Page last updated: 2024-11-05

zolpidem and Ataxia

zolpidem has been researched along with Ataxia in 8 studies

Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.

Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"Zolpidem and triazolam produced dose-dependent reductions in locomotion and environment-directed behavior and increased ataxia and procumbent posture."3.71Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys. ( Cook, J; Ma, C; Platt, DM; Rowlett, JK; Spealman, RD, 2002)
"Diazepam (2 mg/kg) induced significant ataxia and muscle relaxation, which were completely prevented by pretreatment with flumazenil (10 mg/kg) and βCCt (20 mg/kg)."1.38The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats. ( Cook, JM; Divljaković, J; Milić, M; Rallapalli, S; Savić, MM; Timić, T; van Linn, ML, 2012)
"Zolpidem (Stilnox) is a non-benzodiazepine hypnotic drug of the imidazopyridine class intended for treatment of insomnia in humans."1.36Zolpidem poisoning in a cat. ( Czopowicz, M; Frymus, T; Szalus-Jordanow, O, 2010)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Forrester, MB1
Czopowicz, M1
Szalus-Jordanow, O1
Frymus, T1
Milić, M1
Divljaković, J1
Rallapalli, S1
van Linn, ML1
Timić, T1
Cook, JM1
Savić, MM1
Platt, DM1
Rowlett, JK1
Spealman, RD1
Cook, J1
Ma, C1
Trapani, G3
Lopedota, A1
Boghetich, G1
Latrofa, A3
Franco, M3
Sanna, E3
Liso, G3
Kohut, SJ1
Ator, NA1
Pantaleo, MR2
Provenzano, MR1
Maciocco, E1
Massa, F1
Tuveri, F1

Other Studies

8 other studies available for zolpidem and Ataxia

ArticleYear
Pattern of pediatric zolpidem ingestions reported to Texas poison control centers, 2000 to 2006.
    Pediatric emergency care, 2009, Volume: 25, Issue:1

    Topics: Accidents, Home; Ataxia; Child, Preschool; Dose-Response Relationship, Drug; Female; First Aid; Guid

2009
Zolpidem poisoning in a cat.
    Australian veterinary journal, 2010, Volume: 88, Issue:8

    Topics: Animals; Antidotes; Ataxia; Cat Diseases; Cats; Flumazenil; Hyperkinesis; Hypnotics and Sedatives; M

2010
The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats.
    Behavioural pharmacology, 2012, Volume: 23, Issue:2

    Topics: Animals; Ataxia; Benzodiazepines; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; GABA-A Recept

2012
Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys.
    Psychopharmacology, 2002, Volume: 164, Issue:2

    Topics: Animals; Ataxia; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Drug Interactions; F

2002
Encapsulation and release of the hypnotic agent zolpidem from biodegradable polymer microparticles containing hydroxypropyl-beta-cyclodextrin.
    International journal of pharmaceutics, 2003, Dec-11, Volume: 268, Issue:1-2

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Ataxia; beta-Cyclodextrins; Chemistry, Pharmaceutical; C

2003
Novel discriminative stimulus effects of TPA023B, subtype-selective gamma-aminobutyric-acid(A)/benzodiazepine modulator: comparisons with zolpidem, lorazepam, and TPA023.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:1

    Topics: Animals; Ataxia; Conditioning, Operant; Data Interpretation, Statistical; Discrimination, Psychologi

2008
Physicochemical characterization and in vivo properties of Zolpidem in solid dispersions with polyethylene glycol 4000 and 6000.
    International journal of pharmaceutics, 1999, Jul-05, Volume: 184, Issue:1

    Topics: Animals; Ataxia; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Hypnot

1999
Complexation of zolpidem with 2-hydroxypropyl-beta-, methyl-beta-, and 2-hydroxypropyl-gamma-cyclodextrin: effect on aqueous solubility, dissolution rate, and ataxic activity in rat.
    Journal of pharmaceutical sciences, 2000, Volume: 89, Issue:11

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Ataxia; beta-Cyclodextrins; Cyclodextrins; gamma-Cyclode

2000