zolpidem has been researched along with Alzheimer Disease in 10 studies
Zolpidem: An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
zolpidem : An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD)." | 7.81 | An increased risk of reversible dementia may occur after zolpidem derivative use in the elderly population: a population-based case-control study. ( Chang, CM; Chi, CH; Hsu, HC; Kao, CH; Lin, CC; Shih, HI; Tu, YF, 2015) |
| "We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD)." | 3.81 | An increased risk of reversible dementia may occur after zolpidem derivative use in the elderly population: a population-based case-control study. ( Chang, CM; Chi, CH; Hsu, HC; Kao, CH; Lin, CC; Shih, HI; Tu, YF, 2015) |
| "The prevalence of insomnia increases with age and affects up to 35% of community-dwelling adults with dementia." | 2.45 | Non-pharmacologic treatment of insomnia in persons with dementia. ( Darvishi, R; Kunik, ME; Shub, D, 2009) |
| "Patients with dementias, such as Alzheimer's disease (AD), often have nocturnally disrupted sleep." | 2.42 | Sleep disorders in Alzheimer's disease and other dementias. ( Bliwise, DL, 2004) |
| "Zolpidem users were identified as patients who used zolpidem during the enrollment period." | 1.46 | The Association Between the Use of Zolpidem and the Risk of Alzheimer's Disease Among Older People. ( Cheng, HT; Erickson, SR; Hong, JL; Lin, FJ; Wu, CH, 2017) |
| " The dosage was titrated in 5-mg increments until the optimum dosage was reached for case 1 (15 mg hs) and case 2 (10 mg hs)." | 1.30 | Zolpidem for dementia-related insomnia and nighttime wandering. ( Hocking, LB; Shelton, PS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Louzada, LL | 1 |
| Machado, FV | 1 |
| Quintas, JL | 1 |
| Ribeiro, GA | 1 |
| Silva, MV | 1 |
| Mendonça-Silva, DL | 1 |
| Gonçalves, BSB | 1 |
| Nóbrega, OT | 1 |
| Camargos, EF | 1 |
| Kobayashi, R | 1 |
| Morioka, D | 1 |
| Suzuki, A | 1 |
| Kawakatsu, S | 1 |
| Otani, K | 1 |
| Cheng, HT | 1 |
| Lin, FJ | 1 |
| Erickson, SR | 1 |
| Hong, JL | 1 |
| Wu, CH | 1 |
| Burke, SL | 1 |
| Hu, T | 1 |
| Spadola, CE | 1 |
| Burgess, A | 1 |
| Li, T | 1 |
| Cadet, T | 1 |
| Shih, HI | 1 |
| Lin, CC | 1 |
| Tu, YF | 1 |
| Chang, CM | 1 |
| Hsu, HC | 1 |
| Chi, CH | 1 |
| Kao, CH | 1 |
| Yin, Y | 1 |
| Liu, Y | 1 |
| Zhuang, J | 1 |
| Pan, X | 1 |
| Li, P | 1 |
| Yang, Y | 1 |
| Li, YP | 1 |
| Zhao, ZQ | 1 |
| Huang, LQ | 1 |
| Zhao, ZX | 1 |
| Shub, D | 1 |
| Darvishi, R | 1 |
| Kunik, ME | 1 |
| Bliwise, DL | 1 |
| Jackson, CW | 1 |
| Pitner, JK | 1 |
| Mintzer, JE | 1 |
| Shelton, PS | 1 |
| Hocking, LB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Z-Drugs for the Treatment of Sleep Disorders in Alzheimer's Disease: a Randomized, Triple-blind, Placebo-controlled Study[NCT03075241] | Phase 3 | 62 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for zolpidem and Alzheimer Disease
| Article | Year |
|---|---|
Non-pharmacologic treatment of insomnia in persons with dementia.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antidepressive Agents, Tricyclic; Circadian Rhyth | 2009 |
Sleep disorders in Alzheimer's disease and other dementias.
Topics: Accidental Falls; Alzheimer Disease; Antipsychotic Agents; Body Temperature Regulation; Chronobiolog | 2004 |
2 trials available for zolpidem and Alzheimer Disease
| Article | Year |
|---|---|
The efficacy and safety of zolpidem and zopiclone to treat insomnia in Alzheimer's disease: a randomized, triple-blind, placebo-controlled trial.
Topics: Aged, 80 and over; Alzheimer Disease; Azabicyclo Compounds; Double-Blind Method; Humans; Hypnotics a | 2022 |
Low-Dose Atypical Antipsychotic Risperidone Improves the 5-Year Outcome in Alzheimer's Disease Patients with Sleep Disturbances.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Caregivers; Donepezil; Female; Hum | 2015 |
6 other studies available for zolpidem and Alzheimer Disease
| Article | Year |
|---|---|
Low-dose zolpidem-induced visual hallucinations in prodromal dementia with Lewy bodies.
Topics: Alzheimer Disease; Hallucinations; Humans; Lewy Body Disease; Prodromal Symptoms; Zolpidem | 2021 |
The Association Between the Use of Zolpidem and the Risk of Alzheimer's Disease Among Older People.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Female; Humans; Hypnot | 2017 |
Treatment of Sleep Disturbance May Reduce the Risk of Future Probable Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Correlation of Data; Female; Humans; Male; Proportional | 2019 |
An increased risk of reversible dementia may occur after zolpidem derivative use in the elderly population: a population-based case-control study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Comorbidity; Dementia; Dose-Respon | 2015 |
Zolpidem for the treatment of agitation in elderly demented patients.
Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Confusion; Female; Humans; Hypnotics and Sed | 1996 |
Zolpidem for dementia-related insomnia and nighttime wandering.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Humans; Hypnotics and Sedatives; Male; Pyridines | 1997 |