zolpidem has been researched along with Minimally Conscious State in 22 studies
Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Case reports of the use of zolpidem in Permanent Vegetative States (PVS) have led to interest by the media and court judgements defining treatment with such drugs." | 5.35 | Zolpidem in a minimally conscious state. ( Dawson, K; Lewis, S; McDonald, C; Pentland, B; Pringle, AM; Singh, R; Smith, S, 2008) |
| "Zolpidem is a unique nonbenzodiazepine sedative hypnotic drug that selectively binds to omega-1 gamma-aminobutyric acid receptors in the brain." | 5.35 | Transient reversal of anoxic brain injury-related minimally conscious state after zolpidem administration: a case report. ( Ring, H; Shames, JL, 2008) |
| "Zolpidem is an effective medicine to restore brain function in patients in vegetative state after brain injury, especially for those whose brain injuries are mainly in non-brain-stem areas." | 5.19 | Zolpidem arouses patients in vegetative state after brain injury: quantitative evaluation and indications. ( Cai, K; Chen, D; Du, B; Shan, A; Zhang, Y; Zhong, X, 2014) |
| " Zolpidem is a nonbenzodiazepine hypnotic used to treat insomnia that has also been observed to paradoxically improve arousal in those with DOC, such as the vegetative or minimally conscious states." | 4.95 | Improved Arousal and Motor Function Using Zolpidem in a Patient With Space-Occupying Intracranial Lesions: A Case Report. ( Bomalaski, MN; Smith, SR, 2017) |
| "Sutton and Clauss presented a detailed review about the effectiveness of zolpidem, discussing recoveries from brain damage due to strokes, trauma and hypoxia." | 3.88 | Zolpidem efficacy and safety in disorders of consciousness. ( Estévez, M; Machado, C; Rodriguez-Rojas, R, 2018) |
| "The study investigates the effect of zolpidem (CAS 82626-48-0) on brain injuries and cerebellar diaschisis." | 3.72 | Effect of zolpidem on brain injury and diaschisis as detected by 99mTc HMPAO brain SPECT in humans. ( Clauss, RP; Nel, WH, 2004) |
| "To study the Zolpidem arousing effect in persistent vegetative state (PVS) patients combining clinical evaluation, autonomic assessment by heart rate variability (HRV), and EEG records." | 2.79 | Zolpidem arousing effect in persistent vegetative state patients: autonomic, EEG and behavioral assessment. ( Carballo, M; Carrick, FR; Chinchilla, M; DeFina, P; Estévez, M; Gutiérrez, J; Leisman, G; Machado, A; Machado, C; Melillo, R; Olivares, A; Pérez-Cruz, N; Pérez-Nellar, J; Rodríguez, R; Schiavi, A, 2014) |
| "Zolpidem was associated with a tendency towards reduced responsiveness in patients with persistent vegetative states." | 2.75 | Zolpidem for persistent vegetative state--a placebo-controlled trial in pediatrics. ( Egan, JR; Gill, D; Gillis, J; Howman-Giles, R; London, K; Scheinberg, A; Snyman, N, 2010) |
| " In drug responders, repeated dosing appears to maintain consciousness." | 2.74 | Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial. ( Myers, R; Whyte, J, 2009) |
| "Zolpidem has been used with mixed effects in patients presenting with Prolonged Disorders of Consciousness (PDOC)." | 1.51 | An analysis of the effects of using Zolpidem and an innovative multimodal interdisciplinary team approach in prolonged disorders of consciousness (PDOC). ( Cronin, H; Delargy, M; Galligan, I; Gray, D; McCann, A; O'Connor, R; O'Toole, C, 2019) |
| "Zolpidem is a non-benzodiazepine drug used for the therapy of insomnia, which has selectivity for stimulating the effect of GABA-A receptors." | 1.39 | Zolpidem induces paradoxical metabolic and vascular changes in a patient with PVS. ( Alvarez, L; Carballo, M; Carrick, FR; Chinchilla, M; DeFina, P; Estevez, M; Machado, C; Pavon, N; Perez-Nellar, J; Rodriguez-Rojas, R, 2013) |
| "We also consider "vegetative state" a pejorative term that should be replaced." | 1.38 | A Cuban perspective on management of persistent vegetative state. ( Beltrán, C; Carballo, M; Estévez, M; Fleitas, M; Gutiérrez, J; Machado, C; Olivares, A; Pando, A; Pérez-Nellar, J; Rodríguez, R, 2012) |
| "Case reports of the use of zolpidem in Permanent Vegetative States (PVS) have led to interest by the media and court judgements defining treatment with such drugs." | 1.35 | Zolpidem in a minimally conscious state. ( Dawson, K; Lewis, S; McDonald, C; Pentland, B; Pringle, AM; Singh, R; Smith, S, 2008) |
| "Zolpidem is a unique nonbenzodiazepine sedative hypnotic drug that selectively binds to omega-1 gamma-aminobutyric acid receptors in the brain." | 1.35 | Transient reversal of anoxic brain injury-related minimally conscious state after zolpidem administration: a case report. ( Ring, H; Shames, JL, 2008) |
| "Zolpidem is an omega 1 specific indirect GABA agonist that is used for insomnia, but may have efficacy in brain damage." | 1.33 | Drug induced arousal from the permanent vegetative state. ( Clauss, R; Nel, W, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, Q | 1 |
| Hao, J | 1 |
| Kang, X | 1 |
| Yuan, F | 1 |
| Liu, Y | 1 |
| Chen, R | 1 |
| Liu, X | 1 |
| Li, R | 1 |
| Jiang, W | 1 |
| Spiegel, DR | 1 |
| Ahuja, K | 1 |
| Reid, FE | 1 |
| Hegde, S | 1 |
| Carbaugh, E | 1 |
| Tran, V | 1 |
| Forte, S | 1 |
| Strauss, E | 1 |
| Lagbo, J | 1 |
| Lau, J | 1 |
| Fins, JJ | 1 |
| Machado, C | 5 |
| Estévez, M | 5 |
| Rodriguez-Rojas, R | 2 |
| Delargy, M | 1 |
| O'Connor, R | 1 |
| McCann, A | 1 |
| Galligan, I | 1 |
| Cronin, H | 1 |
| Gray, D | 1 |
| O'Toole, C | 1 |
| Du, B | 1 |
| Shan, A | 1 |
| Zhang, Y | 1 |
| Zhong, X | 1 |
| Chen, D | 1 |
| Cai, K | 1 |
| Alvarez, L | 1 |
| Carballo, M | 4 |
| Perez-Nellar, J | 4 |
| Pavon, N | 1 |
| Chinchilla, M | 3 |
| Carrick, FR | 2 |
| DeFina, P | 2 |
| Rodríguez, R | 3 |
| Leisman, G | 1 |
| Melillo, R | 1 |
| Schiavi, A | 1 |
| Gutiérrez, J | 3 |
| Machado, A | 2 |
| Olivares, A | 2 |
| Pérez-Cruz, N | 1 |
| Calabrò, RS | 1 |
| Aricò, I | 1 |
| De Salvo, S | 1 |
| Conti-Nibali, V | 1 |
| Bramanti, P | 1 |
| Bomalaski, MN | 1 |
| Smith, SR | 1 |
| Whyte, J | 1 |
| Myers, R | 1 |
| Clauss, RP | 2 |
| Georgiopoulos, M | 1 |
| Katsakiori, P | 1 |
| Kefalopoulou, Z | 1 |
| Ellul, J | 1 |
| Chroni, E | 1 |
| Constantoyannis, C | 1 |
| Snyman, N | 1 |
| Egan, JR | 1 |
| London, K | 1 |
| Howman-Giles, R | 1 |
| Gill, D | 1 |
| Gillis, J | 1 |
| Scheinberg, A | 1 |
| Portela, L | 1 |
| García-Roca, MC | 1 |
| Beltrán, C | 2 |
| Fleitas, M | 1 |
| Pando, A | 1 |
| Nel, WH | 1 |
| Clauss, R | 1 |
| Nel, W | 1 |
| Dyer, C | 1 |
| Cohen, SI | 1 |
| Duong, TT | 1 |
| Singh, R | 1 |
| McDonald, C | 1 |
| Dawson, K | 1 |
| Lewis, S | 1 |
| Pringle, AM | 1 |
| Smith, S | 1 |
| Pentland, B | 1 |
| Shames, JL | 1 |
| Ring, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjuvant Acupuncture Therapy in Patients With Severe Head Injury: a Randomized Controlled Trial[NCT01773291] | 24 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Eye response (E)~There are four grades starting with the most severe:~No eye opening~Eye opening in response to pain stimulus.~Eye opening to speech.~Eyes opening spontaneously Verbal response (V)~There are five grades starting with the most severe:~No verbal response~Incomprehensible sounds.~Inappropriate words.~Confused.~Oriented. Motor response (M)~There are six grades:~No motor response~Decerebrate posturing accentuated by pain~Decorticate posturing accentuated by pain~Withdrawal from pain~Localizes to pain~Obeys commands~The sum of the score was measured (3 - 15) before and after treatment during hospitalization. The higher score, the better outcome." (NCT01773291)
Timeframe: 6 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Acupuncture | 3.14 |
| Laser Acupuncture | 3.11 |
| Control Group | 4.67 |
"Medical Research Council (MRC) muscle-grading scale Grade MRC grade of muscle strength 0 No movement~Flicker of movement only~Movement possible when assisted by gravity or gravity is eliminated~Movement possible against gravity but without imposed resistance~Weak movement possible against gravity~Normal movement against gravity and against imposed resistance~The 4 muscle groups were assessed on the 0 to 5 scale and scores were summed before and after treatment during hospitalization. The total score ranges from 0-20, with higher score indicating better outcome." (NCT01773291)
Timeframe: 6 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Acupuncture | 4.29 |
| Laser Acupuncture | 4.33 |
| Control Group | 2.83 |
3 reviews available for zolpidem and Minimally Conscious State
| Article | Year |
|---|---|
Improved Arousal and Motor Function Using Zolpidem in a Patient With Space-Occupying Intracranial Lesions: A Case Report.
Topics: Arousal; Brain Neoplasms; Consciousness Disorders; Follow-Up Studies; GABA-A Receptor Agonists; Huma | 2017 |
Vegetative state and minimally conscious state: a review of the therapeutic interventions.
Topics: Baclofen; Consciousness; Electric Stimulation Therapy; Humans; Persistent Vegetative State; Pyridine | 2010 |
Increased arousal in a patient with anoxic brain injury after administration of zolpidem.
Topics: Adult; Arousal; GABA Agonists; Humans; Hypoxia, Brain; Male; Persistent Vegetative State; Pyridines; | 2008 |
4 trials available for zolpidem and Minimally Conscious State
| Article | Year |
|---|---|
Zolpidem arouses patients in vegetative state after brain injury: quantitative evaluation and indications.
Topics: Adult; Brain; Brain Injuries; Cerebrovascular Circulation; Cysteine; Female; Humans; Hypnotics and S | 2014 |
Zolpidem arousing effect in persistent vegetative state patients: autonomic, EEG and behavioral assessment.
Topics: Adolescent; Adult; Autonomic Nervous System; Double-Blind Method; Electroencephalography; Female; He | 2014 |
Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial.
Topics: Adult; Brain Injuries; Double-Blind Method; Female; GABA Agonists; Glasgow Coma Scale; Humans; Male; | 2009 |
Zolpidem for persistent vegetative state--a placebo-controlled trial in pediatrics.
Topics: Adolescent; Brain; Cerebrovascular Circulation; Child; Child, Preschool; Double-Blind Method; GABA-A | 2010 |
15 other studies available for zolpidem and Minimally Conscious State
| Article | Year |
|---|---|
EEG dynamics induced by zolpidem forecast consciousness evolution in prolonged disorders of consciousness.
Topics: Consciousness; Consciousness Disorders; Electroencephalography; Humans; Persistent Vegetative State; | 2023 |
A Case of Ovarian Teratoma-Induced N-Methyl-D-Aspartate Receptor Antibody Encephalitis Presenting With Psychosis and Catatonia, Progressing to the Minimally Conscious State and Successfully Treated With Adjunctive Zolpidem.
Topics: Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Autoantibodies; Catatonia; Encephalitis; Female; Hu | 2023 |
Mosaic Decisionmaking and Reemergent Agency after Severe Brain Injury.
Topics: Brain Injuries; Communication; Decision Making; Ethics, Medical; Humans; Hypnotics and Sedatives; Ma | 2018 |
Zolpidem efficacy and safety in disorders of consciousness.
Topics: Brain; Consciousness; Humans; Hypoxia; Persistent Vegetative State; Stroke; Zolpidem | 2018 |
An analysis of the effects of using Zolpidem and an innovative multimodal interdisciplinary team approach in prolonged disorders of consciousness (PDOC).
Topics: Adult; Awareness; Chronic Disease; Consciousness Disorders; Female; Humans; Hypnotics and Sedatives; | 2019 |
Zolpidem induces paradoxical metabolic and vascular changes in a patient with PVS.
Topics: Adult; Female; GABA-A Receptor Agonists; Hemodynamics; Humans; Magnetic Resonance Imaging; Magnetic | 2013 |
Transient awakening from vegetative state: is high-dose zolpidem more effective?
Topics: Female; GABA-A Receptor Agonists; Heart Arrest; Humans; Middle Aged; Persistent Vegetative State; Py | 2015 |
Neurotransmitters in coma, vegetative and minimally conscious states, pharmacological interventions.
Topics: Antidepressive Agents, Tricyclic; Baclofen; Coma; Dopamine Agents; GABA Agonists; gamma-Aminobutyric | 2010 |
Autonomic, EEG, and behavioral arousal signs in a PVS case after Zolpidem intake.
Topics: Arousal; Autonomic Nervous System; Blood Pressure; Brain Waves; Electroencephalography; Female; Hear | 2011 |
A Cuban perspective on management of persistent vegetative state.
Topics: Brain; Brain Stem; Cuba; Electroencephalography; Humans; Hypnotics and Sedatives; Magnetic Resonance | 2012 |
Effect of zolpidem on brain injury and diaschisis as detected by 99mTc HMPAO brain SPECT in humans.
Topics: Adult; Brain Injuries; Cerebellar Diseases; Cerebrovascular Circulation; Child, Preschool; Diabetes | 2004 |
Drug induced arousal from the permanent vegetative state.
Topics: Adult; Arousal; Drug Administration Schedule; Follow-Up Studies; GABA Agonists; Glasgow Coma Scale; | 2006 |
Husband says judge's ruling on wife's treatment was "inhumane".
Topics: Female; Humans; Hypnotics and Sedatives; Persistent Vegetative State; Pyridines; Right to Die; Unite | 2007 |
Zolpidem in a minimally conscious state.
Topics: Adult; Brain Injuries; Drug Evaluation; Humans; Male; Neurotransmitter Agents; Observer Variation; P | 2008 |
Transient reversal of anoxic brain injury-related minimally conscious state after zolpidem administration: a case report.
Topics: Female; Humans; Hypnotics and Sedatives; Hypoxia; Middle Aged; Persistent Vegetative State; Pyridine | 2008 |