zomepirac and Pain, Postoperative studies

Research Excerpts

Excerpt	Relevance	Reference
"Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID), available in several different countries, but not widely used."	6.47	Single dose oral fenoprofen for acute postoperative pain in adults. ( Derry, S; Moore, RA; Traa, MX, 2011)
"Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID)."	6.47	Single dose oral mefenamic acid for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moll, R; Moore, RA, 2011)
" Flurbiprofen in 50 mg and 100 mg dosages demonstrated effective analgesic activity with the 100 mg dosage being at least as effective as the acetaminophen/codeine combination."	2.67	The analgesic efficacy of flurbiprofen compared to acetaminophen with codeine. ( Cooper, SA; Kupperman, A, 1991)
" In the multiple dosing phase, zomepirac was statistically better than dihydrocodeine."	2.66	Zomepirac, dihydrocodeine and placebo compared in postoperative pain after day-case surgery. The relationship between the effects of single and multiple doses. ( Bullingham, RE; Carroll, D; Collin, J; Evans, PJ; Lloyd, JW; McQuay, HJ; Moore, RA; O'Sullivan, G, 1985)
"Zomepirac sodium was extremely popular among clinicians and was considered the most effective of the peripherally acting analgesics."	2.65	Comparative efficacy of fenoprofen calcium and zomepirac sodium in postsurgical dental pain. ( Cohn, P; Cooper, SA; Dyer, C; Gelb, S; Goldman, E, 1984)
"Ibuprofen, 400 mg, is an effective oral analgesic and is more effective than 100 mg zomepirac and 600 mg aspirin in most parameters of pain."	2.65	Ibuprofen, zomepirac, aspirin, and placebo in the relief of postepisiotomy pain. ( De Castro, A; De Sarrazin, C; Laska, EM; Olson, NZ; Sunshine, A; Zighelboim, I, 1983)
"Zomepirac was a surprisingly effective oral analgesic in these patients, 100 mg orally being roughly equivalent to 16 mg intramuscular morphine."	2.65	Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain. ( Heidrich, G; Houde, RW; Kaiko, RF; Rogers, A; Wallenstein, SL, 1980)
"Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID), available in several different countries, but not widely used."	2.47	Single dose oral fenoprofen for acute postoperative pain in adults. ( Derry, S; Moore, RA; Traa, MX, 2011)
"Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID)."	2.47	Single dose oral mefenamic acid for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moll, R; Moore, RA, 2011)
"Ibuprofen 400 mg was consistently more effective than aspirin 650 mg, acetaminophen 600 mg, and both aspirin and acetaminophen when combined with codeine 60 mg."	1.27	Five studies on ibuprofen for postsurgical dental pain. ( Cooper, SA, 1984)
"Zomepirac appears to be an unexpectedly effective oral, non-opioid analgesic."	1.26	Clinical analgesic assay of oral zomepirac and intramuscular morphine. ( Heidrich, G; Houde, RW; Kaiko, RF; Rogers, A; Wallenstein, SL, 1979)

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (92.11)	18.7374
1990's	1 (2.63)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (5.26)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Traa, MX	1
Derry, S	2
Moore, RA	4
Moll, R	1
McQuay, HJ	3
Dunn, GL	2
Morison, DH	2
Fargas-Babjak, AM	2
Goldsmith, CH	1
Vogel, RI	1
Gross, JI	1
Crossley, HL	1
Bergman, SA	1
Wynn, RL	1
Cooper, SA	5
Maeda, K	1
Akamine, A	1
Kaida, H	1
Honda, N	1
Kishi, T	1
Onimura, K	1
Nagamine, N	1
Yamamoto, J	1
Aono, M	1
Haraga, Y	1
Mirisola, F	1
Lupo, G	1
Gelb, S	1
Goldman, E	1
Cohn, P	1
Dyer, C	1
Kinoshita, S	1
Ishikawa, I	1
Noguchi, T	1
Uraguchi, R	1
Hagiwara, S	1
Miyagawa, M	1
Kowashi, Y	1
Yamazaki, M	1
Forrest, WH	2
Honig, WJ	1
Valdez, EV	1
Sunshine, A	2
Olson, NZ	1
Laska, EM	2
Zighelboim, I	1
De Castro, A	1
De Sarrazin, C	1
Duplat, JP	1
Di Giacobbe, D	1
Onishi, M	1
Naganawa, Y	1
Aoki, K	1
Ito, H	1
Oda, H	1
Abe, M	1
Mizutani, H	1
Igarashi, K	1
Takahashi, N	1
Takagi, R	1
Baird, WM	1
Turek, D	1
Wallenstein, SL	2
Rogers, A	2
Kaiko, RF	2
Heidrich, G	2
Houde, RW	2
Mehlisch, DR	2
Joy, ED	2
Moore, TE	1
Porter, K	1
Stumpf, AJ	1
Wolfe, SH	1
Messer, RH	1
Vaughn, T	1
Harbert, G	1
deAndrade, JR	1
Honig, S	2
Ciccone, WJ	1
Leffall, L	1
Elbaz, JS	1
Bernard, A	1
Murray, KA	1
Evans, PJ	2
Rolfe, M	1
O'Sullivan, G	2
Bullingham, RE	2
Kupperman, A	1
Giglio, JA	1
Campbell, RL	1
Scott, R	1
Ellis, E	1
Upton, LG	1
Marrero, I	1
Olson, N	1
McCormick, N	1
Kurita, K	1
Sugiura, M	1
Shimogo, K	1
Hattori, T	1
Kawai, K	1
Cater, M	1
O'Brien, PM	1
Pickvance, NJ	1
Carroll, D	1
Collin, J	1
Lloyd, JW	1

Article	Year
Single dose oral fenoprofen for acute postoperative pain in adults. The Cochrane database of systematic reviews, 2011, Feb-16, Issue:2 Topics: Acute Disease; Administration, Oral; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroi	2011
Single dose oral mefenamic acid for acute postoperative pain in adults. The Cochrane database of systematic reviews, 2011, Mar-16, Issue:3 Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans	2011
Nonsteroidal anti-inflammatory agents in relieving dental pain: a review. Journal of the American Dental Association (1939), 1983, Volume: 106, Issue:1 Topics: Analgesics; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Drug Interactions; Humans; Ibup	1983
New peripherally-acting oral analgesic agents. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials	1983

Article	Year
A comparison of zomepirac and codeine as analgesic premedicants in short-stay surgery. Anesthesiology, 1983, Volume: 58, Issue:3 Topics: Adolescent; Adult; Analgesics; Anesthesia, Dental; Clinical Trials as Topic; Codeine; Double-Blind M	1983
New peripherally-acting oral analgesic agents. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials	1983
[A preliminary study on the effective dose and safety of zomepirac sodium. Pain following minor surgery and tooth extraction in the field of dentistry]. Nihon Shishubyo Gakkai kaishi, 1983, Volume: 25, Issue:2 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Mefenamic Acid; Midd	1983
Comparative efficacy of fenoprofen calcium and zomepirac sodium in postsurgical dental pain. Oral surgery, oral medicine, and oral pathology, 1984, Volume: 57, Issue:5 Topics: Adult; Analgesics; Anti-Inflammatory Agents; Evaluation Studies as Topic; Female; Fenoprofen; Humans	1984
Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain. JAMA, 1980, Nov-21, Volume: 244, Issue:20 Topics: Acute Disease; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Female; Humans; Injections, I	1980
Zomepirac as an analgesic premedication: a comparison of three dosage regimens. Canadian Anaesthetists' Society journal, 1983, Volume: 30, Issue:4 Topics: Adult; Analgesics; Anesthesia, General; Double-Blind Method; Drug Administration Schedule; Female; H	1983
Ibuprofen, zomepirac, aspirin, and placebo in the relief of postepisiotomy pain. Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:2 Topics: Adolescent; Adult; Aspirin; Episiotomy; Female; Humans; Ibuprofen; Pain, Postoperative; Placebos; Py	1983
Efficacy of zomepirac in oral surgical pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Combina	1980
Comparison of zomepirac, APC with codeine, codeine and placebo in the treatment of moderate and severe postoperative pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female;	1980
Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Administration, Oral; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Injections, Intra	1980
Oral zomepirac and intramuscular morphine in postoperative pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Administration, Oral; Analgesics; Clinical Trials as Topic; Double-Blind Method; Humans; Injections,	1980
Clinical comparison of zomepirac with APC/codeine combination in the treatment of pain following oral surgery. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female;	1980
Clinical evaluation of zomepirac and APC with codeine in the treatment of postpartum episiotomy pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Episioto	1980
Clinical comparison of zomepirac with pentazocine in the treatment of postoperative pain. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Analgesics; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Human	1980
A controlled repeat-dose comparison of zomepirac and clometacin in pain after plastic surgery. Journal of clinical pharmacology, 1980, Volume: 20, Issue:4 Topics: Adolescent; Adult; Aged; Analgesics; Clinical Trials as Topic; Double-Blind Method; Female; Humans;	1980
Zomepirac sodium vs APC with codeine for oral surgery pain. Journal of oral surgery (American Dental Association : 1965), 1981, Volume: 39, Issue:6 Topics: Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Humans	1981
Postsurgical pain: zomepirac sodium, propoxyphene/-acetaminophen combination, and placebo. Journal of clinical pharmacology, 1981, Volume: 21, Issue:10 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Clinical Trials as Topic; Dextropropoxyphene; Do	1981
Zomepirac, placebo and paracetamol/dextropropoxyphene combination compared in orthopaedic postoperative pain. British journal of anaesthesia, 1982, Volume: 54, Issue:9 Topics: Acetaminophen; Adolescent; Adult; Analgesics; Bone and Bones; Clinical Trials as Topic; Dextropropox	1982
The analgesic efficacy of flurbiprofen compared to acetaminophen with codeine. The Journal of clinical dentistry, 1991, Volume: 2, Issue:3 Topics: Acetaminophen; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Dist	1991
Comparison of etodolac, zomepirac, and placebo for relief of pain after oral surgery. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1986, Volume: 44, Issue:10 Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Doub	1986
Double-blind evaluation of etodolac (200 mg, 400 mg) compared with zomepirac (100 mg) and placebo on third molar extraction pain. Oral surgery, oral medicine, and oral pathology, 1986, Volume: 62, Issue:6 Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Doub	1986
Comparative study of flurbiprofen, zomepirac sodium, acetaminophen plus codeine, and acetaminophen for the relief of postsurgical dental pain. The American journal of medicine, 1986, Mar-24, Volume: 80, Issue:3A Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Evaluation; Drug	1986
[McN-2783 for pain following the extraction of impacted wisdom tooth--clinical evaluation]. Shikai tenbo = Dental outlook, 1985, Volume: 65, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Clinical Trials as Topic; Double-Blind Met	1985
A double-blind comparison of the new ibuprofen-codeine phosphate combination, zomepirac, and placebo in the relief of postepisiotomy pain. Clinical therapeutics, 1985, Volume: 7, Issue:4 Topics: Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Episiotomy; Female	1985
Zomepirac, dihydrocodeine and placebo compared in postoperative pain after day-case surgery. The relationship between the effects of single and multiple doses. British journal of anaesthesia, 1985, Volume: 57, Issue:4 Topics: Administration, Oral; Adult; Ambulatory Surgical Procedures; Analgesics; Codeine; Double-Blind Metho	1985

Article	Year
The effects of nonsteroidal anti-inflammatory analgesics on pain after periodontal surgery. Journal of the American Dental Association (1939), 1984, Volume: 109, Issue:5 Topics: Adolescent; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind M	1984
Five studies on ibuprofen for postsurgical dental pain. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Codeine; Drug Combinations; Female; Humans; I	1984
[Pain reduction in patients undergoing periodontal surgery treated with zomepirac sodium]. Dental Cadmos, 1983, Volume: 51, Issue:3 Topics: Adult; Analgesics; Aspirin; Female; Humans; Male; Pain, Postoperative; Periodontal Diseases; Placebo	1983
[Evaluation of the analgesic and anti-inflammatory drug "Zomepirac Na" in dental surgical pain]. Nihon Shishubyo Gakkai kaishi, 1984, Volume: 26, Issue:3 Topics: Analgesics; Anti-Inflammatory Agents; Dental Care; Double-Blind Method; Drug Evaluation; Humans; Pai	1984
[Pain therapy following meniscectomy. Comparison of zomepirac and tilidine]. MMW, Munchener medizinische Wochenschrift, 1982, Jul-16, Volume: 124, Issue:28 Topics: Adult; Analgesics; Cyclohexanecarboxylic Acids; Female; Humans; Male; Menisci, Tibial; Pain, Postope	1982
[Treatment of postoperative pain. Zomepirac, mefenamic acid and placebo]. MMW, Munchener medizinische Wochenschrift, 1982, Oct-08, Volume: 124, Issue:40 Topics: Adult; Analgesics; Double-Blind Method; Humans; Mefenamic Acid; Pain, Postoperative; Pyrroles; Rando	1982
[Drug knowledge: zomepirac (sodium) (Zomax)]. L' Infirmiere canadienne, 1982, Volume: 24, Issue:11 Topics: Adult; Humans; Pain, Postoperative; Pyrroles; Tolmetin	1982
[Analgesic effects of McN-2783 to post-extraction pain--preliminary test for the determination of proper dosage]. Shikai tenbo = Dental outlook, 1982, Volume: 59, Issue:1 Topics: Adolescent; Adult; Analgesics; Drug Evaluation; Female; Humans; Male; Middle Aged; Pain, Postoperati	1982
[Analgesic effect of McN-2783 (Zomepirac sodium) for postextraction pain]. Shikai tenbo = Dental outlook, 1982, Volume: 60, Issue:4 Topics: Analgesics; Pain, Postoperative; Pyrroles; Tolmetin; Tooth Extraction	1982
Clinical analgesic assay of oral zomepirac and intramuscular morphine. NIDA research monograph, 1979, Volume: 27 Topics: Administration, Oral; Affect; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Humans; Morp	1979

zomepirac and Pain, Postoperative

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