zolpidem has been researched along with Apnea, Central in 4 studies
Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmad, B | 1 |
| Sankari, A | 1 |
| Eshraghi, M | 1 |
| Aldwaikat, A | 1 |
| Yarandi, H | 1 |
| Zeineddine, S | 1 |
| Salloum, A | 1 |
| Badr, MS | 1 |
| Grimaldi, D | 1 |
| Provini, F | 1 |
| Vetrugno, R | 1 |
| Antelmi, E | 1 |
| Donadio, V | 1 |
| Liguori, R | 1 |
| Pierangeli, G | 1 |
| Cortelli, P | 1 |
| Montagna, P | 1 |
| Quadri, S | 1 |
| Drake, C | 1 |
| Hudgel, DW | 1 |
| Rahangdale, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sleep and Breathing in Health and Disease (Part 2A - Chemical Stimuli, Sleep and Breathing in the General Population)[NCT04720547] | Phase 4 | 14 participants (Actual) | Interventional | 2018-07-03 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
CO2 reserve is the requisite change to induce central apnea is referred to as the CO2 reserve, which can be positive or negative. CO2 reserve is defined as the difference between the eupneic end-tidal CO2 pressure and the end-tidal CO2 pressure induced by the ventilation protocol that is sufficient to trigger a central apnea as defined by the American Academy of Sleep Medicine. (NCT04720547)
Timeframe: one night
| Intervention | mmHg (Mean) |
|---|---|
| Zolpidem | -0.63 |
| No Treatment | -0.44 |
Controller gain is a ventilatory response to changes in end-tidal PCO2. Controller gain was calculated by dividing the difference in minute ventilation between the post-mechanical ventilation induced by the ventilation protocol and steady-state respiration by the difference in the end-tidal CO2 pressure between the mechanical ventilation and steady-state respiration. (NCT04720547)
Timeframe: one night
| Intervention | L/min*mmHg (Mean) |
|---|---|
| Zolpidem | 2.39 |
| No Treatment | 3.95 |
A measure of the frequency of respiratory-related arousals during sleep (NCT04720547)
Timeframe: one night
| Intervention | events per hour (Mean) |
|---|---|
| Zolpidem | 23.3 |
| No Treatment | 39.7 |
The nadir pressure in the upper airway (supra-glottic pressure) prior to the occurrence of an arousal (NCT04720547)
Timeframe: one night
| Intervention | cmH2O (Mean) |
|---|---|
| Zolpidem | -8.72 |
| No Treatment | -8.25 |
"Plant gain is a blood gas response to a change in ventilation. This measure represents the effectiveness of the plant in eliminating CO2. Steady-state plant gain was calculated from the ratio of end-tidal CO2 to minute ventilation during stable respiration." (NCT04720547)
Timeframe: one night
| Intervention | mmHg*L/min (Mean) |
|---|---|
| Zolpidem | 4.78 |
| No Treatment | 5.27 |
The number of central apneas and hypopneas per hour of sleep was obtained from polysomnography studies. (NCT04720547)
Timeframe: one night
| Intervention | events per hour (Mean) |
|---|---|
| Zolpidem | 14.1 |
| No Treatment | 29.9 |
2 trials available for zolpidem and Apnea, Central
| Article | Year |
|---|---|
Effect of Zolpidem on nocturnal arousals and susceptibility to central sleep apnea.
Topics: Arousal; Carbon Dioxide; Cross-Over Studies; Humans; Sleep Apnea Syndromes; Sleep Apnea, Central; Zo | 2023 |
Improvement of idiopathic central sleep apnea with zolpidem.
Topics: Adult; Aged; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Polysomnography; Prospectiv | 2009 |
2 other studies available for zolpidem and Apnea, Central
| Article | Year |
|---|---|
Idiopathic central sleep apnoea syndrome treated with zolpidem.
Topics: Follow-Up Studies; Humans; Hypnotics and Sedatives; Male; Middle Aged; Polysomnography; Pyridines; S | 2008 |
Effective treatment for idiopathic central sleep apnea?
Topics: Humans; Hypnotics and Sedatives; Pyridines; Research Design; Sleep Apnea, Central; Zolpidem | 2009 |