zolpidem has been researched along with Sleep Apnea, Obstructive in 14 studies
Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-one patients with obstructive sleep apnea underwent polysomnography and sleep endoscopy during zolpidem-induced sleep and during DISE with propofol." | 5.56 | Comparison of upper airway obstruction during zolpidem-induced sleep and propofol-induced sleep in patients with obstructive sleep apnea: a pilot study. ( Cahali, MB; Genta, PR; Grad, GF; Lorenzi-Filho, G; Ordones, AB; Sennes, LU, 2020) |
| "Sodium oxybate (SXB) is approved for cataplexy and excessive daytime sleepiness in narcolepsy." | 5.15 | A 2-week, polysomnographic, safety study of sodium oxybate in obstructive sleep apnea syndrome. ( Feldman, N; George, CF; Grzeschik, SM; Inhaber, N; Lai, C; Steininger, TL; Zheng, Y, 2011) |
| "Sodium oxybate (SXB) is an approved drug for the treatment of excessive daytime sleepiness (EDS) and cataplexy in narcolepsy." | 5.14 | A safety trial of sodium oxybate in patients with obstructive sleep apnea: Acute effects on sleep-disordered breathing. ( Feldman, N; George, CF; Grzeschik, SM; Inhaber, N; Lai, C; Steininger, TL; Zheng, Y, 2010) |
| " Pitolisant, a novel histamine-3 receptor antagonist/inverse agonist, gained approval for the treatment of excessive daytime sleepiness in adults with narcolepsy as well as obstructive sleep apnea." | 5.05 | New pharmacologic agents for insomnia and hypersomnia. ( Earl, DC; Van Tyle, KM, 2020) |
| "16 patients with severe obstructive sleep apnea (apnea+ hypopnea index > 30/hr), on CPAP therapy for at least 6 months." | 2.72 | Effect of zolpidem on the efficacy of continuous positive airway pressure as treatment for obstructive sleep apnea. ( Berry, RB; Patel, PB, 2006) |
| "Pretreatment with zolpidem significantly improved polysomnographic quality and may decrease the need to repeat polysomnograms." | 2.71 | Does zolpidem enhance the yield of polysomnography? ( Andrada, T; Eliasson, AH; Khramtsov, A; Kristo, DA; Lettieri, CJ, 2005) |
| "Twenty-one patients with obstructive sleep apnea underwent polysomnography and sleep endoscopy during zolpidem-induced sleep and during DISE with propofol." | 1.56 | Comparison of upper airway obstruction during zolpidem-induced sleep and propofol-induced sleep in patients with obstructive sleep apnea: a pilot study. ( Cahali, MB; Genta, PR; Grad, GF; Lorenzi-Filho, G; Ordones, AB; Sennes, LU, 2020) |
| "A total of 26 confirmed obstructive sleep apnea patients were recruited in this one-year study." | 1.56 | Tongue imaging during drug-induced sleep ultrasound in obstructive sleep apnea patients. ( Abuan, MRA; Chen, NH; Fang, TJ; Hsin, LJ; Lee, LA; Li, HY; Lin, WN; Lo, YL, 2020) |
| "Zolpidem was well tolerated and significantly improved the sleep efficiency compared with the no-drug night (77 ± 12% versus 84 ± 9%, p = 0." | 1.51 | The effects of zolpidem in obstructive sleep apnea - An open-label pilot study. ( Carberry, JC; Eckert, DJ; Grunstein, RR, 2019) |
| "Consecutive patients with suspected obstructive sleep apnea (OSA) referred for polysomnography (PSG) had demographic and PSG data abstracted." | 1.46 | Eszopiclone and Zolpidem Do Not Affect the Prevalence of the Low Arousal Threshold Phenotype. ( Andrada, TF; Bridges, E; Costan-Toth, C; Forsthoefel, D; Holley, AB; Sheikh, KL; Smith, PR, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 4 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Ordones, AB | 1 |
| Grad, GF | 1 |
| Cahali, MB | 1 |
| Lorenzi-Filho, G | 1 |
| Sennes, LU | 1 |
| Genta, PR | 1 |
| Abuan, MRA | 1 |
| Lin, WN | 1 |
| Hsin, LJ | 1 |
| Lee, LA | 1 |
| Fang, TJ | 1 |
| Chen, NH | 1 |
| Lo, YL | 1 |
| Li, HY | 1 |
| Earl, DC | 1 |
| Van Tyle, KM | 1 |
| Messineo, L | 1 |
| Carter, SG | 1 |
| Taranto-Montemurro, L | 1 |
| Chiang, A | 1 |
| Vakulin, A | 1 |
| Adams, RJ | 1 |
| Carberry, JC | 3 |
| Eckert, DJ | 3 |
| Fisher, LP | 1 |
| Grunstein, RR | 2 |
| Gandevia, SC | 1 |
| McKenzie, DK | 1 |
| Butler, JE | 1 |
| Smith, PR | 1 |
| Sheikh, KL | 1 |
| Costan-Toth, C | 1 |
| Forsthoefel, D | 1 |
| Bridges, E | 1 |
| Andrada, TF | 1 |
| Holley, AB | 1 |
| George, CF | 2 |
| Feldman, N | 2 |
| Inhaber, N | 2 |
| Steininger, TL | 2 |
| Grzeschik, SM | 2 |
| Lai, C | 2 |
| Zheng, Y | 2 |
| Dopp, JM | 1 |
| Morgan, BJ | 1 |
| Berry, RB | 1 |
| Patel, PB | 1 |
| Bradshaw, DA | 1 |
| Ruff, GA | 1 |
| Murphy, DP | 1 |
| Pelayo, R | 1 |
| Guilleminault, C | 1 |
| Lettieri, CJ | 1 |
| Eliasson, AH | 1 |
| Andrada, T | 1 |
| Khramtsov, A | 1 |
| Kristo, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy Among Obstructive Sleep Apnea Subjects Referred for Surgical Treatment[NCT03004014] | 28 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Prospective, Randomized, Placebo Controlled Trial Assessing the Effects of Ezopiclone on the Quality of Overnight Polysomnography and CPAP Titration[NCT00507117] | Phase 4 | 300 participants (Anticipated) | Interventional | 2007-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for zolpidem and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
New pharmacologic agents for insomnia and hypersomnia.
Topics: Azepines; Carbamates; Dementia; Disorders of Excessive Somnolence; GABA-A Receptor Agonists; Humans; | 2020 |
Pharmacologic approaches for the management of symptoms and cardiovascular consequences of obstructive sleep apnea in adults.
Topics: Benzhydryl Compounds; Cardiovascular Diseases; Central Nervous System Stimulants; Combined Modality | 2010 |
7 trials available for zolpidem and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Addition of zolpidem to combination therapy with atomoxetine-oxybutynin increases sleep efficiency and the respiratory arousal threshold in obstructive sleep apnoea: A randomized trial.
Topics: Arousal; Atomoxetine Hydrochloride; Humans; Mandelic Acids; Sleep; Sleep Apnea, Obstructive; Zolpide | 2021 |
Role of common hypnotics on the phenotypic causes of obstructive sleep apnoea: paradoxical effects of zolpidem.
Topics: Adult; Arousal; Azabicyclo Compounds; Continuous Positive Airway Pressure; Cross-Over Studies; Doubl | 2017 |
A safety trial of sodium oxybate in patients with obstructive sleep apnea: Acute effects on sleep-disordered breathing.
Topics: Adjuvants, Anesthesia; Adult; Aged; Benzhydryl Compounds; Central Nervous System Stimulants; Comorbi | 2010 |
A 2-week, polysomnographic, safety study of sodium oxybate in obstructive sleep apnea syndrome.
Topics: Adjuvants, Anesthesia; Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Combined Moda | 2011 |
Effect of zolpidem on the efficacy of continuous positive airway pressure as treatment for obstructive sleep apnea.
Topics: Adult; Arousal; Body Mass Index; Combined Modality Therapy; Continuous Positive Airway Pressure; Cro | 2006 |
An oral hypnotic medication does not improve continuous positive airway pressure compliance in men with obstructive sleep apnea.
Topics: Administration, Oral; Adult; Continuous Positive Airway Pressure; Humans; Hypnotics and Sedatives; M | 2006 |
Does zolpidem enhance the yield of polysomnography?
Topics: Adult; Continuous Positive Airway Pressure; Demography; Female; Humans; Laboratories; Male; Middle A | 2005 |
5 other studies available for zolpidem and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Comparison of upper airway obstruction during zolpidem-induced sleep and propofol-induced sleep in patients with obstructive sleep apnea: a pilot study.
Topics: Airway Obstruction; Endoscopy; Humans; Pilot Projects; Propofol; Sleep; Sleep Apnea, Obstructive; Zo | 2020 |
Tongue imaging during drug-induced sleep ultrasound in obstructive sleep apnea patients.
Topics: Adult; Body Mass Index; Female; Humans; Male; Middle Aged; Mouth; Polysomnography; Regression Analys | 2020 |
The effects of zolpidem in obstructive sleep apnea - An open-label pilot study.
Topics: Female; Humans; Male; Middle Aged; Pilot Projects; Sleep Aids, Pharmaceutical; Sleep Apnea, Obstruct | 2019 |
Eszopiclone and Zolpidem Do Not Affect the Prevalence of the Low Arousal Threshold Phenotype.
Topics: Adult; Arousal; Eszopiclone; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Phenotype; | 2017 |
The role of hypnotics in continuous positive airway pressure compliance.
Topics: Continuous Positive Airway Pressure; Humans; Hypnotics and Sedatives; Patient Compliance; Pyridines; | 2007 |