn, R; Kranzler, HR; Oncken, C, 2010) |
| "Diazepam was administered using a similar regimen (from 130-50 mg/day tapering to 5-15 mg/day)." | 2.75 | Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome. ( Alamo, C; Ferre, F; Jiménez-Arriero, MÁ; López-Muñoz, F; Martínez-Gras, I; Pascual, JM; Ponce, G; Rubio, G, 2010) |
| "The comorbidity between alcohol use disorder and post-traumatic stress disorder represents a serious health care burden with few effective treatment options." | 1.56 | Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress. ( Becker, HC; Carper, BA; Lopez, MF; Nolen, TL; Reasons, SE; Williams, RL, 2020) |
| "Zonisamide is a new anti-epileptic drug whose mechanism of action is associated with neurotransmission systems also involved in the pathogenesis of addiction." | 1.46 | The Impact of Zonisamide on the Development and Course of Alcohol Dependence in Rabbits. A pharmaco-EEG study. ( Kordala, A; Krupa-Burtnik, A; Pietrzak, B; Zwierzynska, E, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pietrzak, B | 2 |
| Krupa-Burtnik, A | 2 |
| Zwierzyńska, E | 2 |
| Lopez, MF | 1 |
| Reasons, SE | 1 |
| Carper, BA | 1 |
| Nolen, TL | 1 |
| Williams, RL | 1 |
| Becker, HC | 1 |
| Kordala, A | 1 |
| Coelho, R | 1 |
| Rodrigues, S | 1 |
| Gaspar, R | 1 |
| Silva, R | 1 |
| Lopes, J | 1 |
| Macedo, G | 1 |
| Arias, AJ | 1 |
| Feinn, R | 1 |
| Oncken, C | 1 |
| Covault, J | 1 |
| Kranzler, HR | 1 |
| Rubio, G | 1 |
| López-Muñoz, F | 1 |
| Ponce, G | 1 |
| Pascual, JM | 1 |
| Martínez-Gras, I | 1 |
| Ferre, F | 1 |
| Jiménez-Arriero, MÁ | 1 |
| Alamo, C | 1 |
2 trials available for zonisamide and Alcoholism
| Article | Year |
|---|---|
Placebo-controlled trial of zonisamide for the treatment of alcohol dependence.
Topics: Adolescent; Adult; Aged; Alcoholism; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle A | 2010 |
Placebo-controlled trial of zonisamide for the treatment of alcohol dependence.
Topics: Adolescent; Adult; Aged; Alcoholism; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle A | 2010 |
Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome.
Topics: Adult; Alcoholism; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Hum | 2010 |
Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome.
Topics: Adult; Alcoholism; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Hum | 2010 |
4 other studies available for zonisamide and Alcoholism
| Article | Year |
|---|---|
The Effect of Zonisamide and Ethanol on Various Types of Memory in Rats.
Topics: Alcoholism; Animals; Anticonvulsants; Ethanol; Hippocampus; Rats; Rats, Wistar; Zonisamide | 2023 |
The Effect of Zonisamide and Ethanol on Various Types of Memory in Rats.
Topics: Alcoholism; Animals; Anticonvulsants; Ethanol; Hippocampus; Rats; Rats, Wistar; Zonisamide | 2023 |
Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress.
Topics: Alcohol Drinking; Alcoholism; Animals; Doxazosin; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; S | 2020 |
Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress.
Topics: Alcohol Drinking; Alcoholism; Animals; Doxazosin; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; S | 2020 |
The Impact of Zonisamide on the Development and Course of Alcohol Dependence in Rabbits. A pharmaco-EEG study.
Topics: Administration, Oral; Alcoholism; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electr | 2017 |
The Impact of Zonisamide on the Development and Course of Alcohol Dependence in Rabbits. A pharmaco-EEG study.
Topics: Administration, Oral; Alcoholism; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electr | 2017 |
Zonisamide-induced Acute-on-Chronic Liver Failure: First Report.
Topics: Acute-On-Chronic Liver Failure; Adult; Alcoholism; Anticonvulsants; Epilepsy; Female; Humans; Isoxaz | 2016 |
Zonisamide-induced Acute-on-Chronic Liver Failure: First Report.
Topics: Acute-On-Chronic Liver Failure; Adult; Alcoholism; Anticonvulsants; Epilepsy; Female; Humans; Isoxaz | 2016 |