Page last updated: 2024-11-05

zolpidem and Dementia

zolpidem has been researched along with Dementia in 8 studies

Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research Excerpts

ExcerptRelevanceReference
"We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD)."7.81An increased risk of reversible dementia may occur after zolpidem derivative use in the elderly population: a population-based case-control study. ( Chang, CM; Chi, CH; Hsu, HC; Kao, CH; Lin, CC; Shih, HI; Tu, YF, 2015)
" Pitolisant, a novel histamine-3 receptor antagonist/inverse agonist, gained approval for the treatment of excessive daytime sleepiness in adults with narcolepsy as well as obstructive sleep apnea."5.05New pharmacologic agents for insomnia and hypersomnia. ( Earl, DC; Van Tyle, KM, 2020)
"Sleep disturbance is common in dementia and often treated with Z-drugs (zopiclone, zaleplon, and zolpidem)."3.96Adverse effects of Z-drugs for sleep disturbance in people living with dementia: a population-based cohort study. ( Aldus, C; Arthur, A; Ballard, C; Boyd, PJ; Fox, C; Howard, R; Loke, YK; Maidment, I; Richardson, K; Savva, GM; Steel, N, 2020)
"We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD)."3.81An increased risk of reversible dementia may occur after zolpidem derivative use in the elderly population: a population-based case-control study. ( Chang, CM; Chi, CH; Hsu, HC; Kao, CH; Lin, CC; Shih, HI; Tu, YF, 2015)
"Zolpidem was well tolerated with no withdrawal symptoms during the second 7-day placebo treatment period."2.67A double-blind, comparative study of zolpidem and placebo in the treatment of insomnia in elderly psychiatric in-patients. ( Coquelin, JP; Curson, H; Shaw, SH, 1992)
"The prevalence of insomnia increases with age and affects up to 35% of community-dwelling adults with dementia."2.45Non-pharmacologic treatment of insomnia in persons with dementia. ( Darvishi, R; Kunik, ME; Shub, D, 2009)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's1 (12.50)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Yoon, K1
Kim, JT1
Kwack, WG1
Kim, D1
Lee, KT1
Yang, S1
Lee, S1
Choi, YJ1
Chung, EK1
Earl, DC1
Van Tyle, KM1
Richardson, K1
Loke, YK1
Fox, C1
Maidment, I1
Howard, R1
Steel, N1
Arthur, A1
Boyd, PJ1
Aldus, C1
Ballard, C1
Savva, GM1
Shih, HI1
Lin, CC1
Tu, YF1
Chang, CM1
Hsu, HC1
Chi, CH1
Kao, CH1
Shub, D1
Darvishi, R1
Kunik, ME1
Jarry, C1
Fontenas, JP1
Jonville-Béra, AP1
Autret-Leca, E1
Cotroneo, A1
Gareri, P1
Nicoletti, N1
Lacava, R1
Grassone, D1
Maina, E1
De Sarro, G1
Cabodi, S1
Shaw, SH1
Curson, H1
Coquelin, JP1

Reviews

2 reviews available for zolpidem and Dementia

ArticleYear
New pharmacologic agents for insomnia and hypersomnia.
    Current opinion in pulmonary medicine, 2020, Volume: 26, Issue:6

    Topics: Azepines; Carbamates; Dementia; Disorders of Excessive Somnolence; GABA-A Receptor Agonists; Humans;

2020
Non-pharmacologic treatment of insomnia in persons with dementia.
    Geriatrics, 2009, Volume: 64, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antidepressive Agents, Tricyclic; Circadian Rhyth

2009

Trials

1 trial available for zolpidem and Dementia

ArticleYear
A double-blind, comparative study of zolpidem and placebo in the treatment of insomnia in elderly psychiatric in-patients.
    The Journal of international medical research, 1992, Volume: 20, Issue:2

    Topics: Aged; Dementia; Depression; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; H

1992

Other Studies

5 other studies available for zolpidem and Dementia

ArticleYear
Potentially Inappropriate Medication Use in Patients with Dementia.
    International journal of environmental research and public health, 2022, 09-10, Volume: 19, Issue:18

    Topics: Aged; Benzodiazepines; Cholinergic Antagonists; Dementia; Female; Histamine; Humans; Inappropriate P

2022
Adverse effects of Z-drugs for sleep disturbance in people living with dementia: a population-based cohort study.
    BMC medicine, 2020, 11-24, Volume: 18, Issue:1

    Topics: Acetamides; Aged, 80 and over; Azabicyclo Compounds; Cohort Studies; Dementia; Female; Humans; Male;

2020
An increased risk of reversible dementia may occur after zolpidem derivative use in the elderly population: a population-based case-control study.
    Medicine, 2015, Volume: 94, Issue:17

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Comorbidity; Dementia; Dose-Respon

2015
Beneficial effect of zolpidem for dementia.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:11

    Topics: Dementia; Female; Humans; Hypnotics and Sedatives; Middle Aged; Pyridines; Zolpidem

2002
Effectiveness and safety of hypnotic drugs in the treatment of insomnia in over 70-year old people.
    Archives of gerontology and geriatrics, 2007, Volume: 44 Suppl 1

    Topics: Aged; Cognition Disorders; Dementia; Depression; Drug Administration Schedule; Female; Health Status

2007