zolpidem has been researched along with Suicidal Ideation in 6 studies
Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
Suicidal Ideation: A risk factor for suicide attempts and completions, it is the most common of all suicidal behavior, but only a minority of ideators engage in overt self-harm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The REST-IT study found the addition of zolpidem-controlled release (CR) provided a significant reduction in observer-rated measurement of suicidal ideation (the Columbia Suicide Severity Rating Scale) in 103 depressed outpatients with insomnia and suicidal ideation, but without significant change in a self-report measure of suicidal ideation (the Scale for Suicide Ideation)." | 8.31 | The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned. ( Benca, RM; Dzurny, TN; Krystal, AD; Looney, SW; McCall, WV; McCloud, LL; Mercado, K; Rosenquist, PB, 2023) |
| "REST-IT, a, 8-week double-blind RCT, compared zolpidem extended-release (ER) versus placebo at bedtime in 103 adults with major depressive disorder with insomnia and suicidal ideation, and who received open label selective serotonin reuptake inhibitors." | 5.41 | Blinding and bias in a hypnotic clinical trial. ( Benca, RM; Krystal, AD; McCall, WV; Rumble, ME, 2021) |
| "We examined the association of insomnia, eveningness, seasonality, and rhythmicity with suicidal ideation in 103 participants with depression, insomnia, and suicidality within a larger 8-week double-blinded randomized control trial primarily examining whether cautious use of zolpidem extended-release or placebo reduced suicidal ideation." | 5.34 | An exploratory analysis of the association of circadian rhythm dysregulation and insomnia with suicidal ideation over the course of treatment in individuals with depression, insomnia, and suicidal ideation. ( Benca, RM; Dickson, DA; Krystal, AD; McCall, WV; Rosenquist, PB; Rumble, ME, 2020) |
| "The authors sought to determine whether targeted treatment of insomnia with controlled-release zolpidem (zolpidem-CR) in suicidal adults with insomnia would provide a reduction in suicidal ideation superior to placebo." | 5.30 | Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial. ( Benca, RM; Case, D; Krystal, AD; McCall, WV; McCloud, L; Newman, JC; Phillips, M; Rosenquist, PB; Rumble, ME; Szabo, ST; Youssef, NA, 2019) |
| "The REST-IT study found the addition of zolpidem-controlled release (CR) provided a significant reduction in observer-rated measurement of suicidal ideation (the Columbia Suicide Severity Rating Scale) in 103 depressed outpatients with insomnia and suicidal ideation, but without significant change in a self-report measure of suicidal ideation (the Scale for Suicide Ideation)." | 4.31 | The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned. ( Benca, RM; Dzurny, TN; Krystal, AD; Looney, SW; McCall, WV; McCloud, LL; Mercado, K; Rosenquist, PB, 2023) |
| "Zolpidem is a clinically effective hypnotic medication for treating chronic insomnia." | 4.02 | Impetuous suicidality with zolpidem use: a case report and minireview. ( Brady, M; Cunningham, MG, 2021) |
| " Dose-response analysis also revealed a significantly increased risk of suicide in patients receiving ≥ 180cDDD (cumulative defined daily doses) of zolpidem (124 times), followed by 90-179cDDD (113 times) and <90cDDD (93 times) of zolpidem compared to non-users." | 2.82 | Zolpidem use and risk of suicide: A systematic review and meta-analysis. ( Agarwal, NB; Ashif Khan, M; Garg, A; Hussain, S; Khan, H; Yadav, DK, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 5 (83.33) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, H | 1 |
| Garg, A | 1 |
| Agarwal, NB | 1 |
| Yadav, DK | 1 |
| Ashif Khan, M | 1 |
| Hussain, S | 1 |
| McCall, WV | 4 |
| Mercado, K | 1 |
| Dzurny, TN | 1 |
| McCloud, LL | 1 |
| Krystal, AD | 4 |
| Benca, RM | 4 |
| Rosenquist, PB | 3 |
| Looney, SW | 1 |
| Youssef, NA | 1 |
| McCloud, L | 1 |
| Newman, JC | 1 |
| Case, D | 1 |
| Rumble, ME | 3 |
| Szabo, ST | 1 |
| Phillips, M | 1 |
| Dickson, DA | 1 |
| Brady, M | 1 |
| Cunningham, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reducing Suicidal Ideation Through Insomnia Treatment[NCT01689909] | Phase 4 | 103 participants (Actual) | Interventional | 2012-12-06 | Completed | ||
| Addressing Nocturnal Sleep/Wake Effects on Risk of Suicide in Older Adults (ANSWERS-OA): A Pilot, Open-Label, Randomized Controlled Trial of Digital Cognitive Behavioral Therapy for Insomnia[NCT04986007] | 70 participants (Anticipated) | Interventional | 2021-09-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"This device measures arm motion over time, reported as average actigraphic activity Level. The scale is reported as a continuous measure ranging from 0-200, and reported as the average score for each hour for all 24-hours of the day. Higher score represent greater c=activity at that point in time" (NCT01689909)
Timeframe: 8 weeks of treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Scale for Suicide Ideation Score Greater Than or Equal to 6 | 150 |
| Scale for Suicide Ideation Score Less Than 6 | 170 |
This is one of the subscales of the Basis 32. It is self-administered. This subscale has 7 items, each scored 0-4. The totals score is an average of the scores of these 7 items. Higher scores indicate more difficulty with daily living and role functioning. (NCT01689909)
Timeframe: 8 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Zolpidem-CR | 1.51 |
| Placebo | 1.60 |
The Beck Hopelessness Scale is self administered and has 20 'true/false' choices. Some items are reversed scored. The range of scores for the total is 0-20, with higher scores indicating greater hopelessness (NCT01689909)
Timeframe: 8 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Zolpidem-CR | 9.40 |
| Placebo | 9.63 |
"The suicide ideation scale of the C-SSRS is rated 0-5, with 0 meaning no suicidal ideation, 1 meaning a wish t be dead, 2 meaning non-specific active suicidal thoughts, 3 meaning active suicidal ideation with any methods but no plan or intent, 4 meaning active suicidal ideation with some intent but no specific plan, and 5 meaning active suicidal ideation with intent and a specific plan" (NCT01689909)
Timeframe: 8 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Zolpidem-CR | 0.5447 |
| Placebo | 0.8067 |
This self-rated scale has 5 items, with asymmetric weighting of each item. The range of the total score is 0-37, with higher scores indicating worse nightmares (NCT01689909)
Timeframe: 8 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Zolpidem-CR | 5.74 |
| Placebo | 6.44 |
The Dysfunctional Beliefs and Attitudes About Sleep scale has 16 items and is self administered. Each item is scored 0-10. The total score is an average of the scores of the 16 items. Hence the range of the total score is also 0-10, with higher scores indicating greater dysfunctional beliefs about sleep (NCT01689909)
Timeframe: 8 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Zolpidem-CR | 6.03 |
| Placebo | 6.07 |
This version of the Hamilton Rating Scale for Depression uses 24 items, with a possible total score ranging from 0-74, with higher scores indicating worse depression (NCT01689909)
Timeframe: 8 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Zolpidem-CR | 14.93 |
| Placebo | 15.89 |
The Insomnia Severity Index is self rated. It has 7 items, each scored 0-4. Therefore the range of scores is 0-28, with higher scores indicating worse insomnia (NCT01689909)
Timeframe: 8 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Zolpidem-CR | 11.28 |
| Placebo | 13.72 |
This is the total score for the Scale for Suicide Ideation. It has 19 items, each scored 0-2, for a maximum of 38 points. Higher scores indicate worse suicidal ideation (NCT01689909)
Timeframe: Over 8 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Zolpidem-CR | 4.66 |
| Placebo | 5.25 |
1 review available for zolpidem and Suicidal Ideation
| Article | Year |
|---|---|
Zolpidem use and risk of suicide: A systematic review and meta-analysis.
Topics: Humans; Risk Assessment; Sleep Initiation and Maintenance Disorders; Suicidal Ideation; Suicide, Att | 2022 |
3 trials available for zolpidem and Suicidal Ideation
| Article | Year |
|---|---|
Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.
Topics: Adolescent; Adult; Aged; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination | 2019 |
Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.
Topics: Adolescent; Adult; Aged; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination | 2019 |
Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.
Topics: Adolescent; Adult; Aged; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination | 2019 |
Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.
Topics: Adolescent; Adult; Aged; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination | 2019 |
An exploratory analysis of the association of circadian rhythm dysregulation and insomnia with suicidal ideation over the course of treatment in individuals with depression, insomnia, and suicidal ideation.
Topics: Circadian Rhythm; Depression; Humans; Sleep Initiation and Maintenance Disorders; Suicidal Ideation; | 2020 |
Blinding and bias in a hypnotic clinical trial.
Topics: Adolescent; Adult; Bias; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Hypnotics | 2021 |
2 other studies available for zolpidem and Suicidal Ideation
| Article | Year |
|---|---|
The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned.
Topics: Depression; Humans; Outpatients; Psychiatric Status Rating Scales; Sleep Initiation and Maintenance | 2023 |
Impetuous suicidality with zolpidem use: a case report and minireview.
Topics: Female; Humans; Hypnotics and Sedatives; Sleep Initiation and Maintenance Disorders; Suicidal Ideati | 2021 |