zolpidem has been researched along with Apnea, Sleep in 7 studies
Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with zolpidem significantly improved polysomnographic quality and may decrease the need to repeat polysomnograms." | 2.71 | Does zolpidem enhance the yield of polysomnography? ( Andrada, T; Eliasson, AH; Khramtsov, A; Kristo, DA; Lettieri, CJ, 2005) |
| "Patients with dementias, such as Alzheimer's disease (AD), often have nocturnally disrupted sleep." | 2.42 | Sleep disorders in Alzheimer's disease and other dementias. ( Bliwise, DL, 2004) |
| "Research on insomnia has provided a number of important new insights, but fundamental deficits in our understanding remain." | 2.41 | Future directions in the management of insomnia. ( Richardson, GS; Roth, T, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmad, B | 1 |
| Sankari, A | 1 |
| Eshraghi, M | 1 |
| Aldwaikat, A | 1 |
| Yarandi, H | 1 |
| Zeineddine, S | 1 |
| Salloum, A | 1 |
| Badr, MS | 1 |
| Beaumont, M | 1 |
| Batéjat, D | 1 |
| Coste, O | 1 |
| Van Beers, P | 1 |
| Colas, A | 1 |
| Clère, JM | 1 |
| Piérard, C | 1 |
| Bliwise, DL | 1 |
| Lettieri, CJ | 1 |
| Eliasson, AH | 1 |
| Andrada, T | 1 |
| Khramtsov, A | 1 |
| Kristo, DA | 1 |
| Richardson, GS | 1 |
| Roth, T | 1 |
| Roblin, X | 1 |
| Boudemaghe, T | 1 |
| Paris, F | 1 |
| Pellissier, L | 1 |
| Le Gall, S | 1 |
| Cirignotta, F | 1 |
| Mondini, S | 1 |
| Zucconi, M | 1 |
| Gerardi, R | 1 |
| Farolfi, A | 1 |
| Lugaresi, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sleep and Breathing in Health and Disease (Part 2A - Chemical Stimuli, Sleep and Breathing in the General Population)[NCT04720547] | Phase 4 | 14 participants (Actual) | Interventional | 2018-07-03 | Completed | ||
| Treatment of High-altitude Sleep Disturbance: A Double-blind Comparison of Temazepam Versus Acetazolamide.[NCT01519544] | 34 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| Prospective, Randomized, Placebo Controlled Trial Assessing the Effects of Ezopiclone on the Quality of Overnight Polysomnography and CPAP Titration[NCT00507117] | Phase 4 | 300 participants (Anticipated) | Interventional | 2007-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
CO2 reserve is the requisite change to induce central apnea is referred to as the CO2 reserve, which can be positive or negative. CO2 reserve is defined as the difference between the eupneic end-tidal CO2 pressure and the end-tidal CO2 pressure induced by the ventilation protocol that is sufficient to trigger a central apnea as defined by the American Academy of Sleep Medicine. (NCT04720547)
Timeframe: one night
| Intervention | mmHg (Mean) |
|---|---|
| Zolpidem | -0.63 |
| No Treatment | -0.44 |
Controller gain is a ventilatory response to changes in end-tidal PCO2. Controller gain was calculated by dividing the difference in minute ventilation between the post-mechanical ventilation induced by the ventilation protocol and steady-state respiration by the difference in the end-tidal CO2 pressure between the mechanical ventilation and steady-state respiration. (NCT04720547)
Timeframe: one night
| Intervention | L/min*mmHg (Mean) |
|---|---|
| Zolpidem | 2.39 |
| No Treatment | 3.95 |
A measure of the frequency of respiratory-related arousals during sleep (NCT04720547)
Timeframe: one night
| Intervention | events per hour (Mean) |
|---|---|
| Zolpidem | 23.3 |
| No Treatment | 39.7 |
The nadir pressure in the upper airway (supra-glottic pressure) prior to the occurrence of an arousal (NCT04720547)
Timeframe: one night
| Intervention | cmH2O (Mean) |
|---|---|
| Zolpidem | -8.72 |
| No Treatment | -8.25 |
"Plant gain is a blood gas response to a change in ventilation. This measure represents the effectiveness of the plant in eliminating CO2. Steady-state plant gain was calculated from the ratio of end-tidal CO2 to minute ventilation during stable respiration." (NCT04720547)
Timeframe: one night
| Intervention | mmHg*L/min (Mean) |
|---|---|
| Zolpidem | 4.78 |
| No Treatment | 5.27 |
The number of central apneas and hypopneas per hour of sleep was obtained from polysomnography studies. (NCT04720547)
Timeframe: one night
| Intervention | events per hour (Mean) |
|---|---|
| Zolpidem | 14.1 |
| No Treatment | 29.9 |
2 reviews available for zolpidem and Apnea, Sleep
| Article | Year |
|---|---|
Sleep disorders in Alzheimer's disease and other dementias.
Topics: Accidental Falls; Alzheimer Disease; Antipsychotic Agents; Body Temperature Regulation; Chronobiolog | 2004 |
Future directions in the management of insomnia.
Topics: Comorbidity; Corticotropin-Releasing Hormone; Depressive Disorder; GABA-A Receptor Agonists; Humans; | 2001 |
4 trials available for zolpidem and Apnea, Sleep
| Article | Year |
|---|---|
Effect of Zolpidem on nocturnal arousals and susceptibility to central sleep apnea.
Topics: Arousal; Carbon Dioxide; Cross-Over Studies; Humans; Sleep Apnea Syndromes; Sleep Apnea, Central; Zo | 2023 |
Effects of zolpidem and zaleplon on sleep, respiratory patterns and performance at a simulated altitude of 4,000 m.
Topics: Acetamides; Adult; Altitude Sickness; Atmosphere Exposure Chambers; Attention; Cognition; Cross-Over | 2004 |
Does zolpidem enhance the yield of polysomnography?
Topics: Adult; Continuous Positive Airway Pressure; Demography; Female; Humans; Laboratories; Male; Middle A | 2005 |
Zolpidem-polysomnographic study of the effect of a new hypnotic drug in sleep apnea syndrome.
Topics: Humans; Hypnotics and Sedatives; Pyridines; Sleep Apnea Syndromes; Zolpidem | 1988 |
1 other study available for zolpidem and Apnea, Sleep
| Article | Year |
|---|---|
[Unexplained increase in aminotransferases and obstructive sleep apnea syndrome].
Topics: Female; Humans; Hypnotics and Sedatives; Liver; Middle Aged; Pyridines; Sleep Apnea Syndromes; Trans | 2002 |