Page last updated: 2024-11-05

zolpidem and Down Syndrome

zolpidem has been researched along with Down Syndrome in 1 studies

Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.

Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Research Excerpts

ExcerptRelevanceReference
"Flumazenil has been reported to reverse the CNS effects of zolpidem."1.39Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil. ( Carstairs, SD; Negus, E; Thornton, SL, 2013)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thornton, SL1
Negus, E1
Carstairs, SD1

Other Studies

1 other study available for zolpidem and Down Syndrome

ArticleYear
Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil.
    Pediatric emergency care, 2013, Volume: 29, Issue:11

    Topics: Antidotes; Central Nervous System Depressants; Child; Coma; Down Syndrome; Drug Overdose; Emergencie

2013