zolpidem has been researched along with Brain Injuries in 14 studies
Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During 15 years, 23 clinical reports and 6 studies have demonstrated associations between sub-sedative doses of zolpidem and recoveries from brain damage due to strokes, trauma and hypoxia." | 8.95 | A review of the evidence of zolpidem efficacy in neurological disability after brain damage due to stroke, trauma and hypoxia: A justification of further clinical trials. ( Clauss, RP; Sutton, JA, 2017) |
| "Case reports of the use of zolpidem in Permanent Vegetative States (PVS) have led to interest by the media and court judgements defining treatment with such drugs." | 5.35 | Zolpidem in a minimally conscious state. ( Dawson, K; Lewis, S; McDonald, C; Pentland, B; Pringle, AM; Singh, R; Smith, S, 2008) |
| "Zolpidem is an effective medicine to restore brain function in patients in vegetative state after brain injury, especially for those whose brain injuries are mainly in non-brain-stem areas." | 5.19 | Zolpidem arouses patients in vegetative state after brain injury: quantitative evaluation and indications. ( Cai, K; Chen, D; Du, B; Shan, A; Zhang, Y; Zhong, X, 2014) |
| "During 15 years, 23 clinical reports and 6 studies have demonstrated associations between sub-sedative doses of zolpidem and recoveries from brain damage due to strokes, trauma and hypoxia." | 4.95 | A review of the evidence of zolpidem efficacy in neurological disability after brain damage due to stroke, trauma and hypoxia: A justification of further clinical trials. ( Clauss, RP; Sutton, JA, 2017) |
| "The study investigates the effect of zolpidem (CAS 82626-48-0) on brain injuries and cerebellar diaschisis." | 3.72 | Effect of zolpidem on brain injury and diaschisis as detected by 99mTc HMPAO brain SPECT in humans. ( Clauss, RP; Nel, WH, 2004) |
| "Amantadine has been shown to promote the rate of neurologic recovery for patients with traumatic disorders of consciousness when administered between 4 and 16 weeks, as demonstrated by a well-designed randomized control trial." | 3.54 | Pharmacology in Treatment of Patients with Disorders of Consciousness. ( Marino, MH, 2024) |
| " In drug responders, repeated dosing appears to maintain consciousness." | 2.74 | Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial. ( Myers, R; Whyte, J, 2009) |
| "Six zolpidem doses were administered in total, and repeat magnetic resonance imaging on postoperative day 16 showed markedly improved regional edema." | 1.62 | Postoperative Treatment of Intracranial Hypotension Venous Congestion-Associated Brain Injury With Zolpidem. ( Desmarais, LM; Milleville, KA; Wagner, AK, 2021) |
| "Case reports of the use of zolpidem in Permanent Vegetative States (PVS) have led to interest by the media and court judgements defining treatment with such drugs." | 1.35 | Zolpidem in a minimally conscious state. ( Dawson, K; Lewis, S; McDonald, C; Pentland, B; Pringle, AM; Singh, R; Smith, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Marino, MH | 1 |
| Desmarais, LM | 1 |
| Milleville, KA | 1 |
| Wagner, AK | 1 |
| Sutton, JA | 1 |
| Clauss, RP | 4 |
| Fins, JJ | 1 |
| Du, B | 1 |
| Shan, A | 1 |
| Zhang, Y | 1 |
| Zhong, X | 1 |
| Chen, D | 1 |
| Cai, K | 1 |
| Williams, ST | 1 |
| Conte, MM | 1 |
| Goldfine, AM | 1 |
| Noirhomme, Q | 1 |
| Gosseries, O | 1 |
| Thonnard, M | 1 |
| Beattie, B | 1 |
| Hersh, J | 1 |
| Katz, DI | 1 |
| Victor, JD | 1 |
| Laureys, S | 1 |
| Schiff, ND | 1 |
| Akeju, O | 1 |
| Brown, EN | 1 |
| Whyte, J | 1 |
| Myers, R | 1 |
| Alisky, JM | 1 |
| Nyakale, NE | 2 |
| Nel, W | 1 |
| Sathekge, M | 1 |
| Belozertsev, IuA | 1 |
| Shchelkanova, OA | 1 |
| Belozertsev, FIu | 1 |
| Iuntsev, SV | 1 |
| Nel, HW | 1 |
| Sathekge, MM | 1 |
| Nel, WH | 1 |
| Singh, R | 1 |
| McDonald, C | 1 |
| Dawson, K | 1 |
| Lewis, S | 1 |
| Pringle, AM | 1 |
| Smith, S | 1 |
| Pentland, B | 1 |
2 reviews available for zolpidem and Brain Injuries
| Article | Year |
|---|---|
Pharmacology in Treatment of Patients with Disorders of Consciousness.
Topics: Amantadine; Brain Injuries; Consciousness; Consciousness Disorders; Humans; Randomized Controlled Tr | 2024 |
A review of the evidence of zolpidem efficacy in neurological disability after brain damage due to stroke, trauma and hypoxia: A justification of further clinical trials.
Topics: Brain Injuries; Humans; Hypnotics and Sedatives; Hypoxia; Nervous System Diseases; Pyridines; Stroke | 2017 |
2 trials available for zolpidem and Brain Injuries
| Article | Year |
|---|---|
Zolpidem arouses patients in vegetative state after brain injury: quantitative evaluation and indications.
Topics: Adult; Brain; Brain Injuries; Cerebrovascular Circulation; Cysteine; Female; Humans; Hypnotics and S | 2014 |
Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial.
Topics: Adult; Brain Injuries; Double-Blind Method; Female; GABA Agonists; Glasgow Coma Scale; Humans; Male; | 2009 |
10 other studies available for zolpidem and Brain Injuries
| Article | Year |
|---|---|
Postoperative Treatment of Intracranial Hypotension Venous Congestion-Associated Brain Injury With Zolpidem.
Topics: Aged; Brain Injuries; GABA-A Receptor Agonists; Humans; Hyperemia; Intracranial Hypotension; Male; P | 2021 |
Mosaic Decisionmaking and Reemergent Agency after Severe Brain Injury.
Topics: Brain Injuries; Communication; Decision Making; Ethics, Medical; Humans; Hypnotics and Sedatives; Ma | 2018 |
Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury.
Topics: Brain Injuries; Electroencephalography; Humans; Hypnotics and Sedatives; Pyridines; Zolpidem | 2013 |
Awakened by a sleeping pill.
Topics: Brain Injuries; Humans; Hypnotics and Sedatives; Pyridines; Zolpidem | 2013 |
Minimally-responsive head injury survivors may have chronic catatonia reversed years after an accident.
Topics: Accidents; Benzodiazepines; Brain Injuries; Craniocerebral Trauma; Electroconvulsive Therapy; Fructo | 2009 |
Clinical and brain SPECT scan response to zolpidem in patients after brain damage.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Brain; Brain Diseases; Brain Injuries; Female; | 2010 |
[Comparative evaluation of the hypnotic drugs under conditions of brain injury].
Topics: Animals; Azabicyclo Compounds; Brain Injuries; Hypnotics and Sedatives; Hypoxia; Injections, Intrape | 2012 |
Blood-brain barrier integrity in a zolpidem-responder patient.
Topics: Adult; Blood-Brain Barrier; Brain Injuries; GABA-A Receptor Agonists; Humans; Male; Pyridines; Tomog | 2012 |
Effect of zolpidem on brain injury and diaschisis as detected by 99mTc HMPAO brain SPECT in humans.
Topics: Adult; Brain Injuries; Cerebellar Diseases; Cerebrovascular Circulation; Child, Preschool; Diabetes | 2004 |
Zolpidem in a minimally conscious state.
Topics: Adult; Brain Injuries; Drug Evaluation; Humans; Male; Neurotransmitter Agents; Observer Variation; P | 2008 |