zoniporide has been researched along with Brain-Edema* in 1 studies
1 other study(ies) available for zoniporide and Brain-Edema
| Article | Year |
|---|---|
NEUROPROTECTIVE PROPERTIES OF A NEW INHIBITOR OF NA+/H+ EXCHANGER (COMPOUND RU-1355) ON THE MODEL OF FOCAL ISCHEMIA IN RATS.
Primary neuroprotective properties of new inhibitor of Na⁺/⁺ exchanger (compound RU-1355) were established on the model of 60-min focal ischemia of the left middle cerebral artery followed by 24-h reperfusion in rats. Compound RU-1355 significantly (by 34%) decreased neurological symptoms, reduced (1.67 times) the growth of neuron-specific enolase level in serum, decreased (2.3 times) the size of the necrotic zone, and reduced by 59% (p <0.05) the degree of cerebral edema According to the results of morphometric, immunoassay, and neurological assessments of brain damage, compound RU-1355 is superior on ave- rage by 43.5% (p < 0.05) in comparison to selective NHE1 inhibitor zoniporide. Topics: Animals; Animals, Outbred Strains; Benzimidazoles; Brain; Brain Edema; Brain Ischemia; Cerebral Arteries; Cerebrovascular Disorders; Female; Gene Expression; Guanidines; Neuroprotective Agents; Phosphopyruvate Hydratase; Psychomotor Performance; Pyrazoles; Rats; Reperfusion Injury; Sodium-Hydrogen Exchanger 1 | 2016 |